liti_nice

The Multifaceted Role of Rad9 in the DNA Damage Response of Saccharomyces cerevisiae To maintain the integrity of the genome, cells have evolved a complex signalling system, termed the DNA damage response (DDR), which detects DNA damage and promotes DNA repair. To date, over 600 prot....

In the latest #Yeast review article, A. Kiely, F. O'Halloran, P. Young, N. F. Lowndes, @murielgalway.bsky.social and K. Finn discuss the latest advances in understanding the versatile role of Rad9 in the DNA Damage Response in Saccharomyces cerevisiae 🧬

onlinelibrary.wiley.com/doi/10.1002/...

Yeast | Microbiology Journal | Wiley Online Library Yeast is a microbiology journal for research in the rapidly moving field of yeast biology. We publish the most significant developments in unicellular fungi.

ANNOUNCEMENT: The webpage for the upcoming yeast meetings of 2026 has recently been updated. Have a look at it to find out which exciting #yeast #conferences are ahead!!! 😀

onlinelibrary.wiley.com/page/journal...

Compared to the preprint, we added data on the functional effect of the suppressors (about half are LOF). Thanks again to @leopoldparts.bsky.social @ptck72.bsky.social @markashe.bsky.social @nicolo-tellini.bsky.social and all co-authors without Bluesky accounts!

delighted to have contributed to this editorial led by Sakkie Pretorius on the wave of next generation #yeast scientist

📢 In our new study, we identify the predominant natural route to polyploidy in S. cerevisiae.

Stepwise polyploidization operates through iterative cycles of events termed "Sporulate–Endoreplicate–Mate" (SEM).

Really excellent work led by @cintiagomez.bsky.social 👏

www.biorxiv.org/content/10.6...

Very nice, congratulations

Ancient co-option of LTR retrotransposons as yeast centromeres - Nature Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with re...

Our paper is now out in Nature:

“Ancient co-option of LTR retrotransposons as yeast centromeres”

www.nature.com/articles/s41...

A short thread on how retrotransposons helped give rise to yeast point centromeres.

1/14

With @litinice.bsky.social, we built a haploid resource from 33 wild Taiwanese Saccharomyces cerevisiae strains — including some of the most genetically divergent Asian lineages — to bring natural yeast diversity into a genetically tractable framework. www.biorxiv.org/content/10.6...

There's a lot more juicy stuff inside so I hope you'll give it a read over at @currentbiology.bsky.social ! Thanks to my (Bluesky) coauthors @linder-surprise.bsky.social, @jlsteenwyk.bsky.social, @ana-pontes.bsky.social, @hittingerlab.bsky.social, & @rokaslab.bsky.social!

The deadline for the submission of papers to the special issue on the International Yeast Meetings of 2025 has been extended to 31 March. Papers should be connected to one of the meetings listed below. Hurry up and don't miss this chance!

More information at:
onlinelibrary.wiley.com/page/journal...

Last paper in collaboration with Zhou XU. We explored the natural telomere length diversity in S. cerevisiae and found that ploidy level, and subtelomere structure drive telomere length variation. Higher ploidy levels lead to telomere elongation! genome.cshlp.org/content/earl...

Sponges, ctenophores, and the statistical significance of syntenies Abstract. Shared fusions between ancestral chromosomal linkage groups have previously been used to support phylogenetic groupings, notably sponges with cni

@rcply.bsky.social argues that phylogenetic inferences in sponge–ctenophore–bilaterian relationships based on shared chromosomal rearrangements suffer from insufficient statistical support.

🔗 doi.org/10.1093/molbev/msaf321

#evobio #molbio

🤞

Last work of the lab showing that Repeated losses of self-fertility shaped heterozygosity and polyploidy in yeast evolution | PNAS www.pnas.org/doi/10.1073/...

Happy 40th birthday Yeast: Yeast: Vol 42, No 12 Yeast is a microbiology journal for research in the rapidly moving field of yeast biology. We publish the most significant developments in unicellular fungi.

The new year has just started and we are happy to share the news that the new issue of #Yeast (Volume 42, Number 12, December 2025) is finally out!!! 😀😀😀

This issue includes two research articles and two reviews.

You can browse it at this link:

onlinelibrary.wiley.com/toc/10970061...

Here is our first publication of 2026 which is the first article of a special issue that mark the journal 40 anniversary - happy new year to all the #yeast community

A global synthesis of yeast in microbiomes Yeasts are widespread members of microbial communities across terrestrial, aquatic, and host-associated environments, yet they remain underrepresented in microbiome studies due to low abundance and me...

here is our first contribution of yeast in microbiomes led by Jason Tsai group[ with contributions from Alberto and Nelly: www.biorxiv.org/content/10.6...
more to come

📢 Join us in sunny Lisbon 🇵🇹 2-5 June for the @embo.org workshop ☀️

“The rules of the game: biophysical & molecular principles in cellular evolution”

Apply by March 1st!
Please repost to help spread the word!

meetings.embo.org/event/26-cel...
#EMBORulesOfTheGame @gimmfoundation.bsky.social

Sponges, ctenophores and the statistical significance of syntenies Abstract. Shared fusions between ancestral chromosomal linkage groups have previously been used to support phylogenetic groupings, notably sponges with cni

Some more shenanigans on the Ctenophora Porifera debate from @rcply.bsky.social academic.oup.com/mbe/advance-...

🗞️ New preprint from the lab, led by our postdoc Ana Garoña (not on here) in collab with @andreagiometto.bsky.social: “Experimental evolution of cellular miniaturization reveals a mechanism for cell size evolution”, aka: “honey, we shrank the yeasts!” 🎥
www.biorxiv.org/content/10.6...

Le Dr Isheng Jason TSAI et le Pr. Gianni LITI avec leurs médailles au côté du Pr. Alain FISCHER, président sortant de l'Académie des sciences.

Le Grand Prix scientifique franco-taïwanais 2025 du Conseil National des Sciences de #Taïwan et de @academiesciences.bsky.social a été décerné à Gianni LITI, de l'Institut de recherche sur le cancer et le vieillissement de Nice, et Isheng TSAI, du Biodiversity Research Center de l'Academia Sinica.

So excited to see my PhD work finally being published!!!

It was such a pleasure working with a great team!!!

Congratulations to EMBO Member Tony Hyman on his appointment as the next Director General of EMBL! We look forward to working with him to strengthen European and global #LifeSciences.

Read more:
https://www.embo.org/features/embo-congratulates-new-director-general-of-embl/

From Yeast to Therapeutics: Modeling Neurodegenerative Diseases in Saccharomyces cerevisiae Yeast plasmids expressing human Aβ-42, α-syn, htt, and TDP-43. Their fate includes an equilibrium between the endocytic pathway and aggregates that potentially disrupt endocytosis, vesicular transpor...

In this #Yeast review article, Jose Ribamar Ferreira-Junior, Vittoria de Lima Camandona & Mario H. Barros show how Saccharomyces cerevisiae can be used as a model to study the cellular processes underlying #neurodegenerative disorders and to test new drugs 💊

onlinelibrary.wiley.com/doi/10.1002/...

18S and 25S Exonuclease Resistant Ribosomal RNA Molecules Are Produced by 5′‐End Modification During TOR Inhibition. Saccharomyces cerevisiae produces exonuclease-resistant rRNA molecules upon TOR inhibition. This phenomenon occurs when cells enter the diauxic phase, upon addition of rapamycin to the culture, or wh...

In the latest #Yeast research article, Miguel A. Rocha, Gowda Bhavani and Jacob Fleischmann investigate the role of exonuclease-resistant ribosomal RNAs in Saccharomyces cerevisiae, their relationship with nutritional status and the TOR signalling pathway.

onlinelibrary.wiley.com/doi/10.1002/...

Happy 40th birthday Yeast: Yeast: Vol 42, No 11 Yeast is a microbiology journal for research in the rapidly moving field of yeast biology. We publish the most significant developments in unicellular fungi.

The new issue of #Yeast of 2025 (Volume 42, Issue 11, November 2025) is out! It includes papers about new yeast genomes, the biodiversity of yeasts in dough, polyphosphate accumulation and even a new #FantasticYeasts species 😃

You can browse it at this link:

onlinelibrary.wiley.com/toc/10970061...

Polyphosphate Accumulation Is Determined by Zinc and Inositol in Saccharomyces cerevisiae Zinc and inositol supplementation during phosphate starvation significantly enhances final polyphosphate levels in S. cerevisiae.

In the latest #Yeast research article, Alexander Deitert, Lars M. Blank and team investigated the effect of zinc and inositol in polyphosphate accumulation in Saccharomyces cerevisiae, revealing their role in energy metabolism and phosphate signalling.

onlinelibrary.wiley.com/doi/10.1002/...

Characterization of Vector Elements and Soluble Expression of Pcv3 Cap Protein in Kluyveromyces Marxianus We engineered a vector system that was suitable for Kluyveromyces marxianus-based recombinant protein expression. Endogenous promoter PDC1 with high expression strength was used in this vector system...

In this new #Yeast research article Yueting Zheng, Wei Yang, Wei Zhang & teams developed a new expression vector system to produce exogenous proteins in Kluyveromyces marxianus, and they successfully expressed the cap gene of porcine circovirus type 3 (PCV3).

onlinelibrary.wiley.com/doi/10.1002/...

NEW GENOME ALERT 👇: in this new #Yeast research article
@dmattanovich.bsky.social , Brigitte Gasser, Alexandra B. Graf and team published the complete and annotated genome sequence of the Komagataella phaffii type strain, revealing new genes and SNPs.

onlinelibrary.wiley.com/doi/10.1002/...

Ever wondered what is in your Tarhana dough? In the latest #Yeast research article, Burcu Ozel, Bilal Agirman, Omer Simsek and Huseyin Erten investigated the effects of backslopping on the yeast and volatile aroma compound diversity of tarhana.

onlinelibrary.wiley.com/doi/10.1002/...