We previously engineered Saccharomyces cerevisiae through CRISPR-Cas9 integration to produce Ply511, a bacteriophage endolysin active against L. monocytogenes, showing the potential of engineered yeast to produce endolysins for biocontrol. In this study, we extended this approach to the probiotic yeast S. boulardii and directly compared the two yeasts as secretion hosts for Ply511. Using a simulated human gastrointestinal environment, we evaluated their ability to retain endolysin activity and reduce L. monocytogenes levels.
New paper from the CEB- @uminho.bsky.social & APC
๐๐ฏ๐๐ฅ๐ฎ๐๐ญ๐ข๐จ๐ง ๐จ๐ ๐ญ๐ก๐ ๐๐๐ฅ๐ข๐ฏ๐๐ซ๐ฒ ๐จ๐ ๐๐ง ๐๐ง๐ญ๐ข-๐๐ข๐ฌ๐ญ๐๐ซ๐ข๐ ๐๐ง๐๐จ๐ฅ๐ฒ๐ฌ๐ข๐ง ๐ฏ๐ข๐ ๐๐๐๐๐๐-๐๐๐ฌ๐ ๐๐ง๐ ๐ข๐ง๐๐๐ซ๐๐ ๐ฉ๐ซ๐จ๐๐ข๐จ๐ญ๐ข๐ ๐บ๐๐๐๐๐๐๐๐๐๐๐๐ ๐๐๐๐๐๐๐
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Appl Microbiol Biotechnol buff.ly/pDDfR3f
#CRISPRCas9
@ellen-murr.bsky.social @rioscolombo.bsky.social @colinhillucc.bsky.social
03.03.2026 08:13
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๐ข Final reminder to apply for ISAPP 2026 in Tokyo, Japan!
Please ensure your abstract is submitted by midnight (GMT) tonight (Monday, 23 February 2026).
๐ www.isapp-sfa.com/tokyo-2026
23.02.2026 10:51
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Probiotic yeast Saccharomyces boulardii is gaining attention for its unique traits and engineering potential. Could it power the next generation of therapeutic probiotics? Learn more in our latest ISAPP-SFA blog๐ฌ @isappscience.bsky.social
๐ www.isapp-sfa.com/new-blog/202...
25.08.2025 12:44
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This year marked my first @isappscience.bsky.social annual meeting as part of the @isappsfa.bsky.social executive committee (Communications)
Brilliant science, thoughtful discussion, and great company throughout.
A huge thank you to my fellow committee members, Iโm already excited for next year!
๐ซถ๐ผ
23.07.2025 16:03
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SFA Talks from @Kristinacampbell, Sean Gibbons, and Howard Bauchner offered invaluable wisdom on science communication, career development, and strategies for publishing in high-impact journals! ๐ #ISAPP2025
16.07.2025 04:29
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Are you up to date on our SFA blogs?๐
Visit our website to check out a catalogue of great blog posts from "Confessions of a Final Year PhD student" to "Gastrointestinal Motility: The Dynamic Conductor of the Gut Ecosystem" ๐
Join the SFA at isapp-sfa.com/member-regis...
10.07.2025 16:02
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Networking at meetings can sometimes be an overwhelming task, but at ISAPP 2024 Caroline Dricot found connections over scientific discussions, a brewery tour, and even an impromptu Irish dance! ๐ค
Read about her experience in our latest blog๐
๐ www.isapp-sfa.com/new-blog/202...
10.03.2025 12:40
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โ ๏ธLast chance to apply!
Abstract submissions for the ISAPP-SFA annual meeting meeting close TODAY! ๐
Don't miss this amazing opportunity. Sign up for ISAPP-SFA membership and send in your abstract now! ๐
๐isapp-sfa.com/member-registration-2024
๐isapp-sfa.com/submit-abstract-banff-2025
24.01.2025 09:37
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This month's ISAPP-SFA blog post by Breanna Metras presents FoodSeq, a method for assessing diet diversity by analysing plant DNA in stool samples๐ชดRead the full blog to learn more!
๐ www.isapp-sfa.com/new-blog/202...
๐Register for the ISAPP-SFA here: www.isapp-sfa.com/member-regis...
16.12.2024 18:04
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Member registration 2025 โ ISAPP Students and Fellows Association
โจSFA Membershipโจ
To join/renew your membership, fill out our registration form (there's no fee to join).
isapp-sfa.com/member-regis...
SFA Membership allows you to connect with an amazing network of ECRs, keep up to date on SFA blogs & events and the opportunity to attend our annual meetings!๐
28.11.2024 11:28
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