Pedro Torres-Ayuso

Today is #InternationalDayofWomenandGirlsinScience. Through grants, education and training, and our Women in Cancer Research constituency group, the AACR is committed to inspiring and advancing #WomenInScience. buff.ly/OXy6wnS

Congrats, Trudy, Luke, Tony and team! Beautiful work!

KLF4 promotes a KRT13+ hillock-like state in squamous lung cancer - PubMed Lung squamous cell carcinoma (LUSC) is basal-like subtype of lung cancer with limited treatment options. While prior studies have identified tumor-propagating cell states in squamous tumors, the broader landscape of intra-tumoral heterogeneity within LUSC remains poorly understood. Here, we employ S …

Transcriptional plasticity is a major barrier to effective cancer treatment. We know a lot about it in #SCLC but less is known for #squamous #lungcancer. Luke Izzo & Tony Reyes have made major inroads into this problem in our latest preprint:
pubmed.ncbi.nlm.nih.gov/40161723/

Outstanding Research Opportunity in Cancer-Focused Bioinformatics and Computational Biology - Philadelphia, Pennsylvania (US) job with Temple University | 12852645 Outstanding Research Opportunity in Cancer-Focused Bioinformatics and Computational Biology at the Lewis Katz School of Medicine at Temple Universi...

Our department is hiring!!! If you have research interests in cancer-focused bioinformatics and computational biology, apply to join us in the Department of Cancer & Cellular Biology at Temple University Lewis Katz School of Medicine👇

Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer Nature - Basal cells, rather than neuroendocrine cells, have been identified as the probable origin of small cell lung cancer and other neuroendocrine–tuft cancers, explaining...

Super pleased to announce our latest suggesting the cell of origin for #SCLC is most likely the basal cell @nature.com, not the accepted neuroendocrine cell. Implications for the earliest events in cancer, & providing new models of tuft-like cancer.
rdcu.be/eGUtj

Excited about my first PhD Poster Presentation at Dawn Marks Research Day 2025! Shared research on mitochondrial metabolism in squamous cancers. Big thanks to everyone for their insights and to my mentor @ptorresayuso.bsky.social. Looking forward to more learning and networking! #KatzTempleMed

I am so lucky to count with the amazing #oneandonly @rolanddunbrack.bsky.social as my colleague and thrilled to count him as my dear friend!!!
#congratulations!!!

FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma By transcriptomic analysis, Lubrano et al. demonstrate that FAK-regulated pathways are enriched in BRAFi+MEKi-resistant melanoma lesions. In BRAF V600E melanomas, MAPK inhibition decreases RhoE (RND3) expression, activating the RhoA-FAK-AKT pathway and…

Online now: Online Now: FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma

Un estudio del IRB revela por qué las mismas mutaciones producen leucemias muy diferentes El estado previo de las células madre influye de forma “decisiva” BARCELONA, 25 (EUROPA PRESS) Un estudio del Instituto de Investigación Biomédica (IRB) de Barcelona ha r...

🧪Un estudio del @irbbarcelona.org revela por qué las mismas mutaciones producen leucemias muy diferentes.

🗞️ @lavanguardia.com

➡️ shorturl.at/hDINa

#CancerResearch #Leukaemia #Leucemia @alejofraticelli.bsky.social

Hi greater Philly area folks, here's the link to the local site for this action. It will be 3/7 at 11am at City Hall. An important opportunity to make it clear that science in the US as we know it is in danger! Science is for everyone and benefits everyone. standupforscience2025.org/philadelphia...

Welcome to the Bluesky account for Stand Up for Science 2025!

Keep an eye on this space for updates, event information, and ways to get involved. We can't wait to see everyone #standupforscience2025 on March 7th, both in DC and locations nationwide!

#scienceforall #sciencenotsilence

STAND UP FOR SCIENCE March 7, 2025. Washington DC and Nationwide. Because Science is for everyone.

The Stand Up For Science website has been updated. Find your local protest site! March 7! Get out there!

standupforscience2025.org

President Trump's NIH cuts will damage our health, our research, and our global leadership.

Thanks to my 149 House Democratic colleagues who joined @amo.house.gov, @degette.house.gov, @replindasanchez.bsky.social, and me in making the case to rescind harmful NIH cuts.

🧬 Happy International Day of Women and Girls in Science! 🧬

Today we celebrate metastasis research leaders:

🔬 Dr. Alana Welm @alanawelm.bsky.social, MRS President.

🔬 Dr. Neta Erez @netaerez.bsky.social, incoming President.

Inspiring the future! 💪✨ #WomenInScience #IDWGS #MetastasisResearch

AACR Legislative Action Center Directly contact your elected officials about the importance of cancer research, the need for continued funding and the latest lifesaving breakthroughs. In the United States, you can do so by sending ...

Kudos to the @theaacr.bsky.social for making it easy to reach out to your representatives. Nice to see courage and action. nam02.safelinks.protection.outlook.com?url=https%3A...

The AACR is deeply concerned that the Administration’s recent actions are threatening NIH and its mission to accelerate progress for patients with cancer and other diseases that afflict millions of Americans. Read our statement: https://buff.ly/4gRXNB8

AACR urges Congress to reaffirm its long history of steadfast and bipartisan support for medical research by ensuring that NIH has all of the resources needed to advance its lifesaving mission to prevent, diagnose, and treat cancer and other diseases: AACR.org/NIH

🧪Researchers at @irbbarcelona.org and the @upf.edu unravel peroxiredoxinylation, a type of post-translational modification.

✍️ Gerhard Seisenbacher, @laia-de-nadal.bsky.social, Francesc Posas, et al.

📰 Cell Reports

➡️ bit.ly/4k53Hlq

📌DOI: 10.1016/j.celrep.2024.115224

#IRBScience #ChemBio

This week we had International Day of Women and Girls in Science 👩‍🔬 🥼 🔬

There are many women working to provided the resources at PDBe, AlphaFoldDB, EMDB and EMPIAR. Lets met a few of them!

#IDWGS #WomeninSTEM #WomenInScience #WhatAScientistLooksLike

Postdoctoral Fellow - Philadelphia, Pennsylvania (US) job with Temple University School of Medicine | 12836829 Postdoctoral fellow within the Aging + Cardiovascular Discovery Center at Temple University

My lab is looking for an enthusiastic postdoc interested in studying lysosomal signaling dynamics in cardiac health and disease. Those especially interested in development & use of targeted biosensors and dynamic super-resolution imaging are encouraged to apply. www.nature.com/naturecareer...

NIH slashes overhead payments for research, sparking outrage and lawsuit Move to cut indirect cost rate to 15% could cost universities billions of dollars

Breaking news: 22 states are suing to block NIH’s cutting of indirect costs.

See our updated story on the Friday night news and its aftermath. scim.ag/4hTJQ6v

The NIH’s drastic cut to indirect cost rates is a critical threat to U.S. research infrastructure The drastic reduction in indirect costs is not a path to innovation or cost savings — it’s a threat to U.S.’s position as global leader in medical research.

My #Yale colleague Harlan Krumholz explains why the cuts to indirect costs are a disaster for biomedical research in the United States. Want to do something about it? I'll list those who have to hear from us below. Share, recruit friends and family to help. 1/ www.statnews.com/2025/02/08/n....

1. Today the NIH director issued a new directive slashing overhead rates to 15%.

I want to provide some context on what that means and why it matters.

grants.nih.gov/grants/guide...

I wrote this just two weeks ago - could not have imagined how broadly #science and #researchers in the US have been impacted since then



Science is a #global community 🌍 🌎 🌏

We're all very concerned for our friends, colleagues, and young researchers in the US right now



#solidarityforscience 🧪

Trump's Assault on NIH Will Kill People With Cancer Splinter is your home for news and opinions that challenge power in our political and economic system that's becoming more unhinged each and every day.

Here's what I've heard so far from inside the National Cancer Institute as well as other NIH institutes.

Trump Is Trying to Destroy Public Health in America The administration has forced crucial scientific activity to grind to a halt. It’s an act of national suicide.

'Most Americans probably don’t know this, but so much of what we take for granted when we seek care in the US—the medicines, the diagnostics, the procedures—have come out of NIH research.'
@gregggonsalves.bsky.social
www.thenation.com/article/soci...