Jessica Rosarda

Congratulations to Prasanna Satpute-Krishnan (@pskcellbio.bsky.social)
for winning the USU Henry C. Wu Award for Excellence in Basic Science Research!

The ubiquitin E3 ligase HRD1 restricts hepatic lipid metabolism by suppressing PPARα-driven m6A RNA modification m6A modification of mRNAs promotes hepatic lipid metabolism and is blocked by HRD1-mediated ubiquitination.

Scientists have identified a protein that acts as a brake on the breakdown of lipids in the liver that’s regulated by both feeding and the circadian rhythm, according to new #ScienceSignaling research involving mice. https://scim.ag/4bkWSKf

JCB’s Cover of the Year voting is open!
I’ll just say… they are all gorgeous, but April has my heart 😍❄️🔬

#teamtomo @attychang.bsky.social

Defining the role of β-cell IRE1α/XBP1 pathway and its gene regulatory network components in non-obese diabetic mice - Nature Communications Modulating the unfolded protein response (UPR) can induce protective dedifferentiation of β-cells in non-obese diabetic mice. Here, the authors show that β-cell deletion of UPR transcription factor XB...

Our new paper is out now in Nature Communications! We uncovered the function of XBP1 in beta cells of a preclinical model of T1D and identified unique and shared gene regulatory networks driven by IRE1 and XBP1.

www.nature.com/articles/s41...

Enrichment: - YouTube

We took a modified doggy agility class designed for senior dogs from a place in DC. Some of the skills were- go through the tunnel at your own pace & step onto a wobbly board for a reward.They have lots of online material also: m.youtube.com/playlist?lis...

During RESET, misfolded GPI-APs traffic from the ER to the Golgi. Top left : Time-lapse imaging sequence collected immediately after thapsigargin (TG) treatment of a typical YFP-PrP * NRK cell that was co-expressing ER-marker, Cerulean-calnexin (CER-CNX). Scale bar represents 10 µm. Top right: Plot of the average Pearson’s r values between YFP-PrP * and CER-CNX for 9 individual cells across the 0 and 20 min time points of time-lapses collected after addition of TG. Bottom left: Time-lapse imaging sequence collected immediately after TG-treatment of a typical YFP-PrP * NRK cell that was co-expressing the Golgi marker, CER-GalT. Scale bar represents 10 µm. Bottom right: Plot of the average Pearson’s r values between YFP-PrP * and CER-GalT for 10 individual cells across the 0 and 20 min time points of time-lapses collected after addition of TG.

TMED9 mediates export of misfolded #prion proteins from the ER. @pskcellbio.bsky.social &co show that TMED9 also helps capture #misfolded GPI-anchored proteins that are released by calnexin in the ER and moved into the Golgi for degradation via the RESET pathway @plosbiology.org 🧪 plos.io/44kURu5

Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells Pathogenic variants in the mitochondrial outer membrane GTPase MFN2 cause the peripheral neuropathy Charcot-Marie-Tooth Type 2A (CMT2A). These mutations disrupt MFN2-dependent regulation of diverse as...

New work from the lab (w/ @preronabora.bsky.social @mashiatzaman.bsky.social @mitomorph.bsky.social @nanigrotjahn.bsky.social) identifying a compound that activates OMA1-DELE1-HRI signaling to induce mitochondrial remodeling in MFN2-deficient cells. Check it out 👇
www.biorxiv.org/content/10.1...

Bioconductor - Bioconductor 3.21 Released The Bioconductor project aims to develop and share open source software for precise and repeatable analysis of biological data. We foster an inclusive and collaborative community of developers and…

Bioconductor 3.21 released with 72 new software packages, for a total of 2341 software packages, 432 experiment data packages, 928 annotation packages, 30 workflows and 5 books bioconductor.org/news/bioc_3_... 🧬🖥️🧪 #Rstats

Xenotopic synthetic biology: Prospective tools for delaying aging and age-related diseases Using enzymes from lower organisms, which are not encoded in the mammalian genome, delays aging and age-related diseases.

Metabolic dysregulation is a driving force of aging.

Enzymes from lower organisms—such as bacteria and yeast—may be able to reverse age-associated metabolic changes in humans, a new #ScienceAdvances study finds.

Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity Pharmacological enhancement of endoplasmic reticulum (ER) proteostasis is an attractive strategy to mitigate pathology linked to etiologically-diverse protein misfolding diseases. However, despite thi...

Phenylhydrazone-based Endoplasmic Reticulum Proteostasis Regulator Compounds with Enhanced Biological Activity www.biorxiv.org/content/10.1...

Happy to share the first paper in my PhD is published in JCB!
It's my honor to work with amazing teammates! I really enjoy exploring mitochondrial protein import mechanism through cryo-ET!

Plasticity of the mammalian integrated stress response Nature - A study describes the split integrated stress response, a cellular stress response mechanism characterized by reduced eIF2B activity without eIF2α phosphorylation, which activates the...

Beautiful work by my colleague and friend Maria Hatzoglou 🎉

rdcu.be/efdpL