Milo B. Fasken, Ph.D.

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Composite SMG5-SMG6 PIN domain formation is essential for NMD - Nature Communications Execution of mRNA cleavage in nonsense-mediated decay remained elusive. The authors show that SMG5 complements SMG6 to form a highly active, composite endonuclease with expanded catalytic center that ...

www.nature.com/articles/s41...

#RNASky #RNAbiology

How the TREX-2 complex associates with the nuclear pore www.biorxiv.org/content/10.6...

#RNAsky 🤩🤩🤩🤩🤩🤩🤩

Nice review! 😊
#RBP #RNA

Mechanistic insights into recruitment and regulation of the RNA helicase UPF1 in replication-dependent histone mRNA decay - Nature Communications Replication-dependent histone mRNA decay involves the RNA helicase UPF1, the histone stem-loop binding protein SLBP and the exoribonuclease 3’hExo. Here, the authors present evidence for assembly of a...

What’s #UPF1

www.nature.com/articles/s41...

Happy New Year! Wishing everybody some “Good Science” for 2026! 🧬😊

The RNA exosome maintains cellular RNA homeostasis by controlling transcript abundance in the brain Higginson et al. present a cell-type-resolved atlas of RNA exosome dysfunction in the Drosophila brain, showing that pathogenic Rrp40 mutations disrupt RNA surveillance and neuronal integrity. This re...

Exollent! Congrats!
#RNAExosome #RNA

www.cell.com/cell-reports...

Happy Holidays!

Targeted RNA-binding protein degradation to improve mRNA live imaging in animal cells - Nature Methods The gold standard system for mRNA imaging in live cells just got upgraded by being degraded. This development improves signal-to-noise ratios and may lead to a better understanding of mRNA transport a...

My "News & views" was published today @natmethods.nature.com

Thanks @ritastrack.bsky.social for the invitation to write it and Allison Doerr for the editing after Rita left...

www.nature.com/articles/s41...

December 10: NCI RNA Biology Initiative & Penn Institute for RNA Innovation YouTube video by RNA Collaborative Seminar Series

My talk from the latest RNA Collaborative Seminar Series is now available on YouTube. The second talk in the session was given by Rachel Braun (Sara Cherry’s lab) on TTP and its role in regulating antiviral immunity. youtu.be/2Aj-xbi3dPI #RNAsky #RNAbiology

Hey Bud!
#BuddingYeast

Nuclear exosome targeting complex safeguards hematopoietic stem cell self-renewal and genomic integrity through resolving R loops R loops form during transcription, threatening the genomic stability of hematopoietic stem cells (HSCs) and lymphoma cells. Pan et al. report that ZCCHC8 safeguards the genome integrity and self-renew...

#NEXT story to read! Cheers!
#RNAExosome
www.cell.com/cell-reports...

The complex life of RNA

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Why Does A.I. Write Like … That?

Why Does A.I. Write Like … That? www.nytimes.com/2025/12/03/m...

Gene regulation through exon junction complex modularity - Nature Structural & Molecular Biology This Review summarizes the various functions of the exon junction complex in RNA splicing and beyond, to influence gene regulation.

Nice Review #EJC

www.nature.com/articles/s41...

Nuclear effects play an important role in determining codon usage-dependent human gene expression - Nature Communications Codon usage influences gene expression by affecting how efficiently genes are read and processed. Here, the authors identify nuclear factors, including CNOT4, the RNA exosome, and the PAXT complex, th...

www.nature.com/articles/s41...

Transcriptome-wide mRNP condensation precedes stress granule formation and excludes new mRNAs Glauninger, Bard, Wong Hickernell, et al. reveal that stress causes transcriptome-wide mRNP condensation, largely independent of length and often without stress granule formation, but newly synthesize...

Nice work!
#mRNP #Condensation #Stress #Yeast
Transcriptome-wide mRNP condensation precedes stress granule formation and excludes new mRNAs: Molecular Cell www.cell.com/molecular-ce...

Timing of transcription controls the selective translation of newly synthesized mRNAs during acute environmental stress Under stress, cells adapt their gene expression programs through changes in transcription and translation. It is unclear how cells determine which mRNAs are translated or repressed. Zedan et al. show ...

Nice work!
#mRNP #Condensation #Stress #Yeast
Timing of transcription controls the selective translation of newly synthesized mRNAs during acute environmental stress: Molecular Cell www.cell.com/molecular-ce...

DIS3 licenses B cells for plasma cell differentiation in humans - Cellular & Molecular Immunology Cellular & Molecular Immunology - DIS3 licenses B cells for plasma cell differentiation in humans

Look at DIS! #DIS3 #RNAExosome #PlasmaCells

www.nature.com/articles/s41...

I wanted to say thanks for your paper as well and congrats to your student! Wonderfully thorough and mechanistic story. It brought me great joy to see evidence that Nrd1 could bind to a mRNA independent of Nab3 in vivo. The phenotypic consequences of mutating Nab3 binding sites on PIC2 are amazing!😊

A transcription termination mechanism for maintaining homogeneous protein expression Abstract. Premature transcription termination is a critical mechanism for repressing harmful, unproductive transcription. In Saccharomyces cerevisiae, prem

Nice work! #Nab3 #Nrd1 #Sen1 #NNS
A transcription termination mechanism for maintaining homogeneous protein expression url: academic.oup.com/nar/article/...

Congrats! #SSUprocessome #RNAExosome #rRNA

www.nature.com/articles/s41...

Unlocking the regulatory code of RNA: launching the Human RNome Project - Genome Biology The human RNome, the complete set of RNA molecules in human cells, arises through complex processing and includes diverse molecular species. While research traditionally focuses on four canonical nucl...

#RNA
genomebiology.biomedcentral.com/articles/10....

EXOSC10 haploinsufficiency causes primary microcephaly by derepression of Sonic hedgehog signalling Ulmke et al. show that mutations in EXOSC10 cause microcephaly. In mice, loss of Exosc10 leads to premature differentiation of neural progenitor cells, dis

#EXOSC10 #RNAExosome #RNA

academic.oup.com/brain/advanc...

Helicase-mediated mechanism of SSU processome maturation and disassembly Eukaryotic ribosomal small subunit (SSU) assembly requires the SSU processome, a nucleolar precursor containing the RNA chaperone U3 snoRNA. The underlying molecular mechanisms of SSU processome matur...

Tour de force stuff!

#SSU #Processome #RNAExosome

www.biorxiv.org/content/10.1...

Reaffirming the value of model organisms in training scientific minds - Nature Cell Biology As biomedical research prioritizes human models and translational promise, classic model organisms are increasingly dismissed. Here we argue that they have a lasting value, both in enabling discovery and in cultivating scientific thinking, by training researchers in systems reasoning, integrative thinking and independent inquiry.

Model organisms, in particular non-mammalian model organisms, such as yeast, Caenorhabditis elegans, #Drosophila and zebrafish, have long stood at the centre of biological discovery www.nature.com/articles/s41...

Time-resolved fluorescent proteins expand fluorescent microscopy in temporal and spectral domains (Cell 188, ◼◼◼–◼◼◼.e1–e14; November 26, 2025)

Time-resolved fluorescent proteins expand #fluorescent #microscopy in temporal and spectral domains: Cell www.cell.com/cell/fulltex...

Molecular basis of polyadenylated RNA fate determination in the nucleus Eukaryotic genomes generate a plethora of polyadenylated (pA+) RNAs[1][1],[2][2], that are packaged into ribonucleoprotein particles (RNPs). To ensure faithful gene expression, functional pA+ RNPs, in...

Nice!
#PolyARNA #RNA #Decay #Export #Nucleus

www.biorxiv.org/content/10.1...