Charlie Arber

I did it. Phew. 🏃‍♂️

I completed the Silverstone half marathon, raising money for Race Against Dementia.

Still time to donate if you have a spare £.

www.givengain.com/project/char...

What Rosalind Franklin truly contributed to the discovery of DNA’s structure Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.

If I see one more stupid Rosalind Franklin take I'm going to lose my mind. Thank god for @matthewcobb.bsky.social and @nccomfort.bsky.social. www.nature.com/articles/d41...

and another 👻 entry for #fluorescencefriday courtesy of Nadia Haghbin and Shaz

"Scroll to see examples of good and bad hPSC morphology"

Catching changes in morphology of your human pluripotent stem cell (hPSC) maintenance cultures early helps ensure reproducible, reliable experiments.

But what should you look for?

✨ It's happening again! 🚀 Registration for Stem Cells in Neuroscience 2026 has officially opened! 🧠 Don't miss your chance to attend this exciting event with great keynote speakers, thought-provoking workshops and ample networking opportunities 👉🏼 www.stemcelltuebingen.com #neuroscience #stemcells

Thank you @alzsocresearch.bsky.social and @dementiaresearcher.bsky.social for chatting with me about our recent paper.

So grateful for all the coauthors and mentors who made this work possible.

Certainly a team effort!

Thanks so much for the support Patrick. It is at Silverstone. So hopefully a quick pit stop for some new wheels half way.

Join Me in the Race Against Dementia I’m excited to run my first half marathon around the track at Silverstone. I am doing this to support Race Against Dementia, a charity that holds special significance for me and which began with Sir J...

Eeek. I've signed up to run my first ever half marathon, raising money for Race Against Dementia, funders for research into dementia.

Any contributions very much appreciated and any tips even more so! 🏃‍♂️🍝

www.givengain.com/project/char...

Key differences between visual- and memory-led Alzheimer’s discovered Differences in the distribution of certain proteins and markers in the brain may explain why some people first experience vision changes instead of memory loss in Alzheimer’s disease, finds a new…

Differences in the distribution of certain proteins and markers in the brain may explain why some people first experience vision changes instead of memory loss in Alzheimer’s disease, a study by @uclqsion.bsky.social researchers found.
buff.ly/dBRRQvY #WorldAlzheimersMonth

SuStaIn has the potential to really help clinicians with Alzheimer’s diagnoses, which in turn is beneficial for patients who get more personalised advice when it comes to making care plans.

🧠 This #WorldAlzheimersMonth, discover how UCL’s AI tool SuStaIn is transforming Alzheimer’s diagnosis and care—by identifying subtypes and predicting progression from just a snapshot of data.
buff.ly/DmzYSlb @uclengineering.bsky.social

So much in here for dementia researchers to take note of!

Out now on biorxiv! Excited to share our latest collaborative work investigating the earliest stages of Parkinson’s disease.

www.biorxiv.org/content/10.1...

Thanks to all the amazing co-authors Melissa Grant-Peters @jsbeckwith.bsky.social @stevethechemist.bsky.social Mina Ryten Sonia Gandhi

Excited contribute to this year’s lunch hour lecture program! It’s a free event and accessible to a non-specialist audience so please come and join me :)

Post a non-religious photo you think of as holy

These are the most challenging times for early-career scientists and engineers.

My team is doing its bit to help by maintaining and even expanding our database of funding opportunities for early-career researchers.

We found 437 of them.

Download it freely here: research.jhu.edu/rdt/funding-...

Reconstructing Alzheimer’s disease one cell type at a time using in vitro tricultures In a recent study, Lish and colleagues used a fully human-based, induced pluripotent stem cell (iPSC)-derived triculture model of neurons, astrocytes,…

I’m a huge fan of the work done by @typlab.bsky.social - so it was great to have the opportunity to write a preview of their work describing an in vitro triculture model of Alzheimer’s (with @celarber.bsky.social & Tatiana). Check it out & go read their paper!

www.sciencedirect.com/science/arti...

What a treat to share a walkies and a BBQ with my colleagues.

The rain in the background caught us on the way home. But that’s normal for a British bbq, right?

First treatment for rare disease approved by UK medicines regulator The first ever treatment for the rare neurodegenerative disease Friedreich’s ataxia – for which UCL and UCLH led the UK trial – has been approved for use in the UK by the medicines’ regulator.

💊 First ever treatment for Friedreich’s ataxia – for which @uclqsion.bsky.social and UCLH led the UK trial – has been approved for use in the UK by the medicines’ regulator.
buff.ly/3dSwwzJ #ResearchersAppreciationDay

Woohoo. Congrats Steph.

'Stem Cells in Neuroscience' is returning to Tübingen, Germany.

SAVE THE DATE: February 25-27, 2026.
More info: stemcelltuebingen.com

Please share
#stemcelltuebingen2026

@dzne.science
@hih-tuebingen.bsky.social
@unituebingen.bsky.social
@tueneurocampus.bsky.social

Currently listening to Mina Ryten (@ukdri.ac.uk) describing advances towards improved transcriptomic maps, providing new insights into variant to function for Alzheimer’s disease 🧠 #MilnerSymp25

I've been really hoping to see more manuscript threads here on 🦋, so here comes one!!! This is brand new work from the lab that took us in very unexpected directions and to exciting findings led by the amazing @emily-hill.bsky.social. Preprint here www.biorxiv.org/content/10.1...
and 🧵below:

My first last author paper. Time for the posh whisky the lab got me! 🥃

Huge credit to @selinawray.bsky.social, and all authors who made this work possible.

Thanks also to @alzheimerssoc.bsky.social and @alzheimersresearchuk.org, and race against dementia who supported this work.

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis - Molecular Neurodegeneration Background Mutations in PSEN1 cause familial Alzheimer’s disease with almost complete penetrance. Age at onset is highly variable between different PSEN1 mutations and even within families with the sa...

It's out!

More than just making amyloid?
What if mutations in PSEN1 also predispose inflammation.

We asked if Alzheimer's disease mutations affect cytokine signalling using stem cell derived astrocytes. molecularneurodegeneration.biomedcentral.com/articles/10.....

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…

🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer’s disease through disrupted regulated intramembrane proteolysis - Molecular Neurodegeneration Background Mutations in PSEN1 cause familial Alzheimer’s disease with almost complete penetrance. Age at onset is highly variable between different PSEN1 mutations and even within families with the sa...

'Mutations in #PSEN1 predispose #inflammation in an #astrocyte model of familial #AlzheimersDisease through disrupted regulated intramembrane proteolysis'

Oliver J. Ziff... @selinawray.bsky.social & Charles Arber @uclqsion.bsky.social‬‬

molecularneurodegeneration.biomedcentral.com/articles/10....

New paper from the lab, under the leadership of @celarber.bsky.social !

Lecturer / Associate Professor - London, England job with University College London (UCL) | 12840324 About usThe Division of Biosciences at UCL is one of the world's foremost centres for research and teaching in the biological sciences. We have an out

🚨🚨Job Alert🚨🚨!! Neuroscience, Physiology and Pharmacology are recruiting a new lecturer/associate professor! an amazing opportunity to join our fantastic dept! @ucl.ac.uk @ucllifesciences.bsky.social @uclnpp.bsky.social post here:
www.nature.com/naturecareer...

Wow. What does this mean for Alzheimer’s disease? 🧐