Dimitry Krementsov's Avatar

Dimitry Krementsov

@dimitry-krementsov

Immunologist and educator; faculty at UVM. Dad; foodie; lover of music.

164
Followers
206
Following
6
Posts
26.12.2024
Joined
Posts Following

Latest posts by Dimitry Krementsov @dimitry-krementsov

It's the genetic susceptibility to MS that's the missing piece. If you don't have the genetic risk, it doesn't matter if you get EBV. Hence the HLA-DR paper above. :)

18.01.2026 12:32 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Integrated multi-omics analysis identifies microbial and metabolic signatures and drivers of CNS autoimmunity Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) driven by genetic and environmental determinants. The gut microbiome of people with MS (pwMS) is distinct and influences disease through immunomodulatory metabolite production. Circulating metabolites are altered in pwMS, but identifying microbial-metabolic drivers remains challenging. We previously showed that colonization by the gut commensal Limosilactobacillus reuteri ( L. reuteri ) exacerbates disease in the experimental autoimmune encephalomyelitis (EAE) model of MS, in a tryptophan-dependent manner. Here, we integrated microbiomic and metabolomic datasets from a longitudinal EAE study utilizing high and low tryptophan diets in mice colonized or not with L. reuteri . Gut microbiome dynamics under short- and long-term alterations in tryptophan bioavailability, were affected by diet, microbiome context, or disease. During short-term dietary intervention, L. reuteri colonization exerted a greater impact on microbiome composition than tryptophan bioavailability. With longer dietary exposure and EAE progression, high dietary tryptophan and L. reuteri colonization synergized to elicit profound microbiota changes, including alterations in Lachnospiraceae, Blautia , and Akkermansia . Integration of metabolomic and microbiomic datasets using joint Robust Aitchison PCA revealed clusters of associated metabolites and microbiota enriched for functional pathways, including bile acid and tryptophan metabolism. Metabolites outperformed microbiota in predicting EAE severity, identifying p-cresols and indoles as top disease-associated metabolites. Treatment with p-cresol or 3-indoleglyoxylic acid exacerbated EAE, enhanced proinflammatory T cell responses, and increased cerebellar pathology. These data demonstrate that dietary responses are shaped by gut microbiome composition and that integrated microbiomic-metabolomic analyses can identify drivers of disease worsening in MS. IMPORTANCE MS is a multifactorial disease influenced not only by genetics but also by environmental factors, potentially including diet and the composition of the gut microbiome. We show that interactions between diet and commensal gut microbiota profoundly impact levels of immunomodulatory systemic metabolites, including several that are associated with disease in pwMS. Importantly, we demonstrate that individual gut microbiota produced metabolites are sufficient to worsen disease in a mouse model of MS. Integration of gut microbiome and blood metabolite datasets combined with subsequent predictive modeling, may bolster biomarker identification and the capacity to predict disease severity in pwMS, as compared to performance of individual datasets alone. These findings highlight metabolites as key mediators linking diet and the gut microbiota to neuroinflammation. Importantly, this work suggests that targeting microbial metabolites or modifying diet–microbiome interactions may represent new strategies to reduce disease activity in MS and related autoimmune disorders.

www.biorxiv.org/content/10.6...

17.01.2026 14:52 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0
Preview
Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses This study dissects the individual contributions of the different components of mRNA vaccines to immune responses. Nucleoside-modified mRNA promotes the production of type I interferons that act on de...

Distinct components of mRNA vaccines cooperate to instruct efficient germinal center responses: Cell
@devdoot.bsky.social
www.cell.com/cell/fulltex...

24.12.2025 17:48 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Preview
Gut Instincts: Decoding the Microbiome’s Role in Multiple Sclerosis | College of Nursing and Health Sciences | The University of Vermont Postdoctoral researcher Theresa Montgomery’s work is advancing science and sparking new collaborations, with potential to transform MS treatment.

Proud to share this story highlighting the awesome work of a postdoc fellow in my lab, Theresa Montgomery! "Gut Instincts: Decoding the Microbiome’s Role in Multiple Sclerosis" www.uvm.edu/cnhs/news/gu...

18.11.2025 20:09 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Post image Post image Post image

SCIENCE ON THE MOVE!

The march has reached HHS, where stacks of petitions are piling up!

FOLLOW ALONG ➑️
www.youtube.com/live/3Hi18Fv...

05.11.2025 21:27 πŸ‘ 164 πŸ” 37 πŸ’¬ 1 πŸ“Œ 1
Preview
Office Hours with Earth's Virology Professor Livestream 11/05/25 8 pm ET Join Vincent Racaniello for Office Hours to answer your questions about viruses - including SARS-CoV-2, Mpox virus, poliovirus, influenza virus, and more - on this livestream on Wednesday 11/05/25 at ...

See you in a few hours! 8pm πŸ‘‡

05.11.2025 21:34 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Comic. [Person sitting at desk with laptop with machine labeled E-21 making β€œclick click” noises on the floor behind] VOICE FROM LAPTOP: Hey all! Does your E-21 humidifier make an annoying clicking noise? Mine did, but I finally figured out that there’s an easy fix, so I made this video in case anyone else… PERSON AT DESK: Oh my god. Yes. *Yes.* [caption] I know there’s more important work in the world, but I feel like these people deserve, at minimum a statue.

Comic. [Person sitting at desk with laptop with machine labeled E-21 making β€œclick click” noises on the floor behind] VOICE FROM LAPTOP: Hey all! Does your E-21 humidifier make an annoying clicking noise? Mine did, but I finally figured out that there’s an easy fix, so I made this video in case anyone else… PERSON AT DESK: Oh my god. Yes. *Yes.* [caption] I know there’s more important work in the world, but I feel like these people deserve, at minimum a statue.

Repair Video

xkcd.com/3163/

05.11.2025 22:04 πŸ‘ 7169 πŸ” 1125 πŸ’¬ 77 πŸ“Œ 61
Post image

In this week's episode, we review the seminal study from Dr. Sakaguchi that led to his recent #NobelPrize!

It shows that a population of T cells expressing the IL-2 receptor Ξ± chain acts to maintain self-tolerance by suppressing other T cells.

πŸ“ƒ: https://bit.ly/49f551F
🎧: https://bit.ly/3LlRCeo

22.10.2025 18:57 πŸ‘ 5 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Preview
National Academy of Medicine Announces Election of Larner’s Dr. Peter Calabresi as New Member | Office of Medical Communications | The University of Vermont

Excited to have @pcalabresi.bsky.social as a new colleague! National Academy of Medicine Announces Election of (newly) UVM's Dr. Peter Calabresi as New Member www.uvm.edu/larnermed/me...

22.10.2025 20:20 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Preview
China’s Biotech Advances Threaten U.S. Dominance, Warns Congressional Report Congress should invest at least $15 billion to support biotech research over the next five years and take other steps to bolster manufacturing in the U.S., the report said.

This!!! I hope someone in Washington is listening

www.wsj.com/tech/biotech...

08.04.2025 22:48 πŸ‘ 306 πŸ” 108 πŸ’¬ 15 πŸ“Œ 5
Preview
Opinion | The Uncertain Fate of the Young American Scientist (Gift Article) Young researchers are choosing between staying in science and staying in the United States.

www.nytimes.com/2025/04/03/o...

Really important piece to share widely. Too many Americans don’t know how severe a threat this Administration poses to our scientific infrastructure, global leadership, and health security

04.04.2025 07:32 πŸ‘ 476 πŸ” 303 πŸ’¬ 18 πŸ“Œ 56
Hands off our science protests today across the country

Hands off our science protests today across the country

It's Hands Off Day!

Make sure you review protest safety before you hit the streets today: standupforscience2025.org/protest-safe...

Find an event near you here: handsoff2025.com?SQF_SOURCE=s...

And don't forget to share your signs and tag us on socials!
#HandsOffOurScience @indivisible.org

05.04.2025 12:14 πŸ‘ 400 πŸ” 125 πŸ’¬ 8 πŸ“Œ 12

Awesome time in Virginia - grateful to my colleagues for the invite. What a great group here at UVA BIG center!

28.03.2025 03:45 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

We continue working on the plans for the "Woodstock of Bioloy 2 & Night science in Prague" meeting and if you don't sign up you're totally crazy. A once in a life time opportunity and it'll be sold out soon. Go to the website and sign up now before it's too late!

24.03.2025 04:44 πŸ‘ 41 πŸ” 16 πŸ’¬ 0 πŸ“Œ 1
graph of NIH basisfor new drugs

graph of NIH basisfor new drugs

A pie graph worth keeping in mind as the NIH budget plummets jamanetwork.com/journals/jam... for 356 new FDA drugs approved

23.03.2025 16:17 πŸ‘ 4029 πŸ” 1647 πŸ’¬ 60 πŸ“Œ 85

No, Mr. President, you cannot illegally arrest and detain legal US residents because of their political views or opinions.

In America, we have a little something called the First Amendment.

Throwing protesters in jail is yet another step on the path to authoritarianism.

12.03.2025 19:46 πŸ‘ 12922 πŸ” 2524 πŸ’¬ 387 πŸ“Œ 98
Preview
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.

New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024.

That's not to mention the countless lives that biomedical research has saved.

Show me a better investment than that.
www.forbes.com/sites/michae...

12.03.2025 20:47 πŸ‘ 2029 πŸ” 1143 πŸ’¬ 23 πŸ“Œ 71
Post image

On March 7th we will Stand Up For Science! You can use the link to find the protest location in your city.

standupforscience2025.org

23.02.2025 14:43 πŸ‘ 8 πŸ” 4 πŸ’¬ 0 πŸ“Œ 0
Post image

Welcome immigrants from X interested in science to the friendlier skies of @bsky.app, as documented by a new @nature.com survey (but you already knew that πŸ˜‰)
"Bluesky is much better for science. There is much less toxicity, misinformation, and distractions."
www.nature.com/articles/d41...

24.01.2025 15:22 πŸ‘ 15469 πŸ” 2383 πŸ’¬ 242 πŸ“Œ 118
Preview
The controls that got out of control: How failed control experiments paved the way to transformative discoveries: EMBO reports: Vol 0, No 0 EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

Despair not (yet)
"If a control experiment fails, does that mean that the entire experiment is poorly designed and you must restart from scratch? Often, yesβ€” but not always. I present five examples where failed control experiments triggered entirely new fields of research."

27.01.2025 06:13 πŸ‘ 43 πŸ” 16 πŸ’¬ 1 πŸ“Œ 2
Preview
Join researchers across the country in fighting restrictions on the NIH Please click the link to complete this form.

Join researchers across the country in fighting restrictions on the NIH form.jotform.com/250226137228...

28.01.2025 10:44 πŸ‘ 9 πŸ” 4 πŸ’¬ 1 πŸ“Œ 0
Video thumbnail

It’s official: The Microbiology Society is on Bluesky!

08.01.2025 12:03 πŸ‘ 225 πŸ” 90 πŸ’¬ 6 πŸ“Œ 10
Preview
Genetic Analysis of a Sarcoma Accidentally Transplanted from a Patient to a Surgeon | NEJM Modern concepts of cancer immunology originated from the classic observations by Jensen, Loeb, Tyzzer, and Little in the early years of the 20th century of the rejection of transplanted allogeneic ...

Bizarre tumor immunology accident. Surgeon injures hand while resecting malignant histiocytoma and finds an inflamed mass at the site of prior injury. Tumor cells transplanted, patient & surgeon HLA mismatched causing intense yet insufficient host-vs-graft response: www.nejm.org/doi/full/10....

05.01.2025 18:15 πŸ‘ 79 πŸ” 14 πŸ’¬ 4 πŸ“Œ 11

Starting a new lab?! The most important factors for choosing the university/institute/company are: the colleagues, students & postdocs, the leadership, equipment, the lab space and start-up funds; IN THAT ORDER.

05.01.2025 22:34 πŸ‘ 48 πŸ” 8 πŸ’¬ 7 πŸ“Œ 0

Excited to join the rest of the Twitter exodus here on Bluesky!

01.01.2025 21:08 πŸ‘ 13 πŸ” 1 πŸ’¬ 2 πŸ“Œ 0