Jeremy Wilkinson

Accurate plasmid reconstruction from metagenomics data using assembly–alignment graphs and contrastive learning - Nature Biotechnology PlasMAAG uses cross-sample information to improve plasmid reconstruction from metagenomic samples.

Accurate plasmid reconstruction from metagenomics data using assembly–alignment graphs and contrastive learning www.nature.com/articles/s41... #jcampubs

New Preprint 📢 from our team 🔎 Critical assessment of #intratumor and #low #biomass #microbiome using #longread sequencing

Some studies suggest bacteria 🦠 live inside tumors and influence cancer treatment. But there’s also been a major #debate: in these very​ low-microbe tissue samples, how much 1/

🎬✨Now streaming: BEYOND THE BENCH

This season features:
• Santosha Vardhana on immune cell exhaustion and RNA splicing
• Andor Kiss on bringing HiFi into teaching
• Birgitt Schüele on repeat expansions across populations

Press play → bit.ly/4oLrOXu

#BeyondTheBench #PacBio #TheresHiFiForThat

I’m now at the wastewater symposium! Come say hi if you’re here and talk about high accuracy #longread sequencing for #microbial, #microbiome, and #metagenomics. @pacbio.bsky.social

Introducing CiFi from #PacBio and UC Davis!

It combines 3C with HiFi long reads to generate chromosome-scale, haplotype-resolved assemblies from a single SMRT Cell. Minimal samples, fewer runs, and maximum insight into complex genomes. Discover CiFi with us at #PAG33.

Details: bit.ly/4qLpVvb

Countdown starts now.
The genomics series we’ve all been waiting for – a #PacBio original series.

Trailer’s out.
Premiere’s coming.

Add it to your watchlist 👇
🔗 bit.ly/4oLrOXu

Just 5 spots left! Apply for your chance to attend a 2026 genomics conference with flights, hotel, and registration covered. Meet HiFi sequencing experts and take your research further.

Apply now: bit.ly/4oJQxvy

#PacBio #TheresHiFiForThat #HiFisequencing #Conferences

#Antimicrobial resistance is a global threat but understanding it starts with complete data. #PacBio HiFi reveals more complete plasmids, resistance genes, & mobile elements with high accuracy. Let’s sequence smarter to fight antimicrobial resistance.

🔗 bit.ly/4rgthrd

#AMR

If you’re at #AMPath2025 in Boston stop by the @pacbio.bsky.social booth #843 and say hi. #longread #HiFi

The 2026 #PacBio Genomics Conference Giveaway is LIVE!

Travel, registration, and hotel on us.

Here’s why showing up matters, straight from Amino Chain’s Jelani Clarke.

👉 Apply here: bit.ly/4oJQxvy

#TheresHiFiForThat #PacBio #Conferences

I’ll be at AMP. If you’ll be there, let me know and maybe we can catch up.

We’re at another @zymoresearch.bsky.social Biofestival at Harvard University. Come say hi if you’re here.

@pacbio.bsky.social

👀 ICYMI: During ASHG, we unveiled the next era of SMRT Cells and our new SPRQ-Nx chemistry on Revio, enabling comprehensive genomes for under $300 at scale. Beta access is now open, and spots are limited.

Read our press release for more details: bit.ly/4o06eyH

#ASHG25 #PacBio #SPRQNx #Revio

Our #ASHG25 PacBio Industry Workshop begins in one hour at 12:00pm in Room 153ABC, Level 1!  
 
Join speakers from Genome Institute of Singapore and Johns Hopkins University to celebrate 25 years of genomics, HiFi sequencing advances, and collaborative discoveries. 

#PacBio #ASHG #HiFisequencing

We’re at the @zymoresearch.bsky.social biofestival at the University of Maryland. Come say hi if you’re here.

@pacbio.bsky.social

Poster with an image of a PacBio Vega instrument, and the text: Molecular Analysis; New Technology; PacBio Vega Long Read Sequencing; Genome Assembly: Novel strains CpG methylation Metagenomics: Species and strain resolution Transcriptomics: de novo assembly Differential splicing

We are very excited to offer PacBio Long Read Sequencing in @molecularanalysis.bsky.social !
If you are interested, please get in touch: www.gla.ac.uk/colleges/mvl...
You can also save the date - 14 Nov - as we will be hosting reps from PacBio. More details to follow!

Alice: fast and haplotype-aware assembly of high-fidelity reads based on MSR sketching We introduce Mapping-friendly Sequence Reduction (MSR) sketches, a sketching method for high-fidelity (HiFi) long reads, and Alice, an as-sembler that operates directly on these sketches. MSR produces...

Another #metagenome assembly algorithm for #PacBio HiFi data - introducing Alice!

I'll be very interested to see how this performs on some of our trickier datasets.

More broadly, I'm happy to see continual development of tools for long-read #metagenomics.

doi.org/10.1101/2025...

South Korea selects PacBio HiFi Technology for National Pangenome Project - Bytes Europe October 14, 2025 | Tuesday | News

South Korea selects PacBio HiFi Technology for National Pangenome Project

https://www.byteseu.com/1453735/

South Korea selects PacBio HiFi Technology for National Pangenome Project October 14, 2025 | Tuesday | News More than 1,000 Korean genomes to be sequenced for global reference standards …

PacBio: $300 Genome Via Chemistry Update 🧬🖥️

omicsomics.blogspot.com/2025/10/pacb...

#PacBio announces major upcoming advances for #Revio and #Vega designed to lower genome costs, expand multiomic capabilities, and support regulated research.

The SPRQ-Nx chemistry, now in beta access, delivers complete genomes for under $300 at scale.

View the press release: bit.ly/4o06eyH

Here are a few highlights:
We first identified a 1.58 Mbp plasmid in an infant gut metagenome thanks to @pacbio.bsky.social sequencing. The average bacterial genome size in these communities is usually less than 5 Mbp so this was curious to us. We then found similar elements in other infants.

Most plasmids described in E. coli are small compared to the megaplasmids we identified here! Check out the preprint if you want to learn about these mysterious large elements and their potential functions 🧬. I’m very grateful to have had the opportunity to work on this in @banfieldlab.bsky.social

DDW Fall 2025 - Drug Discovery World (DDW) The DDW Fall issue examines why there is a need for a universal pneumococcal vaccine, why China might be the next global biopharma powerhouse and looks at developments in microbiome research and the t...

In the latest issue of DDW Journal, I explore how long-read genomics is driving high-resolution microbiome profiling and why precision microbiomics is set to become the next foundational layer in the drug discovery toolkit. 🧬

Read the full article here. 👉 bit.ly/4mq1xwp

#microbiome #longreads

Join us tomorrow if you can. Link below to register.

Science award? (The Scientist’s Top Innovations 2025) ✅
Design award? (Fast Company’s Innovation by Design 2025) ✅

Sequencer that’s turning heads everywhere? Vega. 🔥

#Vega #PacBio #HiFiSequencing

Microbes may be small, but the discoveries they drive are huge! 🦠

This #InternationalMicroorganismDay, see how #PacBio HiFi sequencing is uncovering microbial mysteries, from mapping hidden HIV-1 reservoirs to revealing novel AMR pathways.

Details here: bit.ly/4mSgPeL

Long and Kelsey just won the 2025 Microbiome SMRT Grant for HiFi shotgun metagenomics!! They will collaborate to optimize PacBio-compatible protocols for gut metagenomics, specifically generating high quality long-read data from IBD patients. Congrats to both! 🎉 🎉 www.pacb.com/blog/2025-mi...

The 2025 Long-Read Low Pass SMRT Grant for plant + animal sciences is now open! 🌱🐾

Apply to win free PacBio HiFi sequencing for your conservation or agricultural research.

Submit your 100-word proposal today: bit.ly/3IgrReu

#PacBio #SMRTGrant #HiFisequencing

Our first PacBio Revio run with over 140Gb average HiFi yield! This was for a pool of 16 human WGS libraries across 8 SMRTcells, giving >20x coverage per sample. We're running these samples as part of the "Genome of Sweden" project 🧬🇸🇪

New #metagenome assembly comparison of PacBio, ONT, and Illumina in human gut #microbiomes.

- "HiFi generated more cMAGs than ONT at every depth with either assembly method"
- "HiFi cMAGs had significantly higher completeness and lower contamination than ONT"

doi.org/10.1016/j.ce...