Out today: We discovered new viral proteins that target immune signaling molecules, solely based on their AlphaFold-predicted shapes
www.science.org/doi/10.1126/...
Congrats Nitzan Tal and coauthors! Thank you Kranzusch lab for the fun collaboration!
Linking below previous thread on our findings
I’m sick just thinking about it
the web is a customer service medium, thats why its so unpleasant imo
like trying to have a good time with the other people in line to return a defective vacuum and a yeti rambler to target
Why would I try
Everybody thinks that everybody else understands linear algebra better than they do
Ime anything that starts with “undergraduate linear algebra tells you” and ends with something people care about should be a paper. Linear algebra is where the Common Knowledge caps out currently
[channeling cosma] most priors are smoothing
They will give Kaitlin computer 😈
It’s rumored that I am in NYC
Ayatollah Ali Khamenei, the supreme leader of Iran, was killed Saturday after the US and Israel launched airstrikes on Iran, according to President Donald Trump. He was 86.
So proud of this work with @rolanddunbrack.bsky.social! Did a lot of new structural bioinformatics of substrate-bound kinases and came up with updated criteria for classifying structures as active. Also made active models of all 437 human catalytic kinases, available here: dunbrack.fccc.edu/kincore
Great work from post-doctoral fellow @joanzone.bsky.social:
New preprint on identifying active structures of protein kinases -- capable of binding ATP, Mg ions & especially substrates -- +modeling all 437 human catalytic protein kinase domains in their active conformation.
doi.org/10.64898/202...
Broke: dead internet theory
Woke: undead internet theory
REAL
I’m always saying this
A friend has managed to host a weekly watch party that has thus far made it all the way through “the evil that men do”
I’d love to read this. Would you be willing to email me a PDF? I can provide my email over DM
hi guys I know I haven't been very active lately, and I don't talk about where I'm from often, but the government made some really scary announcements today so I thought I'd share to let everyone know what's happening. here are some posts from twt for context
Our paper is now out in Nature:
“Ancient co-option of LTR retrotransposons as yeast centromeres”
www.nature.com/articles/s41...
A short thread on how retrotransposons helped give rise to yeast point centromeres.
1/14
wtf I did NOT know this
I have yet to see anything more impressive than those side projects programmers used to show off on hackernews but maybe I’m not looking in the right places.
do I have any followers in Canada (Toronto, Ottawa, Montreal) who are academics and think they have anything academic overlap with what I do (complexity and predictive modeling, information theory)? I'm planning a Canada tour and am interested in hitting as many academic centers as possible
endometriosis
What’s the most impressive piece of AI-coded software you’ve seen? Bonus points for comp biophys
theres kind of a fun read of this to do where its about the cost of signifiers: a lot of peoples' wages went down in terms of F-250s
How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller?
Excited to share our latest work in @science.org on a new small polymerase.
1/n
kresten is cooking this year
best halftime show ever
“im not familiar with bad bunny but..” i mourn for the lack of baddies in your life brother
