Transient inhibition of type I interferon enhances CD8βΊ T cell stemness and #vaccine protection. From Benjamin Broomfield @benjbroom.bsky.social, Joanna Groom @groomlab.bsky.social and colleagues π rupress.org/jem/article/...
π In 2025: The Year in Experimental Medicine rupress.org/jem/collecti...
@brigetteduckworth.bsky.social @benjbroom.bsky.social @raymondqin.bsky.social @taylahjbennett.bsky.social @chinweetan.bsky.social
Hey "Friends"
The 2025 edition of our #AwkwardLabPhoto celebrates an incredible year of growth, publications, promotions, PhD submissions and grads
I feel immensely proud and grateful to be part of this team
The 2025 ππ¦π΄π΅ π°π§ πππ highlights research in basic #immunology, #immunotherapy & #TumorImmunology, #InbornErrorsOfImmunity, #neurodegeneration, & #inflammation. We remain grounded in our commitment to publishing studies that push the boundaries of our knowledge forward π rupress.org/jem/collecti...
ππ₯ our @jem.org paper βTransient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protectionβ is in the 2025 Best of JEM collection
This work was led by @benjbroom.bsky.social @wehi-research.bsky.social
check out the original thread..
bsky.app/profile/groo...
Another fantastic @ASI annual meeting, with @benjbroom.bsky.social (New Investigator finalist) and @brigetteduckworth.bsky.social (Symposia session) sharing the latest work from our lab.
Loved catching up with old friends and hearing the current research from this brilliant network.
Thrilled to make the cover of @natimmunol.nature.com this month.
A version of this warhol-inspired image has been in my head almost since we first conceived this Tfh diversity project (many, many years ago) @wehi-research.bsky.social
π PhD positions available @MonashUni
Join our lab to explore how neurons and immune cells shape gut immunity!
𧬠Single-cell RNAseq
π¬ 3D imaging
π§ Neuro-immune interactions
π₯ Great mentoring & collaborations
Apply now π tinyurl.com/Seilletlab
Innate lymphoid cells 3 (ILC3s) are a subset of immune cells that are critical to gut immunity.β―When there is excess fat, such as after a rich meal, ILC3s store this fat in tiny lipid droplets to maintain their function. In this 3D illustration, we can see a lipid droplet (in orange) inside an ILC3.
A landmark WEHI-led study has uncovered how our daily food choices are having an immediate effect on our gut health.
Brilliant research led byDr Cyril Seillet and Dr Le Xiong, that could help pinpoint #chronicinflammation at the source. Now published in Immunity.
www.wehi.edu.au/news/fast-fo...
π¨ New publication alert! π¨
Thrilled to share our latest research out today in @jclinical-invest.bsky.social! This work is another great outcome of my amazing clinical research partnership with first author Samantha Chan and RMH. @wehi-research.bsky.social #immunology #research #JCI
Excited to have our latest research published in @jem.org this week and also highlighted by @natrevimmunol.nature.com
@wehi-research.bsky.social @benjbroom.bsky.social
A visualisation of immune cells, with headline "Long-lasting vaccines of the future a step closer"
Future vaccines a step closer. Research from @groomlab.bsky.social, @benjbroom.bsky.social and team use novel approach and mRNA tech to boost stem cell-like memory CD8+ T cells after vaccination.
Published in @jem.org
www.wehi.edu.au/news/vaccine...
Our May issue is here! rupress.org/jem/issue/22...
Cleary et al. (doi.org/10.1084/jem....) developed a new intravital technique for imaging pulmonary lymphatics. The cover depicts a 3D projection of a whole lung lobe with lymphatics (purple) and smooth muscle (white) labeled.
@benjbroom.bsky.social et al. @groomlab.bsky.social show that transient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protection. rupress.org/jem/article/...
π In JEM #Immunology Collection: rupress.org/jem/collecti...
#AAI2025
This year's JEM #Immunology collection highlights recent findings in the field of B cells, CD8+ T cell stemness, priming and differentiation, CD4+ T cell heterogeneity, autoimmunity, lymphatic immunophysiology and innate immune signaling. π rupress.org/jem/collecti...
#AAI2025
Thrilled to share our work now published on @cp-immunity.bsky.social . Big thanks to our collaborators. Here we show that short-term High-Fat diet impairs ILC3 functions in producing IL-22 through microbiota-dependent and-independent mechanisms.
Youβre invited! Celebrate the Day of Immunology at WEHI on 29 April.
πΉHear from top scientists
πΉDiscover the new Snow Centre for Immune Health
πΉGo behind the scenes with a lab tour
πΉEnjoy morning tea & meet the team
Register now - www.immunology.org.au/events/-ASI-...
Happy one week of my @jem.org paper!
Our work from the @groomlab.bsky.social at @wehi-research.bsky.social identifies using early IFN-I blockade alongside mRNA vaccination to direct CD8+ T cell positioning in the lymph node to drive Tscm cell differentiation and enhance vaccine protection
Check it out it you havenβt already - online and open access π
rupress.org/jem/article/...
#WeekendRead! #InterferonFriendOrFoe!
@benjbroom.bsky.social @groomlab.bsky.social &co show @jem.org that transient type I IFN inhibition upon LCMV infection or a mRNA vaccine boosts stem-like memory CD8 T cells by altering their location within the draining lymph node, potentiating virus protection
Very excited our work out in @jem.org βTransient inhibition of type I interferon enhances CD8+ T cell stemness and vaccine protectionβ
@wehi-research.bsky.social led by talented (and determined) PhD student @benjbroom.bsky.social
Thread below.
@benjbroom.bsky.social et al. @groomlab.bsky.social show that early type I interferon blockade alters CXCR3 chemokine regulation & cell location to promote an antigen-dependent CD8+ T cell transition of precursor of exhausted T cells to stem cellβlike memory CD8+ T cells rupress.org/jem/article/...
So lucky to be in a lab that does great science AND indulges in a weird photoshoot π«Ά
Happy holidays!
