Michael Tellier

meetings.embo.org/event/26-rna3
To all 3' end (and RNA, in general) enthusiasts. I'm organising a great conference in Oxford 7th-11th Sept with @lapassmore.bsky.social and Christine Mayr. The lineup of speakers is brilliant! Registration closes 4th May. Please consider it!

How do RNA molecules shape genome regulation in the nervous system? (AKAY_U26CASE) | Doctoral Training Partnership This is open to Home Fee Status candidates only. This PhD project will investigate how RNA modifications influence the activity of topoisomerase I (TOP1), a crucial enzyme that regulates DNA…

PhD position in our lab - 4-year funded by BBSRC and @nrpdtp.bsky.social in collaboration with @earlhaminst.bsky.social and Inspiralis Ltd. Open to UK fee qualifying students - UK citizens and citizens of Ireland (residency requirement), etc biodtp.norwichresearchpark.ac.uk/projects/how...

The "publish or perish" culture must perish. Scientists need time to think.

We just published our Slow Science Manifesto, where we argue that huge changes are needed in the way we fund, publish, and evaluate science.

Read more and sign here: www.slow-science.com

My PhD work has been published٩( 'ω' )و

Pol II transcription must be terminated at some point. What happens to the cell when Pol II cannot terminate transcription efficiently?

3. Given that NELF‑C is upregulated in several cancers, including colorectal cancer, our findings underscore the therapeutic potential of targeting the NELF complex.

Huge thanks to all the authors, including Yağız Öztürk in my lab, and the @royalsociety.org for funding!

2. The transcriptional termination defect is likely mediated by the redistribution of cleavage and polyadenylation factors (CPA) and transcription termination factors from the poly(A) site to the RNA polymerase II pausing site and by an increase in transcription elongation rate.

1. We found that a rapid loss of NELF-C, a subunit of the NELF complex regulating RNA polymerase II pausing, promotes a general transcriptional readthrough leading to transcription/replication conflicts and cell cycle arrest.

NELF prevents transcriptional readthrough into DNA replication zones in cancer cells - EMBO Reports Regulation of RNA polymerase II (Pol II) transcription is closely associated with cell proliferation. However, it remains unclear how the Pol II transcription program is rewired in cancer to promote u...

Extremely happy to share our latest research on the NELF complex in @emboreports.org done in collaboration with the groups of Dr Takayuki Nojima and Dr Yasukazu Daigaku in Japan.

link.springer.com/article/10.1...

One week left to apply for the postdoc position at MRC-LMB in Cambridge. Join our team for an exciting project on transcription-coupled splicing to understand human gene regulation 🧬 Feel free to get in touch directly
#postdoc #cryoEM #biochemistry

UK’s £8bn research fund faces “hard decisions” as it pauses new grants UKRI boss Ian Chapman said it had been told by the government to

Helpful update into UKRI and research council funding changes from Zoe Kleinman @zsk.bsky.social

But please more focus on 2 things...

1) Immediate effects (eg funding decisions expected in March)

2) Likely disproportionate effects on early career scientists

www.bbc.co.uk/news/article...

FindAPhD : Medical Research Council-funded DTP in Interdisciplinary Biomedical Research at University of Warwick Apply for a PhD: Medical Research Council-funded DTP in Interdisciplinary Biomedical Research at University of Warwick

Opportunity for doing a PhD in my lab under the MRC-DTP programme, working on redefining the role of signal peptidase complex in cellular signalling. warwick.ac.uk/fac/sci/life...
Deadline 2nd March 2026.
www.findaphd.com/phds/program...

Excited to share our new Nature study! 🧬

We (sidrituruci.bsky.social et al) discovered that CFAP20 helps clear stalled RNAPII, preventing harmful clashes with DNA replication machinery. This protects cells from R-loops and genome instability.

Full paper: www.nature.com/articles/s41...

PARG regulates the proteasomal degradation of TARG1 ADP-ribosylation (ADPr) is a reversible modification of macromolecules critical for the regulation of genome stability, stress responses, and proteost…

I am happy to have contributed to this study published in @cp-cellreports.bsky.social and led by @ahellab.bsky.social group, on the interplay between two ADP-ribosylation (ADPr) hydrolases TARG1 and PARG, revealing that PARG regulates TARG1 protein level.

www.sciencedirect.com/science/arti...

#30DayMapChallenge #30DayMapChallenge2025 #30DayMapChallengeRbanism #30DayMapChallengeR

Day 7: Accessibility.

Access, A Matter of Means.

by @ineszaid.bsky.social

#GeoData #rstats #DataViz #Maps #SpatialViz

Another exciting opportunity @dunnschool.bsky.social !

Come and be a colleague to a great group of scientists working on the fundamental mechanisms underlying disease, and how to transform health

Please help us find great applicants

Please add me as well. Thank you!

Hi everyone!
New to the community and thrilled to be starting a lab @warwicklifesci.bsky.social focused on the intersection of membrane protein biogenesis and gene regulation.
Looking forward to connect with fellow researchers.
#AcademicSky #NewLab #CellBiology #Science #Research #MembraneProteins

In this study, Mimoso et al. show that Restrictor serves as a transcriptional safeguard that suppresses the spurious transcription of non-coding RNAs, while preserving mRNA transcription.

Learn more here:
➡️ tinyurl.com/gd352654

Transcription and Chromatin UK is back! This time in Manchester, 17th-19th September. Send your abstract by 17th July for the opportunity to discuss your work with the UK RNA and epigenetics community, and with leading experts from abroad. Click the link below and spread the word!

EMBO Gold Medal 2025 awarded to Tanmay Bharat and David Bikard – Press releases – EMBO Every year, EMBO awards the Gold Medal to group leaders in the early stages of their careers for their remarkable contributions to the life sciences in

EMBO is delighted to announce that this year the EMBO Gold Medal is awarded to Tanmay Bharat @tbharat-lab.bsky.social ‬ @mrclmb.bsky.social and David Bikard @dbikard.bsky.social @pasteur.fr for their remarkable contributions to the #LifeSciences.

www.embo.org/press-releas...
#award 🧪

Nice perspective by Michael Nagel and Dylan Taatjes in @cp-molcell.bsky.social

Regulation of RNA polymerase II transcription through re-initiation and bursting

www.cell.com/molecular-ce...

Fast & Fair peer review: a pilot study demonstrating feasibility of rapid, high-quality peer review in a biology journal Traditional peer review is slow, often delayed by the time-consuming process of identifying reviewers and lengthy review turnaround times. This study tests the feasibility of the Fast & Fair peer revi...

Built a peer review system that doesn’t take forever.
Spoiler: scientists love it.
Huge thanks to the amazing team at The Company of Biologists for making Fast & Fair happen.
Read the preprint: bit.ly/4iZ30st
#biologists100 @biologists.bsky.social @biologyopen.bsky.social

I'm excited to share our latest publication on co-transcriptional RNA folding in a eukaryote! Great work by Leo Schärfen with collaboration from Isaac Vock and Matt Simon! @leoschaerfen.bsky.social @mattdsimon.bsky.social
Here is the link that works! authors.elsevier.com/a/1kpxo_Oylr...

Save the date! On March 25th, We'll dive into Nanofluidic tools for studying DNA repair with Fredrik Westerlund and R-loops & genome instability with Sidrit Uruci & Agnese Cristini. Don't miss out! 🗓️ #DNARepair #GenomeStability

Many life-saving drugs fail for lack of funding. But there’s a solution: desperate rich people Each year, hundreds of potentially world-changing treatments are discarded because scientists run out of cash. But where big pharma or altruists fear to tread, my friend and I have a solution. It’s re...

Interesting idea: get the sick super-rich to pay for clinical trials

Alternative idea: get the super-rich to pay tax that allows democratically accountable governments to support clinical trials (and research and healthcare and....)

www.theguardian.com/news/2025/ma...

We have an exciting collaborative #PhD project with Dr Catherine Jopling, University of Nottingham, on understanding the role of cancer-associated SF3B1 K700E mutation in microRNA expression and biogenesis.
Application deadline: 10th January 2025.

More information: more.bham.ac.uk/mrc-aim/phd-...

Excited to share our new paper @genomeresearch.bsky.social about PlatinumCRISPr thanks to @ihaussmann.bsky.social, @roliarnold.bsky.social, @davidmcquarrie.bsky.social & team.

sgRNA folding matters - our online tool PlatinumCRISPr selects correctly folded sgRNAs.

genome.cshlp.org/content/earl...

Unravelling age-related gene expression dysregulation through system biology and mathematical modelling. at University of Leicester on FindAPhD.com PhD Project - Unravelling age-related gene expression dysregulation through system biology and mathematical modelling. at University of Leicester, listed on FindAPhD.com

We have an exciting and multidisciplinary fully-funded BBSRC MIBTP #PhD position between my lab and Massimo Cavallaro's lab coupling genomics, transcriptomics, and mathematical modelling to investigate the regulation of gene expression.
Deadline: 16th January 2025.
www.findaphd.com/phds/project...

RNA Polymerase II subunits overexpressions induce genome instability and deregulate transcription Independently of the pathways or circuits deregulated in cancer cells, these present altered transcription patterns, often also direct consequence of deregulation of transcription factors. In this sen...

What happens when you overexpress one subunit of the RNA Pol II? Well, it depends on the subunit, but all deregulate transcription and induce genome instability @agagambus.bsky.social www.biorxiv.org/content/10.1...

Uncovering the mechanisms of epigenetic regulators using cutting-edge molecular biology and advanced imaging methodologies at University of Leicester on FindAPhD.com PhD Project - Uncovering the mechanisms of epigenetic regulators using cutting-edge molecular biology and advanced imaging methodologies at University of Leicester, listed on FindAPhD.com

🎓 Exciting #PhD opportunity in our lab at @mcbleicester.bsky.social and @leicstructbio.bsky.social. Join the BBSRC-funded MIBTP programme for a 4-year fully funded studentship with comprehensive training in year 1 + research project years 2-4. #PhDSky
#AcademicSky Details: tinyurl.com/4fhavzxh