Sharpe Lab

Pervanadate: So much more than a protein tyrosine phosphatase inhibitor @babrahaminst.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

Pervanadate-induced oxidation relieves autoinhibition of the protein tyrosine kinase SRC A widely used tyrosine phosphatase inhibitor also oxidizes and activates the tyrosine kinase SRC.

Pervanadate is more than just a phosphatase inhibitor!

Read our paper just published in #sciencesignaling showing that pervanadate oxidises and activates SRC kinase too.

Link: tinyurl.com/5ype7e2s

Thanks for the 'focus' by: @nshahlab.bsky.social tinyurl.com/54fcjds3

@babrahaminst.bsky.social

We are hiring a research assistant 👉 tinyurl.com/yxebtjbj to join our lab working on healthy #ageing and protein #aggregation in C. elegans 🪱. Deadline August 4th. 🙏 RT. #proteostasis @babrahaminst.bsky.social

We’re excited to share a new pre-print from the lab! Led by Carmen Ramirez Moncayo and a fantastic collaboration with several groups from across @mrc-lms.bsky.social & @imperialcollegeldn.bsky.social. Interested in #OvarianCancer, #PARPinhibitors or #DrugDistribution? please read on! bit.ly/45lpekS

'Rapper Rhodopsin' (AKA Ellie @trayon.bsky.social lab) and the Babraham Massive celebrating Ellie's victory in the first ever @eu-life.bsky.social Science Vision contest. We're so proud! Thanks @ceitec.eu - it was so much fun!

The @babrahaminst.bsky.social rock steady crew in Brno at the @eu-life.bsky.social Communuty Meeting

Phill Hawkins and Len Stephens with Babraham Hall in the background

That's the end of the Signalling Symposium and the end of an era. To quote Phill's closing words: "It's been a hell of a journey." Thank you to everyone for attending and making it such a fitting tribute.

Cellular signals for health & disease A symposium marking the contributions of Len Stephens and Phillip Hawkins

📢 Calling all Signallers! Join us for this celebratory smorgasbord of signalling research on 1-2 May with sessions on #proteostasis, #PI3K, #autophagy, #redox biology and #nuclear signalling. 🧪

Latest Institute research with special guests ⤵️

www.eventbrite.co.uk/e/cellular-s...

Phosphatases: from basic research to translation Phosphatases have been considered undruggable for decades. However, recent breakthroughs with the first small molecule phosphatase inhibitors for cancer immunotherapy now in clinical trials have resu…

If you’re thinking of what meeting to go to this year then check out the #phosphatase meeting in Würzburg. Lots of great speaking slots and events for junior researchers. It’s always a fun meeting meetings.embo.org/event/25-pho...

BBSRC NWD: Structural Proteomics to spatially resolve interactions with mechanosensitive synaptic scaffold proteins at University of Liverpool on FindAPhD.com PhD Project - BBSRC NWD: Structural Proteomics to spatially resolve interactions with mechanosensitive synaptic scaffold proteins at University of Liverpool, listed on FindAPhD.com

*Fully funded PhD position available in the lab*

We will use structural proteomics to map the mechanosensitive interactions of talin in dendritic spines and how they change during long term potentiation.

Please share, and email for details :)

www.findaphd.com/phds/project...

Phosphatases: from basic research to translation Phosphatases have been considered undruggable for decades. However, recent breakthroughs with the first small molecule phosphatase inhibitors for cancer immunotherapy now in clinical trials have resu…

Join us in Würzburg, Germany, for the EMBO workshop “Phosphatases: From basic research to translation”! July 27-31 2025. Newest developments in the field, from academia and industry. Great networking opportunities! Short talk slots available. Hope to see you there! meetings.embo.org/event/25-pho...

www.nature.com/naturecareer...

New science leadership opportunities at the Babraham Institute