@andrewplygawko
Postdoc in Kyra Campbell's lab at the University of Sheffield - EMT, polarity and midgut morphology. Board game fan (not that I ever win) and musician (to the annoyance of everyone around me) when I'm not at the microscope
Check out new work @plosbiology.org from Daniel St Johnston´s lab visualizing how secretory cargo is targeted to apical vs. basolateral domains in #epithelial cells in real time. Nice collaboration highlighting the power of #RUSH in #Drosophila!
YEN Conference Poster
🚨 Abstracts are due next week! 🚨
Submit your abstract to give a talk or poster at YEN 2025 by the 12th April!
Share this opportunity with dev bio and stem cell PhD students. The conference is FREE and full of great science.
We are looking forward to seeing you there!
Lab’s latest: (mouse) mums grow their guts during pregnancy and lactation: www.cell.com/cell/fulltex...
I am thrilled to announce our latest #SingleCell manuscript: www.biorxiv.org/content/10.1...
We show that overactivation of Hh #signaling induces an EMT-like hybrid state in #Drosophila follicle cells. However, when we simultaneously overactivate EGFR/RAS signaling the cells form a lethal #cancer!
Spatial transcriptomics in fly brain and body. Wonderful collaboration with @steinaerts.bsky.social led by @jasperjanssens.bsky.social @pierremangeol.bsky.social Nikolai Hecker & Gabriele Partel - look at mRNA patterns in muscles and brains spatialfly.aertslab.org
elifesciences.org/reviewed-pre...
An amazing system - trialed in our Facility @mvls-srf.bsky.social - with some stunning examples of what it can do, including from Ignacio (Nacho) Fernandez of the Sanz Lab, SMB @uofgmvls.bsky.social.
Excited to welcome all our Dev Bio friends (and maybe even some Cell Biologists)
to Sheffield for the Northern(ish) England Developmental Biology meeting 10th July. We have some great speakers from the places in England where you get called Duck or Love and plenty of slots for ECR talks.
The Northern England Developmental Biology @bsdb.bsky.social @biologists.bsky.social meeting takes place on July 10th in Sheffield. Register by May 31st - its gonna be cool 😎 (see the poster below for details)!
Development folks: the next Northern England Developmental Biology @bsdb.bsky.social @biologists.bsky.social meeting will take place on the 10th of July in Sheffield. Great speaker line-up, cheap registration fee and plenty of slots for ECR talks. Registration deadline=31/5, see poster for details
Improvements in LM (top) and EM (bottom) of our micro-sam model (finetuned) compared to the default SAM model.
After a long journey, Segment Anything for Microscopy is now published in Nature Methods! We significantly improve SAM for interactive and automatic segmentation in light and electron microscopy and build a user-friendly tool.
www.nature.com/articles/s41...
Planar polarity in the Drosophila pupal wing is oriented by tissue stress but the mechanisms remain unclear. This study uncovers a crucial role for cell flow gradients in promoting planar polarity protein turnover and aligning proximodistal polarity.
New! 15y after the classic Aigouy et al "Cell Flow Reorients the Axis of Planar Polarity in the Wing Epithelium..." from lab of much missed Suzanne Eaton, we provide our take from post-doc Sara Tan "Tissue shear as a cue for aligning planar polarity in the developing Drosophila wing".
rdcu.be/d81Vn
Registration and abstract submission for YEN 2025 is officially open!
We are looking forward to seeing you at the 17th Young Embryologist Network Conference on the 19th May 2025.
Attendence is FREE thanks to our amazing sponsors: @biologists.bsky.social @10xgenomics.bsky.social and Azenta.
Research Assistant/Associate Position in the lab. Fully funded until February 2028. Please apply if you are passionate about inter-organ signalling and intestinal biology...And off course, our wonderful Drosophila!
Position details and application link below
www.jobs.gla.ac.uk/job/research...
Top Trumps - but make it science 🤓 I had the most fun designing these, and I've written about how you could use it in your outreach programme!
I'm keen to spread the word to any educators/academics who might be interested - please share 🤗 @nc3rs.bsky.social
thenode.biologists.com/biological-r...
"We report that numerous “miRNAs” previously reported in EMT and cancer contexts are not incorporated into RISC and are not capable of endogenously silencing target genes, despite the fact that hundreds of publications in the cancer field describe their roles"
www.biorxiv.org/content/10.1...
Thanks for the warm welcome! She is indeed, @kyracampbelllab.bsky.social
