Manav Pathania

a close up of a feather on a rock with the words `` hello '' written in white letters . ALT: a close up of a feather on a rock with the words `` hello '' written in white letters .

We're seeking to fill two roles: a postdoc and a research assistant. Both will focus on resistance mechanisms in brain tumour models using various approaches (in vivo, spatial omics, CRISPR). Please apply if this aligns with your previous experience!

shorturl.at/hZ6mG

The reforms to UKRI under Ian Chapman are only just starting, but there are already worries about what they mean for the bread and butter, applicant-led funding calls at research councils

While UKRI insists comparisons with previous years are impossible, figures from December suggest...

a penguin wearing a red bandana and a tie looks through binoculars Alt: a penguin wearing a red bandana and a tie looks through binoculars

Please share or forward to anyone interested in joining our lab as a research assistant, details can be found via the link below

shorturl.at/x0cSs

a woman in a yellow wig and white sunglasses ALT: a woman in a yellow wig and white sunglasses

Please share or forward to anyone interested in joining our lab for a postdoc, details can be found via the link below

shorturl.at/GMbW0

Thanks Vincenzo!

Thanks to all those who helped us get going in Cambridge and looking forward to getting stuck in at Oxford soon!

Ludwig Oxford welcomes Dr Manav Pathania Ludwig Oxford is delighted to welcome Dr Manav Pathania as an Assistant Member of the Ludwig Institute for Cancer Research, Oxford Branch.

The Pathania lab will be moving to the Ludwig Institute in Oxford in early 2026. We'll be recruiting postdocs and research assistants soon, so keep an eye out for those job ads and reach out if you want to find out more about the science we have planned!

shorturl.at/thpyK

FlyBase secures funding for year, but future still uncertain The FlyBase team’s fundraising efforts have proven successful in the short term, but restoration of its federal grant remains uncertain.

🪰 folks! I spoke to the Transmitter about FlyBase. As noted at flybase.org, bridge $ ran out and many staff were laid off.

Good news is stopgap contributions will keep core FlyBase operations active. But community support remains essential. Please donate @FlyBase and share! 1/2

tinyurl.com/FlyBase

amzn.eu/d/1UfEI6m there's also this one

Hope you like it! There's a huge range of daals, making use of many varieties of legumes and lentils. I could live on just daal and rice!

amzn.eu/d/8u6HmsM

Yes, it was carefully hidden in the New England Journal of Medicine.

Pfizer/BioNTech vaccine (www.nejm.org/doi/pdf/10.1... )

1/2

Congrats to everyone involved!

When mRNA vaccines are wrongly attacked, this is one of many examples of what you're missing.
A broad spectrum prevention strategy against viruses
www.science.org/doi/10.1126/...

Pathania lab team members sitting at a desk waiting for prosecco and some cake to be served up

Farewell for Carmo, RA extraordinaire! Good luck in your PhD at the Crick and thanks for all your hard work over the last 3 years!

High-speed mapping of whole-mouse peripheral nerves at subcellular resolution A high-speed pipeline enables whole-mouse imaging and mesoscopic analysis of peripheral nerves using transgenic, immunostaining, and viral labeling, providing an effective means to map body-wide struc...

WOW!!!!!😱😮

High-speed mapping of whole-mouse peripheral nerves at subcellular resolution: Cell www.cell.com/cell/fulltex...

Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer’s disease - Nature Medicine Spatial transcriptomics reveals distinct microglial mechanisms driving amyloid-β clearance in both passively and actively immunized patients with Alzheimer’s disease.

A study in Nature Medicine shows the mechanisms driving amyloid-β clearance in both passively and actively Aβ immunized patients with Alzheimer’s disease. #alzsky 🧪

Modification of the telomerase gene with human regulatory sequences resets mouse telomeres to human length - Nature Communications Mice models often fail to reflect human telomere biology. Here, the authors engineer a mouse strain with a humanized mTert gene, restoring telomere length regulation to a human-like pattern. This mode...

Modification of the telomerase gene with human regulatory sequences resets mouse telomeres to human length

👉 These mice, with humanized telomere regulation, represent a valuable model to study human aging and cancer.

www.nature.com/articles/s41...

From a journalist friend: Just spreading the word. The CDC is purging data, so people should archive their favorite CDC datasets today, namely ones around race/ethnic diversity, LGBTQ, and reproductive health. Also health data involving climate. The youth risk behavior survey has already gone down.

Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding Glioblastoma is a highly aggressive primary brain tumor with glioblastoma stem cells (GSCs) enforcing the intra-tumoral hierarchy. Plasma cells (PCs) …

Infiltrating plasma cells maintain glioblastoma stem cells through IgG-Tumor binding

www.sciencedirect.com/science/arti...

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Buon Anno!!

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Merry Christmas!

Holiday lunch with the lab at The Graduate Cambridge photo 1

Holiday lunch with the lab at The Graduate Cambridge photo 2

Rounding out the year with the team

Regulation of human interferon signaling by transposon exonization Transposable element exonization can yield functional protein isoforms as seen for primate-specific IFNAR2.

I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪

Our Paper out in @natureportfolio.bsky.social with correct link www.nature.com/articles/s41...

Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma - Nature The prodrug gliocidin effectively kills glioblastoma cells by targeting de novo purine synthesis, improving survival in mouse models.

Gliocidin is a nicotinamide-mimetic prodrug that targets glioblastoma
www.nature.com/articles/s41...

Hi, please could I be added?

Happy International Day of LGBQTIA+ People in STEM! Proud to advocate for the enriching benefits of diversity, of experiences and viewpoints, IRL and on this platform.

A Compendium of Syngeneic, Transplantable Pediatric High-Grade Glioma Models Reveals Subtype-Specific Therapeutic Vulnerabilities Models of pediatric high-grade glioma reveal genotype–phenotype associations, differences in cell type composition, and sensitivity to targeted and combination therapy approaches, making preclinical e...

Hi Bluesky! I am a PI in the Dept of Oncology at the University of Cambridge, UK. Our lab develops mouse models of different types of brain tumours and uses these to explore targeted treatments, TME interactions, and the role of heterogeneity in resistance.
doi.org/10.1158/2159...

Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas

Incredible study now out in Nature, with long-term remission for pediatric glioma

Michelle Monje, Crystal Mackall et al

Well done to all the authors for this true tour de force!
🧪⚕️🩺

www.nature.com/articles/s41...