📢 We are hiring a bioinformatician!
📍 @gustaveroussy.fr - U981
⏳ 18 months contract
📩 hire.u981.hemonc@gmail.com
Thanks for reposting
#Recruitment #Genomics #Bioinformatics 👇
@weillcornell.bsky.social newsroom coverage here meyercancer.weill.cornell.edu/news/2025-12...
Our study with @melnicklab on the discovery of a transient and tightly-regulated, plastic state of mature B cells during physiological immune response and potential links to aggressive lymphomas now out at NCB.👇Detailed threat by the amazing lead author @lscourzic.bsky.social!.
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Massive effort from the 4D Nucleome consortium and excellent resource for the community! Don’t miss it!
Our study with @stadtfeldlab.bsky.social on the dual mechanism by which EHMT2 is repressing totipotency-associated vs lineage-specific loci is now out @emboreports.org. See thread by @cmuyehara.bsky.social who led the study with K Chatterjee. Full article here link.springer.com/article/10.1...
Don't miss the chance to attend the annual virtual meeting on the advances in Nuclear Topology and 3D chromatin Architecture in Cancer organized by @janeskok @iannisaifantis1 @artsinyc and Melnick. The registration is FREE (see barcode) and the speaker lineup SPECTACULAR.
Amazing news KJ!!! Very well deserved! Congratulations!!!🎉 🎉🎉
Don't forget to register for the upcoming Keystone Symposium Epigenetics & Gene Regulation in Health and Disease (Geveva, March 03-06). Join us for fun discussions on chromatin mechanisms and therapeutic innovation! keysym.us/KSEpigenetic...
Congratulations Christa!!! Wishing you many productive and fun lab decades ahead! That seems delicious!!!
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Honored and excited to be among the speakers in the upcoming #KSEpigenetics26 symposium! Thank you @kjarmache.bsky.social and @ckadoch.bsky.social for the invitation. Follow the link to register 👇👇👇
Fraud, using A.I., impersonating medical professionals
Front page NY Times
www.nytimes.com/2025/09/05/t...
Honored to be part of the "Reprogramming Stars" interview series by @cellreprolab.bsky.social @CellularReprogramming. Humbling title but very fun discussion about past and ongoing research, future directions, advice to new trainees and more. Check it out! www.liebertpub.com/doi/10.1177/...
Another Exciting Fusion conference on 3D genome organization is coming up! #SGO25! Deadline for registration on September 1st! Hope to see many of you there!
NEW
The White House is blocking the NIH from awarding new research grants for the rest of the fiscal year
Chokes off billions in research funding
Gift link www.wsj.com/politics/pol... with @nidhisubs.bsky.social
The proposed budget slashes NIH by ~40%, devastating medical research, clinical trials, treatment breakthroughs—life-saving work.
Thousands of lives at risk for tax cuts for the rich? NO THANKS.
Tell your senators to oppose the cuts HERE:
zurl.co/qiKdX
zurl.co/RCR0y
#CutsCostLives
Check out this new preprint with @distefanolab.bsky.social lab! The manuscript focuses on RNA processing in the form of sequestration into P-bodies in the context of development.
I am looking for postdocs to join my group at NIH. Are you interested in Development, Evolution, Genetics, Genomics, and Human health? Please apply! www.training.nih.gov/jobs/pdf-mb-...
A few days left to apply for exciting PhD and Postdoc opportunities in wonderful Copenhagen and join our efforts in understanding Epigenetic Cell Memory.
That’s huge!!! Congratulations Bing and welcome to NYC!!!
Congratulations to @SarahBreves, @dafnecdg.bsky.social and Alex Polyzos for driving this study and many thanks to the Fine group and all collaborators for their critical contributions!!! Grateful also to Howard Chang for sharing their data.
What drives 3D hub formation? Intriguingly, only a small fraction of 3D hubs overlapped with predicted structural variants, such as amplifications, suggesting epigenetic mechanisms. Transcription factors with enriched binding on hubs were often predictive of worse outcomes.
What about other cancers? Using published HiChIP datasets across 16 cancer types we also identified shared and tumor-specific 3D hubs associated with universal or cancer-specific oncogenic programs.
CRISPRi targeting of a highly recurrent hub -with previously unknown role in GBM- was sufficient to cause concordant downregulation of multiple hub-connected genes, global transcriptional shifts and reduced clonogenicity.
Moreover, gene pairs within hubs showed significantly higher coregulation in single-cells compared to genes within the same TAD or in proximity. However, for hubs connected to multiple genes the mean coregulation is highly variable likely reflecting intratumoral heterogeneity.
By mapping 3D enhancer-promoter networks in patient-derived glioblastoma stem cells, we identified hyperconnected 3D hubs that strongly enriched for universal and tumor-specific programs and accurately distinguished aggressive IDH-wt from lower-grade glioma patients.
The first cancer-related story from our group @WeillCornell
is now published in @MolecularCell. We investigate the role of hyperconnected 3D regulatory hubs in controlling oncogenic programs and properties in glioblastoma and also across 16 cancer types. www.cell.com/molecular-ce...
