3/3. One half-marathon per year of ID fellowship completed. Seattle, Vancouver, Lake Sammamish. β β β
07.03.2026 22:24
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3/3. One half-marathon per year of ID fellowship completed. Seattle, Vancouver, Lake Sammamish. β β β
Emerging risk factors for IFI in HCT. Climate change, older/comorbid recipients, antifungal prophylaxis, changes in GVHD prophylaxis and treatment, longer survivorship, agricultural use of antifungals
Invasive Fungal Disease in Allogeneic Hematopoietic Cell Transplantation: New Risk Factors and New Therapeutic Options in a Changing World
@abbydouglas.bsky.social & Monica Slavin
doi.org/10.1111/tid.... #TxID #IDSky #MedMycoSky
Candida Endocarditis: current perspectives on diagnosis and therapy
Ben-Ami Ronen, Bassetti Matteo, Bouza Emilio, Kosman Alex, Vena Antonio on behalf of @efisg-escmid.bsky.social
www.clinicalmicrobiologyandinfection.com/article/S119... #MedMycoSky #IDSky
Pathogenesis of Mucormycosis, Host Defenses, and Potential Future Therapeutic Targets. Mucorales sporangiospores released into the air from sporangia are inhaled, and the sporangiospore coat protein CotH3 binds to GRP78 on the pseudostratified columnar epithelial cells of the upper resp tract, where the sporangiospores may germinate into hyphae to invade nasal airways and sinuses (Panel A). Sporangiospores, by means of another coat adhesin (CotH7), also bind to epidermal growth factor receptor (EGFR) and integrin Ξ±3Ξ²1 receptor on pulmonary alveolar epithelial cells of the lower respiratory tract, which triggers a downstream transcriptional response involving cytokines (interleukin-6 and interleukin-8), chemokines (CCL2 and CCL5), and intercellular adhesion molecule 1 (ICAM-1). Hyphal invasion also triggers production of hypoxia-inducible factor 1Ξ± (HIF1Ξ±) and release of proinflammatory cytokines. In wound-related mucormycosis, traumatic inoculation of fungal elements (found on the surfaces of rocks, wood, glass, and metal) into damaged tissue allows for the development of infection in a host with immune paralysis due to trauma. The release of endogenous host-derived molecules known as damage-associated molecular patterns (DAMPs) reduces phagocytosis, impairs chemotaxis, and induces immune paralysis. Mucoricin released by the invading hyphae induces death of immune and endothelial cells, which results in tissue necrosis and accelerates endovascular thrombosis, ischemia, and infarction (Panel B). PMNs and monocytes recognize early germinated sporangiospores by pattern recognition receptors (e.g., TLR2) that detect mucorales-associated molecular patterns (e.g., 1,3-Ξ²D-glucans exposed on hyphal structures). Intrinsic host colony-stimulating factors such as granulocyteβmacrophage colony-stimulating factor (GM-CSF) and IFN-Ξ³ further contribute to augmentation of innate host defenses against the invading hyphae, which in turn dampen immune responses. Factors in the tissue β¦
Risk factors for Mucormycosis
Risk factors for mucormycosis continued
Mucormycosis
Review in @nejm.org by Dimitrios Kontoyiannis and Tom Walsh
www.nejm.org/doi/10.1056/...
#IDSky #TxID #MedMycoSky @msgerc.bsky.social
A π΅οΈ was in this case investigation:
While performing investigation of water system in pt w/ Legionella, infection control found an unregistered water flosser.
They ran sterile water through flosser and Legionella grew + matched infection strain
wwwnc.cdc.gov/eid/article/...
#IDSky
Invasive fungal diseases remain a major cause of morbidity and mortality in patients undergoing transplant, with shifting epidemiology, emerging resistance, and geographic variation underscoring the urgent need for improved surveillance, prevention strategies, and antifungal stewardship.
From a dear friend and colleague Dr Emily Rosen. Amazing work!
Current Epidemiology and Infection Characteristics of Non-Aspergillus Mold Infections: A Multicenter Study in Australia and New Zealand
β
Just Accepted
π https://bit.ly/4bLllbS
Valley Fever in Central California: Diagnosis is Not the Finish Line, the Real Gap is Longitudinal Care
β
Just Accepted
π https://bit.ly/4pWxxdk
One Health approach requires collaboration between researchers, physicians, engineers, ecologists, plant health experts, and other disciplines to tackle the spread of mycoses.
Potential applications of AI in Mycology may include compound screening for antifungal drug discovery (top left), clinical trial design and execution (bottom right), fungal identification (top right), and outbreak surveillance (bottom right).
Emerging Frontiers in Clinical Mycology: Innovations, Insights, & Impacts
Our report, led by @annaapostolopoulou.bsky.social, on the cutting edge of clinical mycology & future directions, from expert discussion @ the 2024 @msgerc.bsky.social biennial meeting
onlinelibrary.wiley.com/doi/10.1111/...
Aspergillosis-Attributable Mortality in the United States: Analysis of Death Certificate Data
β
Just Accepted
https://bit.ly/3M4ZVM8
New Review
British Society for Medical Mycology best practice recommendations for the diagnosis of serious fungal diseases: 2025 update
www.thelancet.com/journals/lan...
Aerosolizing pathogens from sink drains? New study shows it can happen & possibly cause transmission
Drain biofilm bacteria found in droplets and aerosols βΆοΈ spread into room
Possible sources of HAIs #IDSky
π: www.ajicjournal.org/article/S019...
Getting infected πβπ«ππβπ«
Bipolaris hawaiiensis , never heard of this before! Cool case!
UW fellows at IDWeek! π
@jerricawerner.bsky.social
Iβve made it!! #firstimer really excited to connecting with the ID community!!
Study from Iran suggesting nosocomial transmission of A Flavus. Pretty cool.
As a person who likes to jump in the lakes after a hike, this is a fun read!
@paulpottingermd.bsky.social
8 Gross Things Lurking in Swimming Holes
rightasrain.uwmedicine.org/life/leisure...
Donβt miss the educational opportunities at UWβs Infectious Diseases Education & Assessment (IDEA) site:
- National HIV Curriculum
- National STD Curriculum
- National PrEP Curriculum
- HCV Online
- HBV Online
#IDSky #MedSky
idea.medicine.uw.edu
Antimicrobial optimization based on negative results from both BFP and respiratory culture may potentially reduce unnecessary antibiotic exposure and AKI in hospitalized patients with suspected pneumonia without increasing the risk of mortality and readmission. doi.org/10.1017/ash....
Co-authored by UWβs Dr. Nina Kim and (oops) new from @cidjournal.bsky.social :)
Also check out UWβs IDEA HCV βTest and Cureβ curriculumβ¦ #IDSky
www.hepatitisc.uw.edu
Will be there!
Awesome! Thank you!
ππ₯Streptococcal endocarditis: a meta-analysis of species dependant risk by πs @drtoddlee.bsky.social
πUpdated figure πInfective endocarditis prevalence of streptococcal species vs. proportion of streptococcal species bacteraemia #idsky #EMIMCC
www.sciencedirect.com/science/arti...
#TB #meningitis guidelines #IDSky #MedSky
Itβs so cool you remember! <3
Iβm going! Presenting a poster on Wednesday on Invasive Fusariosis in IC hosts
Big fan