Oscar

Integrative multi-omics reveals PARP14 as a key IFNγ-regulated mediator of metastatic progression in Ewing sarcoma. Metastatic Ewing sarcoma (EwS) remains a major clinical challenge, highlighting the need to identify molecular drivers of disease dissemination. Through integrated transcriptomic, functional, and mech...

To end the year I’d like to share our last work, comments are welcome! www.biorxiv.org/content/10.6...

Just kicked off the #BarcelonaBioMed Conference “When Development Meets #Cancer-Origins, Models & Therapies in #ChildhoodCancer”

Excited to hear from an outstanding line-up of speakers!

Organized by #IRBBarcelona & @sjdhospitalbarcelona.org

With the support of Fundación @bbvaenespana.bsky.social

Indeed!

Very proud on our stellar Alina Ritter for her frist first-author paper:

Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances #chemotherapy efficacy in #Ewing #sarcoma

tinyurl.com/3kcs3bc9

@dkfz.bsky.social
@uniheidelberg.bsky.social
@nct-heidelberg.bsky.social

We’re happy 😄 to share our latest work in Cancer Discov @theaacr.bsky.social – we discover that PTEN UPD 🧬 in endothelial cells causes vascular malformations in PTEN Hamartoma Tumor Syndrome (PHTS), create a new mouse model 🐀 & test PI3K signaling inhibitors 💊.

aacrjournals.org/cancerdiscov...

Targeting replication stress in neuroblastoma by exploiting the synergistic potential of second generation RRM2 and CHK1 inhibitors Tumor cells often cope with elevated levels of replication stress (RS) causing increased dependency on ATR-CHK1 signalling. We previously presented RRM2, the regulatory component of the ribonucleotide...

Targeting replication stress in neuroblastoma by exploiting the synergistic potential of second generation RRM2 and CHK1 inhibitors

www.biorxiv.org/content/10.1...

idibell.cat/en/2025/01/n...

In #biotech #stocks news, Donald Trump’s return to the White House is already having a big impact at the $47.4 billion U.S. National Institutes of Health (NIH), with the new administration imposing a wide range of restrictions, including the abrupt cancellation of grant review panels.

FEBS Press Using a mouse model that recapitulates the spread of tumor cells within the body, we have profiled paired tumors and metastasis samples using a multiomics approach combining different layers of biolo....

doi.org/10.1002/1878... Happy to share our last work! Great effort by @marionachicon.bsky.social and great collaborations! #ewingsarcoma #metastasis #animalmodels #research

December is always a good month! We have new doctor in da house! #sarcoma #research Sara Sánchez-Serra 👏🏻👏🏻👏🏻 Very proud of her!

I'm really happy to post for the first time here the words written in an incoming e-mail I just got: Dear Dr. Martinez Tirado:
We are delighted to inform you that your manuscript....😃
#sarcoma #metastasis #mousemodel