Oliver Harschnitz

Huge congrats Anirban. Incredibly well done!

Huge congratulations to Jean-Laurent @casanovalab.bsky.social. Incredibly well-deserved!

We have a new paper out today from superstar Nora Herzog!

A virus that fluidizes the nucleus to enable replication!

Check it out here:

lnkd.in/e-xV8acK

This was an amazing collaboration with Ian Mohr and Angus Wilson

Congratulations to all awardees of ISSCR Early Career Impact Award but specially to @nmoris.bsky.social and @nicolasrivron.bsky.social with many thanks for their efforts to navigate and shape the ethical issues associated with the emerging field of a #SCEmbryoModels #SCBEM

Preprint Editors – Development's next step into the preprint landscape Summary: This Editorial announces a call for Preprint Editors in Development to help expand the journal's relationship with preprints by curating our ‘In preprints’ articles.

New from @dev-journal.bsky.social: we're launching a new initiative and hiring Preprint Editors to help navigate the growing world of preprints in developmental & stem cell biology

Join our community & shape the future of research

journals.biologists.com/dev/article/...

Had a great day at Human Technopole - lots of stimulating discussions with students and faculty and also, this should be a new standard, Aperol spritz after the seminar! @humantechnopole.bsky.social

It was a real pleasure to visit @unipv.bsky.social today, and big thanks to @kajastelab.bsky.social for hosting me. Especially rewarding to interact with the Kajaste lab and learn more about their exciting work on innate immunity and nucleic acid sensing.

Young PI Symposium 2026 Visit the post for more.

yo 🦋 NEURO SKY 📣 the website is live and registration open for the Young PI Symposium 2026 - the day prior to FENS Barcelona! @young-pi-neuro26.bsky.social

navigate challenges, sharpen leadership skills, make a roadmap together for generations of neuroscientists!
youngpisymposium2026.com

🧠 How do synapses control the proteins that shape memory and plasticity?
🔬 Erin Schuman (@maxplanck.de Institute for Brain Research) joins our “HT Seminars: Connecting Discoveries” series to explore how neurons produce proteins locally.
Register by 25 Feb 2026 👉 humantechnopole.it/en/training/...

Autoimmune neuroinflammation leads to neuronal death via MIF nuclease-mediated parthanatos Nature Neuroscience - Neuroinflammation triggers DNA damage and subsequent parthanatos-mediated neuron death. Inhibiting parthanatos in a mouse model of autoimmune inflammation is neuroprotective...

How does inflammation kill neurons, and what can we do about it? Check out our latest paper where we consider this question: rdcu.be/e4nfP.

GSK strikes 5-year deal with Jackson Laboratory focused on neurodegenerative disease research Pharma giant GSK is launching a five-year collaboration with The Jackson Laboratory–New York Stem Cell Foundation Collaborative (JAX-NYSCF) to advance human cellular models of neurodegenerative dis | ...

'Pharma giant GSK is launching a five-year collaboration with The Jackson Laboratory–New York Stem Cell Foundation Collaborative (JAX-NYSCF) to advance human cellular models of neurodegenerative diseases.'
www.fiercebiotech.com/research/gsk...

Incredibly proud of @nicolapalazzi.bsky.social who presented his interesting work on the use of hPSC-based models to study host-virus interactions in the brain during the @humantechnopole.bsky.social internal seminar. Exciting times ahead! #proudPI

Losing sleep over #iPSC transgene silencing after differentiation?
Same here.

Bright in iPSCs.
Gone after differentiation.

Our paper in @cp-cellstemcell.bsky.social maps what actually keeps expression on👇
www.cell.com/cell-stem-ce...
🔗 Free access (50 days):
www.sciencedirect.com/science/auth...

🧠 Looking for a #PhD at the crossroads of immunology and neurodegeneration?

🔬 1 fully funded PhD in our @harschnitz.bsky.social Group within the #MSCA -funded #IGNITION Doctoral Programme, connecting 10 institutions across Europe.

Apply by 1 April 2026 👉 humantechnopole.it/en/news/1-ph...

Development presents... Wednesday 25 February – 15:00 GMT/UTC Chair: Polina Kameneva Joaquín Navajas Acedo (University of Basel) ‘Spatiotemporal emergence of somatosensory neuron diversity’ Carlo Donato Caiaffa (Universidade de São Paulo) ‘Decoding the role of HNRNPH2 in neural development using brain organoids and antisense oligonucleotides’ Clarisse Brunet (Institut Curie) ‘Decoding the gliogenic switch: how human brain organoids reveal the secrets of glial cell fate’ #DevPres @dev-journal.bsky.social theNode.biologists.com/devpres The Company of Biologists logo Development logo QR code

📢Register for our #DevPres webinar on neurodevelopment

The webinar, chaired by Polina Kameneva, features talks from Joaquín Navajas Acedo @mads100tist.bsky.social, Carlo Donato Caiaffa & Clarisse Brunet @clarissebrunet.bsky.social.

🗓️25 February, 15:00 GMT/UTC

us02web.zoom.us/webinar/regi...

Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...

This is a fascinating paper that reveals defined and clear mechanism for a phenomenon that for some seemed unbelievable- the up regulation of genes paralogous to those with specific types of inactivating mutations. This is called transcriptional adaptation 1/ www.science.org/doi/10.1126/...

Undergrads seeking summer research experience in gene or cell therapy: there's a *paid opportunity* from @bsgct.bsky.social! Please apply before 27th Feb. Please see bsgct.org/undergraduate/ for details.

Please repost to help spread the word - thanks!

That’s a wrap on our yearly lab retreat. Watching this team have fun, collaborate, and build on each other’s ideas over the last three days has been amazing. Grateful for their brilliance, their kindness, and the collaborative spirit they bring to the lab each day!

A small polymerase ribozyme that can synthesize itself and its complementary strand The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

Ooooh. Cool new paper on origins of life. A simple 45-nucleotide RNA molecule that can perfectly copy itself.

www.science.org/doi/10.1126/...

Legnini Group - Human Technopole Laboratory for Molecular and Systems Biology of RNA   The Legnini Group at Human Technopole combines molecular and systems biology approaches to study gene regulation. We use synthetic biology and opt...

1/6 We're hiring! Fully funded postdoc position in my group
humantechnopole.it/en/research-...

Excited to co-host this conference with @marissascavuzzo.bsky.social and Steve Liberles focused on the peripheral nervous system -- No Brainer! Check out the amazing list of speakers and apply for one of the spots for this small, interactive meeting on the beautiful Janelia Campus at HHMI.

Congratulations on this interesting work. Very important for the field.

Still a few spots left, hurry up! @embo.org #workshop 🦠

The IGNITION PhD Programme is now open! We’re offering 13 fully funded PhD positions across 10 institutions in 8 EU countries to study immune mediated neurodegeneration.

If you're passionate about research, innovation & international collaboration, this is for you.

ignition-consortium.eu/home/

🚀 Introducing the "HT Seminars: Connecting Discoveries"! A new series bringing leading international researchers to Milan to explore what’s next in life sciences. Across disciplines, perspectives and technologies.

Calendar & Registrations 👉 humantechnopole.it/en/training/... #HTseminars

We are thrilled that our study on the evolution of gene regulation in mammalian cerebellum development – led by @ioansarr.bsky.social, @marisepp.bsky.social and @tyamadat.bsky.social, in collaboration with @steinaerts.bsky.social – is now out in @ScienceMagazine! www.science.org/doi/10.1126/...

Pre-assembly of biomolecular condensate seeds drives RSV replication Nature - Viral ribonucleoprotein–viral protein networks form pre-replication centres that nucleate viral factories and drive respiratory syncytial virus replication.

Now out in Nature! We visualize infection of the RNA virus RSV in real-time with single-vRNP resolution to understand how RSV establishes viral factories, biomolecular condensates that act as sites of viral replication. A huge collaborative effort led by Dhanushika Ratnayake!

rdcu.be/e1bBW

Dissecting gene regulatory networks governing human cortical cell fate - Nature Systematic screening of transcription factors reveals conserved mechanisms governing cortical radial glia lineage progression across primates and provides a framework for functional dissecti...

1/ Our new study, led by Jingwen Ding, examines the role of transcription factors during human neurogenesis to identify gene regulatory networks influencing cell fate, maturation, and subtype specification
www.nature.com/articles/s41...

Long-range chemical signalling in vivo is regulated by mechanical signals - Nature Materials Tissue stiffness mediated by Piezo1 is shown to regulate the expression of diffusive guidance cues in the developing Xenopus laevis brain, revealing a crosstalk between mechanical signals and long-ran...

Paper alert: Our study led by @evapillai.bsky.social and @sudimukherjee.bsky.social showing that mechanical properties of the #brain actively shape the molecular landscape during development and #axonpathfinding is finally out! www.nature.com/articles/s41... @pdncambridge.bsky.social @fau.de @MPZPM

Modelling co-development between the somites and neural tube in human trunk-like structures - Nature Cell Biology Makwana, Tilley et al. generate human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumb...

🥂Congratulations to @nmoris.bsky.social & co for their study in our journal generating human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumbar trunk.
bit.ly/3LoaXw2