fightfungus.org/when-its-tim...
27.02.2026 22:19
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Table of recommendations part 1
Table of recommendations part 2
Fungal diagnostic stewardship in immunocompromised populations: a focus on molds and dimorphic fungi
@jmsteinbrink.bsky.social @hannah-imlay.bsky.social et al on behalf of @msgerc.bsky.social
journals.asm.org/doi/10.1128/... #IDSky #MedMycoSky #MicroSky #TxID
Our new review article on #iatrogenic #mold #cns #infections #IDSky #MedSky @msgerc.bsky.social journals.asm.org/doi/10.1128/...
Pathogenesis of Mucormycosis, Host Defenses, and Potential Future Therapeutic Targets. Mucorales sporangiospores released into the air from sporangia are inhaled, and the sporangiospore coat protein CotH3 binds to GRP78 on the pseudostratified columnar epithelial cells of the upper resp tract, where the sporangiospores may germinate into hyphae to invade nasal airways and sinuses (Panel A). Sporangiospores, by means of another coat adhesin (CotH7), also bind to epidermal growth factor receptor (EGFR) and integrin Ξ±3Ξ²1 receptor on pulmonary alveolar epithelial cells of the lower respiratory tract, which triggers a downstream transcriptional response involving cytokines (interleukin-6 and interleukin-8), chemokines (CCL2 and CCL5), and intercellular adhesion molecule 1 (ICAM-1). Hyphal invasion also triggers production of hypoxia-inducible factor 1Ξ± (HIF1Ξ±) and release of proinflammatory cytokines. In wound-related mucormycosis, traumatic inoculation of fungal elements (found on the surfaces of rocks, wood, glass, and metal) into damaged tissue allows for the development of infection in a host with immune paralysis due to trauma. The release of endogenous host-derived molecules known as damage-associated molecular patterns (DAMPs) reduces phagocytosis, impairs chemotaxis, and induces immune paralysis. Mucoricin released by the invading hyphae induces death of immune and endothelial cells, which results in tissue necrosis and accelerates endovascular thrombosis, ischemia, and infarction (Panel B). PMNs and monocytes recognize early germinated sporangiospores by pattern recognition receptors (e.g., TLR2) that detect mucorales-associated molecular patterns (e.g., 1,3-Ξ²D-glucans exposed on hyphal structures). Intrinsic host colony-stimulating factors such as granulocyteβmacrophage colony-stimulating factor (GM-CSF) and IFN-Ξ³ further contribute to augmentation of innate host defenses against the invading hyphae, which in turn dampen immune responses. Factors in the tissue β¦
Risk factors for Mucormycosis
Risk factors for mucormycosis continued
Mucormycosis
Review in @nejm.org by Dimitrios Kontoyiannis and Tom Walsh
www.nejm.org/doi/10.1056/...
#IDSky #TxID #MedMycoSky @msgerc.bsky.social
Free interactive training on neglected fungal diseases
ππ
www.train.org/cdctrain/cou...
On behalf of @efisg_escmid
ππ
gbr01.safelinks.protection.outlook.com/?url=https%3A%β¦
One Health approach requires collaboration between researchers, physicians, engineers, ecologists, plant health experts, and other disciplines to tackle the spread of mycoses.
Potential applications of AI in Mycology may include compound screening for antifungal drug discovery (top left), clinical trial design and execution (bottom right), fungal identification (top right), and outbreak surveillance (bottom right).
Emerging Frontiers in Clinical Mycology: Innovations, Insights, & Impacts
Our report, led by @annaapostolopoulou.bsky.social, on the cutting edge of clinical mycology & future directions, from expert discussion @ the 2024 @msgerc.bsky.social biennial meeting
onlinelibrary.wiley.com/doi/10.1111/...
Where is the field of #medical #mycology heading? Great write up by @msgerc.bsky.social #IDSky onlinelibrary.wiley.com/doi/10.1111/...
New webinar on fungal diagnostics!
Link in next post
Sign up here ππ
MSGERC is pleased to announce its fifth Biennial meeting!
We cordially invite you to this educational event for those seeking to diagnose, prevent, treat, and cure invasive fungal infections.
9-11 September 2026 in beautiful Colorado
Going to @idweek.bsky.social?
Join us for the MSG reception!
Register at msgerc.wildapricot.org/event-6217095
My specialist interest is serious fungal infection
Yes seriously..
Did you know fungi kill nearly 4 MILLION people each year?
I got to talk all about it with the "Pestpodden" podcast in Norway! π³π΄
podcasts.apple.com/no/podcast/p...
Tomorrow!
Get up to date on invasive candidiasis management
Register here π
funguseducationhub.org/closing-gaps...
New Molecular Diagnostics CME Course!
www.funguscme.org/AMT2025/inde...
Great news! @msgerc.bsky.social has just launched a new Dr Fungus App. All of the great information that is on the website is now on a (very) easy to use app put together by Matt Pullen. Apple (L) and Google (R) play store QR codes below.
Tomorrow at #TIMM2025 in Bilbao!
π 4:15β5:45 PM
π @rosannesprute.bsky.social opens YECMM Clinical Research (Room 0A)
π @salmantongarcia.bsky.social kicks off βDiagnostic challenges in low-resource settingsβ (Room 0C)
Donβt miss it!
CME Registration Open: Closing Gaps in Invasive Candidiasis Care
register here π
t.co/jAOxUx4VKh
The new Dr. Fungus app is now available on all iOS and Android/Google devices! This app serves as a handy companion to the Dr. Fungus website, providing quick, easy access to information on fungal organisms, medical mycoses, and antifungal medications!
It's Fungal Disease Awareness Week!
Did you know that fungal infection kills many millions of people every year?
The MSG is dedicated to tackle this problem through education and research
Be aware! We are in the Fungal disease awareness week!
funguseducationhub.org/closing-gaps...
funguseducationhub.org/best-practic...
