Roman Sankowski

In imaging-based spatial transcriptomics (Xenium CosMx), 40% RNAs are Not assigned to segmented cells

This amazing preprint @fabiantheis.bsky.social studies the origin, heterogeneity & biological inference (Modeling cell protrusion/contacts😎) of unassigned RNAs

www.biorxiv.org/content/10.6...

Beautiful new color palette #dataScience

Love this analysis

A promotional graphic for an EMBO Workshop titled "Brain (epi)genome," scheduled for 21-24 April 2026 at EMBL Heidelberg and virtually. The background features colorful illustrations of brain cells and synapses. Logos for EMBO and EMBL are displayed at the bottom.

How does the (epi)genome generate the brain’s huge diversity of cell types? This @‌events.embl.org workshop brings together leaders in genomics, neuroscience, and epigenetics to explore the mechanisms shaping neural identity, connectivity, memory, and disease.

🔗 plos.io/4aJ9IS2

#EMBOBrainEpi

That's right. Worse than Pointless
www.nytimes.com/2026/02/23/o...

A son of sharecroppers, a Freedom Rider, a moral force in Congress, John Lewis taught us that democracy is not a state, it is an act. When we see injustice, we do not look away. We get in good trouble. And we build bridges despite adversity. Happy Heavenly Birthday, Congressman.

Modeling the evolutionary dynamics of clonal hematopoiesis @natgenet.nature.com @moffittnews.bsky.social
www.nature.com/articles/s41...

Base barrier cells provide compartmentalization of choroid plexus, brain and CSF - Nature Neuroscience Verhaege et al. identify a conserved fibroblast barrier population at the base of the choroid plexus that compartmentalizes brain–CSF interfaces and is disrupted by inflammation, revealing a new site ...

Base barrier cells provide compartmentalization of choroid plexus, brain and CSF | Nature Neuroscience

www.nature.com/articles/s41...

Selecting the optimal cell migration assay: fundamentals and practical guidelines www.nature.com/articles/s4...

Ulcerative colitis induces stem- and effector-like γδ T cell subsets influencing therapeutic response @sciimmunology.bsky.social
www.science.org/doi/10.1126/...

Childhood brain tumors instruct cranial hematopoiesis and immunotolerance @natgenet.nature.com
@gilbertsonlab.bsky.social @cruk-ci.bsky.social
www.nature.com/articles/s41...

Classic lying with charts. #propaganda

chatomics! new blog post: Understanding prcomp() center and scale Arguments for Single-Cell RNA-seq PCA divingintogeneticsandgenomics.com/post/unders...

PolyAseqTrap: a universal tool for genome-wide identification and quantification of polyadenylation sites from different 3′ end sequencing data link.springer.com/article/10....

github github.com/APAexplorer...

Quest for Orthologs in the era of Data Deluge and AI: Challenges and Innovations in Orthology Prediction and Data Integration - Journal of Molecular Evolution The rapid advancement of DNA sequencing technologies and computational algorithms has led to an unprecedented surge in genomic data, driven by several large-scale sequencing projects worldwide. Orthol...

Quest for Orthologs in the era of Data Deluge and AI: Challenges and Innovations in Orthology Prediction and Data Integration

link.springer.com/article/10.1...

1/12 What is “CHIP” in blood sequencing, and why does it mess up mutation calls?

Not every mutation is created equal.

Quick explainer for oncologists, cardiologists, and genomics folks 👇

A pan-cancer single-cell transcriptomic atlas of human bone metastases This study constructs a pan-cancer single-cell atlas of human bone metastases, revealing niche-specific stromal and immune programs that drive tumor proliferation and immunotherapy resistance. Combine...

Important insights into the tumor #microenvironment of spinal bone #metastases.

A pan-cancer single-cell transcriptomic atlas of human bone metastases: Cell Reports Medicine

www.cell.com/cell-reports...

Scientists successfully achieve 'permanent disappearance of pancreatic cancer' in new study for cure The team searching for a pancreatic cancer cure included the ‘renowned Dr Mariano Barbacid,' a legend in the cancer research field

The world feels like its on fire, but things like this is why im thankful to be born in this day and age with science advancing like it has been. These are heroes

www.unilad.com/news/health/...

Don was taken into custody by federal agents last night in Los Angeles.

The arrest of Don Lemon is textbook fascism—a brazen attempt to silence reporting on a criminal regime. Stand up for Don, because our rights stand and fall with those of courageous journalists throughout this country.

Meningeal B cells: Emerging players at the brain border Meningeal B cells are increasingly recognized as active players at the brain border. Chen and Xu review recent advances in understanding their heterogeneity, developmental origins, spatial organizatio...

Meningeal B cells: Emerging players at the brain border: Immunity

www.cell.com/immunity/abs...

4 Machine Learning Books You Can Read for FREE (Legally)

www.clcoding.com/2026/01/4-ma...

Vous en avez marre des GAFAM et de l’ultra dépendance aux services US ? Voici des solutions, toutes présentes dans notre fiction en accès libre « GAFAM : 24h dans la peau d’un repenti ».

Si vous avez des suggestions, n’hésitez pas à en donner en commentaires 🙏🏼

Ageing promotes microglial accumulation of slow-degrading synaptic proteins - Nature Newly developed mouse models that enable cell-specific analyses of proteostasis dynamics across the lifespan of the mice reveal key aspects of neuronal proteostasis with ageing.

Does the neuronal ‘aggregome’ explain neurodegeneration? A ne study from the Wyss-Coray lab suggest so using a novel methodology

Ageing promotes microglial accumulation of slow-degrading synaptic proteins | Nature

www.nature.com/articles/s41...

Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins - Nature Neuroscience The choroid plexus is a vital brain ventricular organ that produces cerebrospinal fluid. This study shows how developmental origins and local niches shape the specialization of choroid plexus macropha...

Important new findings on #choroid #plexus #macrophages - good Job Simone Brioschi and Marco Colonna!

Diversity and immune dynamics of choroid plexus macrophages are shaped by distinct developmental origins | Nature Neuroscience

www.nature.com/articles/s41...

There is currently not much free r secondary progressive MS, unfortunately. But we’re working on it from different angles 🤞🏻🤞🏻🤞🏻

Thank you for your reply Shannon! It’s impressive how nature works. Sorry to hear that the disease relapsed though

A GDF-15–GFRAL axis controls autoimmune T cell responses during neuroinflammation - Nature Immunology Here the authors show that endogenous or therapeutically delivered GDF-15 activates brainstem neurons that trigger splenic β-adrenergic signaling. This, in turn, suppresses autoreactive T cells and re...

Coo study showing how pregnancy reduces #MS relapses by 80%. Mechanisms: Specialized brainstem neurons detect the fetal signal GDF-15 and specifically dampen inflammatory cells through the sympathetic nervous system—preventing their entry into the CNS.

www.nature.com/articles/s41...