Our new study is out in Nature Communications.
Using TNBC organoid mouse models, we show that necroptosis in both tumour and stromal compartments cooperatively drives effective responses to immunogenic cell deathβbased immunotherapy.
π www.nature.com/articles/s41...
There are no vaccines to prevent alpha-gal syndrome currently.
Researchers are also exploring broader strategies i.e
vaccines targeting tick saliva proteins that could potentially block transmission of multiple tick-borne pathogens at once.
www.globallymealliance.org/news/a-lab-s...
Here is the "effective payline" for each institute, estimated (by Claude) as the percentile where one can expect 80% probability of funding from a logistic regression fit. The effective payline has gone from a historic ~12% to 6% in 2025.
Graph of award probability of R35 and R01 from NIH factbook as a function of review rank percentile. As is apparent, 2025 is a significant departure, with lower award probabilities at all scores <40 and significant departures from norm, where even being in the top 10% is no longer a nearly certain indicator of success. Data source: https://report.nih.gov/nihdatabook/report/302
The data is in: the NIH goalposts have shifted.
What were once almost certain fundable scores have become coin flips and what used to be likely grants have become aspirational, leading to fewer awards.
Another manifestation of how HHS policies have led to fewer awards and less science.
It's hard to imagine having him as a colleague, even before his stint in the Trump administration.
Definitely a spring peeper and right on time, especially with the recent warm weather. They are among the earliest to be out calling.
Maybe Sheehy should go back to war, he seems to enjoy harming people.
Job opening: Professorship for Molecular Pharmacology at Marburg University, Germany.
We seek a scientifically outstanding researcher in the field of epithelial biology in inflammation, regeneration, and/or cancer.
stellenangebote.uni-marburg.de/jobposting/0...
The wonderful historic city of Marburg
π¨ University Marburg (Germany) is recruiting a W2 Professor of Mol. Pharmacology in the Faculty of Medicine.
Focus areas: Epithelial adaptation in #inflammation, #regeneration, and/or #cancer
stellenangebote.uni-marburg.de/jobposting/0...
#AcademicJobs #Pharmacology #FacultyPosition #cellbio
VΞ³1 Ξ³Ξ΄ T cells steer airway macrophages toward a profibrotic response in an autochthonous lung cancer mouse model
#gdTcells @coffeltlab.bsky.social
Excited to collaborate with @hassansalem.bsky.social and @tatsuyanobori.bsky.social on this new Postdoc opportunity!
If you're interested in the developmental biology of symbiosis, apply and join us @johninnescentre.bsky.social and @thesainsburylab.bsky.social πͺ²π¦ π¬
Played a small part in this cool study @jem.org.
Identifies myofibroblasts as sources of tissue damaging enzymes (MMP1) in TB granuloma, probably responding to cytokine cues from nearby macrophages.
Question now is: can we target therapeutically to prevent post-TB lung damage?
#TBSky #IDSky
Excited to announce the opening of the applications for the Master in Biomedical Research.
An international, hands-on programme for students to think like scientists, work in real labs, and prepare for PhD training or R&D careers, in Lisbon. GIMM Institute
1/3
With this war on Iran costing $1B per day, we are now at 4$B, an amount that would fund 3,200 five year NIH biomedical research grants.
Activin A secretion by muscle-repairing macrophages induces heterotopic ossification in mice @jci.org
www.jci.org/articles/vie...
Secretary Marco Rubio claimed no one died as a result of cuts to USAID. Thatβs not what we found.
After Trump officials cut food aid to Kenya, children starved to death in an American-made hunger crisis.
(Published Dec. 2025)
They chose Trypanosoma crassii specifically because:
1) it's related to two human parasites - T. brucei (sleeping sickness) and T. cruzi (Chaga disease).
2) Because it can infect zebra fish larvae, its behaviour can be observed in situ through the fish's body π§ͺ
pmc.ncbi.nlm.nih.gov/articles/PMC...
One of my favourite papers about Trypanosoma parasites is this study where researchers infect zebra fish larvae (which are transparent) with Trypanosoma carassii and were able to observe how these single-celled parasites move through their host's body. π§ͺ
pmc.ncbi.nlm.nih.gov/articles/PMC...
Dunkleosteus terrelli (Newberry, 1873) - fossil fish skull (real) from the Devonian of Ohio, USA. (public display, Cleveland Museum of Natural History, Cleveland, Ohio, USA) The placoderms are a group of extinct, mostly predatory fish that existed during the Middle Paleozoic (Silurian and Devonian). The most famous placoderm was Dunkleosteus, which was named after David Dunkle, an Ohio paleontologist. It was not a shark - it had a bony skull, a neck joint, and remarkably, the jaws lacked true teeth. Instead, the jawbones were sharp-edged and pointed. https://commons.wikimedia.org/wiki/File:Dunkleosteus_terrelli_(fossil_fish)_(Cleveland_Shale_Member,_Ohio_Shale,_Upper_Devonian;_Rocky_River_Valley,_Cleveland,_Ohio,_USA)_21_(34001200911).jpg
The Late Devonian (~380 MYA) was an era dominated by armored fish like Dunkleosteus terrelli here. They were primarily cartilaginous, like the sharks they hunted, but covered by armor plates up to 3 in. (7.6 cm) thick.
They were also among the first animals to give live birth.
Prolonged dysregulation and pathological changes in the upper respiratory tract of SARS-CoV-2 infected hamsters
www.nature.com/articles/s44...
The Voyageurs Wolf Project of Northern Minnesota tags & documents grey wolf ecology & behavior: www.voyageurswolfproject.org
The video you see here is confirmatory proof:
Wolves. Love. Blueberries.
As much as 83% of a wolf's calories in summer months comes from eating berries.
That's right. Worse than Pointless
www.nytimes.com/2026/02/23/o...
People seem to forget this is how it starts, not how it ends. There's a lot that happens and, as history notes, oftentimes goes sideways between here and there.
The first concern with measles is, of course, the devastating health impact.
But this article does a great job of explaining the economic costs.
ππβMonochromatic seagrass meadowsβ¦are havens for fish, protect coasts from storms and are key stores of carbon, making them some of the worldβs most valuable natural spaces.Despite their importance, these ecosystems are in dangerβ¦an estimated 7 per cent of meadows are being lost worldwide per year.β
Poster of the 2026 CSHA meeting on Bacterial Infection & Host Defense.
Please join us for the Cold Spring Harbor Asia @cshlnews.bsky.social meeting on Bacterial Infection & Host Defense this May 11-15 in Suzhou, China! We have a fantastic lineup of speakers. Abstract deadline is March 6. Hope to see you there!
White House stalls release of approved US science budgets: The administration has not yet released funding Congress allocated to multiple research agencies, so they cannot provide it to funded entities/people - including NIH and NASA. www.nature.com/articles/d41...
Absolutely agree. I hate Doodle polls so much.
It's a litany of lines borrowed verbatim from other speeches that he's repeated ad nauseum over the last year.
Okay, folks- I know we all have plenty to do, but if you're at all concerned about the White House & historic preservation, please consider submitting public comment on Trump's ballroom project; info in this thread. First, a direct link for submitting written statements: www.ncpc.gov/participate/...
