Andrau Lab (@andraulab)

Don't miss our 'Genome Dynamics and RNA biology' axis symposium on March 17th!

06.02.2026 16:27 👍 1 🔁 0 💬 0 📌 0

Don't miss the launching of our BIOLuM scientific axis, 'Genome Dynamics and RNA Biology' on the CNRS campus,next March 17th!

06.02.2026 14:42 👍 1 🔁 0 💬 0 📌 0

Extracellular matrix stiffness modulates nuclear lamina organisation and sets nuclear conditions for PRC2 repression Capability of cells to respond to tissue-level elasticity has important physiological and pathological implications. Stiffening of the extracellular matrix (ECM) promotes invasive behaviour of cancer cells, supports the transformation of fibroblasts into cancer-associated fibroblasts and primes stem cell differentiation programs. Here, we investigated how ECM stiffness modulates the Nuclear Lamina (NL) and its impact on gene expression programs, epigenetic marking and 3D genome organisation. By combining hydrogel cell culturing of primary fibroblasts, genomics and super-resolution microscopy, we found that ECM stiffness modifies composition of the NL, modulates long range chromatin interactions, induces changes in chromatin motion and regulates thousands of genes. We identified a specific set of genes coding proteins involved in pathways related to mechanical adaptation such as adhesion and signalling. These genes harbour an apparent bivalent chromatin signature and are expressed under soft condition while repressed in stiff condition through Polycomb Repressive Complex 2 (PRC2). We found that this stiffness-specific repression is tempered by mechano-transduction and the NL. This work uncovers mechano-dependent NL composition, changes in 3D genome organisation and in chromatin motion which underlie adaptative gene expression programs controlled through PRC2. ### Competing Interest Statement The authors have declared no competing interest. Agence Nationale de la Recherche, ANR-18-CE12-0019 Fondation ARC pour la Recherche sur le Cancer, PJA-2018 La Ligue Contre le Cancer, https://ror.org/00rkrv905 Cancéropôle Grand Sud-Ouest, https://ror.org/058h5ns38, N°2022-E07 / CANCÉROPÔLE GSO

Latest preprint of the team, when Polycomb meets Lamin domains in mechanical stress regulation...
www.biorxiv.org/content/10.1...

29.01.2026 10:27 👍 7 🔁 4 💬 0 📌 1

DNA methylation and lncRNA control asynchronous DNA replication at specific imprinted gene domains - Nature Communications It is not fully understood why genomic loci show asynchronous DNA replication. Here, the authors show that two imprinted gene domains replicate asynchronously between the parental chromosomes due to d...

Latest collaborative publication of the team, when replication timing follows imprinting patterns... Congrats to all to Robert feil and Colleagues in particular!
www.nature.com/articles/s41...

29.01.2026 10:21 👍 2 🔁 1 💬 0 📌 0

🧬 Avancée majeure issue d’Abivax et de l’équipe Tazi @igmm-montpel.bsky.social @cnrs.fr @umontpellier.bsky.social @cnrsbiologie.bsky.social
Le 23 juillet 2027, Abivax annonce des résultats très positifs en phase 3 pour obefazimod contre la RCH.
📈 +520 % en bourse @lemonde.fr

25.07.2025 08:48 👍 7 🔁 3 💬 1 📌 1

Thank you Charlène!

23.07.2025 10:40 👍 0 🔁 0 💬 0 📌 0

Thanks neighbours!

23.07.2025 10:39 👍 0 🔁 0 💬 0 📌 0

G-quadruplexes are promoter elements controlling nucleosome exclusion and RNA polymerase II pausing - Nature Genetics This study examines the function of G-quadruplex DNA secondary structures in mammalian promoters, revealing that they represent core promoter elements contributing to gene regulation by nucleosome exc...

Sure, here it is: www.nature.com/articles/s41...

23.07.2025 10:38 👍 1 🔁 0 💬 0 📌 0

🤣🤣 Thank you very much Daan. Looking forward for the next one! 😉

22.07.2025 18:59 👍 0 🔁 0 💬 0 📌 0

Two major events today on our campus!
🚴‍♀️First, the Tour de France is passing right next to us — @cnrsoccitanieest.bsky.social!
🧬Second, our latest paper on the role of G-quadruplexes (G4s) at promoters is now online at @natgenet.nature.com!

22.07.2025 12:25 👍 25 🔁 6 💬 4 📌 1

Andrau Lab

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