J Magarian Blander

To those of you interested in #inflammation #resolution and #tumormicroenvironment. I recorded this-braving cold windy conditions- to catch your interest. Join us!
youtu.be/jxcpEc8I9Eo.
Hope it musters your interest!

@keystonesymposia.bsky.social
Conference Alert ⏰ 🔔:
vimeo.com/1136180246/1...

⏳ Deadline Jan. 14 (11:59 PM MST)! Submit abstracts/apply for scholarships for Tumor Microenvironment / Inflammation Resolution.

🔗 keysym.us/KSTumorMicro26
| keysym.us/KSInflammati...

@coussenslab.bsky.social @sandramcallister.bsky.social @laurakiessling.bsky.social @magarianblander.bsky.social

We’re glad you’re happy with it. See you in Galveston at the GRC on antigen presentation!

Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity - Nature Immunology Here the authors show DNGR-1 expressed by cDC1s promotes CD8⁺ T cell priming to cytoskeletal neoantigens from dying tumor cells, thereby shaping cancer immune visibility and tumor evolution through im...

@drjonlim.bsky.social & @reisesousalab.bsky.social show cDC1s & DNGR1 favor "tethered" neoantigens from F-actin proteins, trapping them in necrotic debris for better cross-presentation! Calls for prioritizing these neoantigens for cancer vaccine design #Immunotherapy www.nature.com/articles/s41...

Tethered neoantigens from the dead sculpt tumor fate - Nature Immunology New data show that DNGR-1 enables type 1 conventional dendritic cells to sculpt cancer immunoediting through selective cross-presentation of F-actin-tethered neoantigens, enriching tumors for immune-e...

Very grateful to Prof. Blander & Dr. Jha for a thoughtful @natimmunol.nature.com 𝘕𝘦𝘸𝘴 & 𝘝𝘪𝘦𝘸𝘴 piece on our work 🙏

📄 A clear & critical perspective that places our findings in the broader context of dendritic cell biology, cross-presentation, and tumour immunoediting.

@reisesousalab.bsky.social

Congratulations!!!!

Secret Santa with our incredible lab family; thoughtful gifts, fresh popcorn, homemade cookies, laughter, and holiday cheer. Wishing everyone a joyful season full of rest, peace, and time with loved ones. Happy Holidays!
#LabLife #SecretSanta #HappyHolidays

Congratulations!

Thrilled to announce that my postdoc, Chongbo (Bob) Yang, is a Crohn's & Colitis Foundation Research Fellows Awardee! Meticulous to the core, Bob turns "impossible" into "inevitable" breakthroughs. Bob investigates DC response to RIPK3-driven inflammatory cell death. @crohnscolitisfdn.bsky.social

Good news shouldn’t wait, but it’s been a hectic work-heavy summer. I am delighted and honored to be among the Kenneth Rainin Foundation 2025 Innovator Award Grantees. Thank you to @krfoundation.org for supporting our work.

krfoundation.org/news/health/...

krfoundation.org/our-work/hea...

Thrilled to see two of my former postdocs, @gaetanbarbet.bsky.social ‬⁩ and Johan Garaude, shining on the speaker list at the @frenchdcsociety.bsky.social Biennial Meeting, @pasteur.fr ! Proud of their amazing work and contributions to the field! #Dendriticcell #ProudMentor

Working with a great team to organize @keystonesymposia.bsky.social “Inflammation Resolution: Emerging Concepts, Mechanisms, and Disease Insights” in Whistler, May 17-20 2026. SAVE THE DATE. Join us! keysym.us/KSInflammati... #KSInflammation26 #inflammation #inflammationresolution #cancer

Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...

Also: Loving the collaboration between Johan Garaude @immunoconcept @inserm.fr and Leif Sander @sanderlab.bsky.social on this work. Johan and Leif met in my lab and have been friends and collaborators since (I’ll just say a while ago). Brings a smile to my face!
www.nature.com/articles/s41...

Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...

Thrilled for Johan Garaude’s @inserm.fr new work in Nature! I’m proud to see this Blander lab alumnus shine. His group shows bacterial cAMP accumulation signals death, fueling macrophage recycling—a fresh live-vs-dead immune twist. Stellar work with huge impact! www.nature.com/articles/s41...

Two modes of noncanonical NLRP3 inflammasome activation in response to distinct viability patterns of Gram-negative bacteria.

Vita-PAMP bacterial mRNA+LPS in sterile tissue = potentially dangerous live bacteria, & like virulence factors, activate the noncanonical NLRP3 inflammasome. Find out the common & distinct features of activating this pathway by a vita-PAMP vs virulence factor:
www.sciencedirect.com/science/arti...

Grateful to have our newly published work in Nature Immunology highlighted by @weillcornell.bsky.social. Honored to contribute to the amazing research happening here.
news.weill.cornell.edu/news/2025/01...
#Medicalresearch #cancer #immunology #inflammasome

Integrated oncogenic monitoring in premalignant tissue.

Macrophages help tumors grow, but what about early on when transformed cells first arise in tissue? Macrophages may collaborate with the cell-intrinsic barriers to transformation in a form of ‘oncogenic monitoring’. Curious? My hypothesis full text here till 2/15
authors.elsevier.com/a/1kKoc3OeyG...

A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis - Nature Immunology Blander and colleagues report a homeostatic regulatory effect played by inflammasomes in the bone marrow stromal compartment that suppresses premalignant stages of lymphomagenesis.

Ever wonder if the innate immune system protects against cancer in premalignancy? My lab reports that the inflammasome in bone marrow stroma suppresses Ras in preleukemic stem cells restraining lymphomagenesis.

Happy to share here: www.nature.com/articles/s41...