Joana Verissimo Ferreira

Single-cell spatial proteomics maps human liver zonation patterns and their vulnerability to disruption in tissue architecture - Nature Metabolism Using the single-cell Deep Visual Proteomics technique, the authors develop a resource providing spatially resolved proteomic analysis of individual cells in human liver tissue.

Ever wondered how the human liver looks like at single-cell, spatial protein resolution? We used single-cell Deep Visual Proteomics to map human liver zonation at the protein level - one hepatocyte at a time. Our paper is out in @natmetabolism.nature.com! www.nature.com/articles/s42...

C-COMPASS: a user-friendly neural network tool profiles cell compartments at protein and lipid levels - Nature Methods C-COMPASS is an open-source software designed to predict the spatial cellular distribution of proteins and lipids from cellular organelle profiling using a neural network-based regression model.

I‘m excited to announce that our paper has just been published in 𝑁𝑎𝑡𝑢𝑟𝑒 𝑀𝑒𝑡ℎ𝑜𝑑𝑠.

Here, we provide a solution for analyzing subcellular proteomics datasets and extend it to predict lipid localizations as well.

#proteomics #lipidomics #bioinformatics #systemsbiology

www.nature.com/articles/s41...

C-COMPASS: a user-friendly neural network tool profiles cell compartments at protein and lipid levels - Nature Methods C-COMPASS is an open-source software designed to predict the spatial cellular distribution of proteins and lipids from cellular organelle profiling using a neural network-based regression model.

🚀 Excited to share new work from Daniel Haas. In collaboration with Jan Hasenauer and Daniel Weindl within
@batenergy.bsky.social we've developed a software tool to map protein and lipid localization in cells, making spatial biology more accessible
www.nature.com/articles/s41...

Pex30-dependent #membrane contact sites maintain ER lipid homeostasis, say Joana Veríssimo Ferreira (@joanavferreira.bsky.social‬), Pedro Carvalho @dunnschool.bsky.social‬ @ox.ac.uk‬ and colleagues: rupress.org/jcb/article/...

@labvanni.bsky.social‬
#lipid #Organelles #Genetics #ER_literature

We uncovered a new phosphatidic acid (PA)-binding domain in Pex30 essential for its localization and normal PA distribution. Plus, Pex30 phosphorylation tunes its activity in response to metabolic cues.

This regulation is key for membrane contact site maintenance and overall cell homeostasis.

Excited to share the new work from the Carvalho lab @dunnschool.bsky.social! 🎉This was part of my PhD & a collaboration with the @labvanni.bsky.social & Ernst labs!

Big thanks to everyone involved! 🙌 @jcb.org

Read more: doi.org/10.1083/jcb.... (1/2)

Last opportunity to submit your abstract before talk selection! Great opportunity to present your work if you are a PhD student or postdoc...

Application review for the 2025 Gordon Research Conference on Molecular Membrane Biology begins on Feb 1. Maximize your chance of acceptance by submitting your application with an abstract before that date! Details: shorturl.at/MqKky and shorturl.at/lYbBM

I finally have made the move to Bluesky! 🙂
I hope to find cell biology/biochemistry content soon. Let me know if you have good suggestions.