Eliano dos Santos

ShineGAL4 FLP-out clones

#Drosophila calling. Delighted to share our new collection of ShineGAL4 drivers for CNS, FB, muscles, enterocytes, oenocytes and MTs made by @vgirard.bsky.social, @sebsorge.bsky.social and colleagues @crick.ac.uk. All at Bloomington @bdsc.bsky.social

@dev-journal.bsky.social
tinyurl.com/4jpw9jd6

Our public lecture are back! We've got
Richard Siow - @kingscollegelondon.bsky.social
Gordon Lithgow - @buckinstitute.org
Dawn Skelton - @glasgowcaledonian.bsky.social
@prof-valterlongo.bsky.social - @usc.edu
James Murry - @swanseauni.bsky.social

Tell friends & family, these are great talks!😀

The Origins of Agar First introduced into laboratories in 1881, agar remains indispensable as a culture medium.

I’m embarrassed to find how little I knew, or thought, about Agarose. Despite its efficacy, ubiquity & essential nature in labs.
Nor did I know anything about Fanny Angelina (another example, whether intentional or not, of the Matilda Effect) & Walther Hesse.
This is absolutely fascinating.

Joint A*STAR - King’s College London PhD Studentships in Biomedical Science 2026/27 King's College London is seeking outstanding and motivated students to join our university and the Agency for Science, Technology and Research (A*STAR).

Interested in nuclear mechanobiology in the heart and skin? Then @ylleecellbio.bsky.social and I have the PhD for you @kingscollegelondon.bsky.social and A* Star in Singapore www.kcl.ac.uk/study-legacy...

Thanks for posting these photos - really enjoyed participating at the #GERF2025 festival this summer! Our #FutureFoodLive demo featured PhD student alumnus Eliano and his research on #pH in #ageing, as well as delicious pretzels baked live on stage!
🥨👨‍🍳🥼🧪👩‍🔬

Young at heart Help Eliano Santos raise money to support British Heart Foundation

I’m running (walking really) the Royal Parks half marathon tomorrow to raise funds for the BHF and bring awareness to ageing as a modifiable risk factor for cardiovascular disease. Please donate here: www.justgiving.com/page/young-a...
❤️

Acidosis orchestrates adaptations of energy metabolism in tumors Malignant tumors are characterized by diverse metabolic stresses, including nutrient shortages, hypoxia, and buildup of metabolic by-products. To understand how cancer cells adapt to such challenges, ...

Acidosis orchestrates adaptations of energy metabolism in tumors | Science www.science.org/doi/10.1126/...

Chemotherapy modulation by a cancer-associated microbiota metabolite Martinez-Martinez et al. combine a host-microbe-drug-nutrient screen with multi-omics to reveal how the cancer-associated microbiota modulates chemotherapy. They identify 2-methylisocitrate, a microbi...

Excited to share our latest work at Cabreiro lab!

Chemotherapy modulation by a cancer-associated microbiota metabolite

www.cell.com/cell-systems...

Here's what we discovered 🧵

🚀 Introducing CroAGE – a #NextGenerationEU project advancing regulatory & comparative genomics in 🇭🇷 Croatia! We study gene promoters to understand how they control development & how tumours disrupt transcription.
🔗 croage.eu/en

Different ways to die: harnessing variation in Drosophila reveals loss of tolerance and resistance over age and sex-specific association between infection susceptibility and lifespan It is widely accepted that susceptibility to infection increases with age. The reason often invoked is the dysregulation of the immune system, which is both cause and consequence of ageing. However, w...

New preprint - varied routes to ⬆️ infection susceptibility over age - via bona fide immunosenescence, but also often via reduced tolerance 🪰🕰️🦠☠️

⬆️ risk to die from infection predicts lifespan in males. Great group effort from the lab!

www.biorxiv.org/content/10.1...

The "reproducibility crisis" in science constantly makes headlines. Repro efforts are often limited. What if you could assess reproducibility of an entire field?

That's what @brunolemaitre.bsky.social et al. have done. Fly immunity is highly replicable & offers lessons for #metascience

A 🧵 1/n

Check out the #LMSnews story on the @mrc-lms.bsky.social website about our latest study published in @natcomms.nature.com!

Illustrated by multi-talented first author #postdoc #painter @claudialennicke.bsky.social 💛 #redox #cysteine #sciart

Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...

🎉Excited to share our latest paper, published in Nature Communications!🎉

"Enhancing autophagy by redox regulation extends lifespan in Drosophila"

#redox #metabolism #ageing #Drosophila

@natcomms.nature.com @mrc-lms.bsky.social

doi.org/10.1038/s414...

The MIMIC lab is hiring a Postdoctoral Research Associate to join my team at @Cambridge_Uni!
Exploration and engineering DNA-mimicking proteins (wet-lab position.) 🧬
Details: www.jobs.cam.ac.uk/job/50652/
Please get in touch / circulate !

Lab’s latest: (mouse) mums grow their guts during pregnancy and lactation: www.cell.com/cell/fulltex...

Heterooligomerization drives structural plasticity of eukaryotic peroxiredoxins Peroxiredoxins are highly conserved thiol peroxidases essential for peroxide detoxification, redox signaling, and chaperone activity. Prx1/AhpC-type peroxiredoxins are found throughout the eukaryotic ...

Our first post on Bluesky!
1/ We are excited to share our latest work, showing that heterooligomerisation drives structural plasticity of Prx1-type peroxiredoxins.
www.biorxiv.org/content/10.1...

Another fantastic collaboration with the Marcel Deponte lab and Joris Messens lab!

Cellular and molecular contractile function in aged human skeletal muscle is altered by phosphate and acidosis and partially reversed with an ATP analog | American Journal of Physiology-Cell Physiology | American Physiological Society Skeletal muscle fatigue occurs, in part, from accumulation of hydrogen (H+) and phosphate (Pi); however, the molecular basis through which these ions inhibit function is not fully understood. Therefore, we examined the effects of these metabolites on myosin-actin cross-bridge kinetics and mechanical properties in skeletal muscle fibers from older (65-75 years) adults. Slow-contracting myosin heavy chain (MHC) I and fast-contracting MHC IIA fibers were examined under control (5 mM Pi, pH 7.0) and fatigue (30 mM Pi, pH 6.2) conditions at maximal calcium-activation (5 mM ATP) and rigor (0 mM ATP). In MHC I and IIA fibers, fatigue decreased force per fiber size (23-37%), which was accompanied by reduced strongly bound myosin head characteristics (number and/or stiffness; 21-47%) and slower cross-bridge kinetics (longer myosin attachment times (22-46%) and reduced rates of force production (20-33%)) compared with control. MHC I myofilaments became stiffer with fatigue, a potential mechanism to increase force production. In rigor, which causes the myosin that can bind actin to be strongly bound, fatigue decreased force per fiber size (32-33%) in MHC I and IIA fibers, indicating less force was generated per cross-bridge. By replacing ATP with 2-deoxy-ATP (dATP), the fatigue-induced slowing of cross-bridge kinetics in MHC I and IIA fibers was reversed and reduced force production in MHC I fibers was partially improved, revealing potential mechanisms to help mitigate fatigue in older adults. Overall, our results identify novel fiber type-specific changes in cross-bridge kinetics, force per cross-bridge, and myofilament stiffness that help explain fatigue in older adults.

Cellular and molecular contractile function in aged human skeletal muscle is altered by phosphate and acidosis and partially reversed with an ATP analog
journals.physiology.org/doi/abs/10.1...

Proteomic organ-specific ageing signatures and 20-year risk of age-related diseases: the Whitehall II observational cohort study Advanced proteomic organ ageing is associated with the long-term risk of age-related diseases. In most cases, faster ageing of a specific organ increases susceptibility to morbidity affecting multiple...

Accelerated aging in organs is linked to increased prevalence of disease - in most cases these diseases are not restricted to a specific organ showing systemic effects of aging: www.thelancet.com/journals/lan...

Longitudinal serum proteome mapping reveals biomarkers for healthy ageing and related cardiometabolic diseases - Nature Metabolism Tang, Yue, Xu and colleagues map the proteome of several thousand individuals over a 9-year period to identify potential biomarkers of ageing and of age-associated diseases.

RESEARCH | J Tang, T Guo, Y Chen, J Zheng (Westlake Univ, Sun Yat-sen Univ, CN) et al.:

This study maps the #proteome of several thousand individuals over a 9-year period to identify potential biomarkers of #ageing and of age-associated diseases.

https://bit.ly/4bbJJ4a

Are you coming to our next BSRA seminar? Prof Lene Juel Rasmussen, Copenhagen University will be speaking on Genes Associated with Human Longevity.

Spread the word, invite a friend, tell your students. Let's make this one our biggest!

4pm, 27th Feb online
bsra.org.uk/events/semin...

❤️Three year fully-funded post-CCT fellowship in Cardiac imaging / AI at @mrc-lms.bsky.social and @imperialcollegeldn.bsky.social. The Chain Florey Transition to Independence scheme offers a unique opportunity for early career clinicians. Closes 2nd March! www.imperial.ac.uk/jobs/search-...

Recommendations for mitochondria transfer and transplantation nomenclature and characterization - Nature Metabolism This Consensus Statement provides a nomenclature framework and experimental recommendations for studying mitochondrial transfer and transplantation.

CONSENSUS STATEMENT | Jonathan Brestoff, Keshav Singh (@mitoscientist.bsky.social) and colleagues bring us a#ConsensusStatement with a framework and recommendations for studying mitochondrial transfer and transplantation.

https://bit.ly/4hzkjPT

Today's the day! Our 2025 seminar series kicks off with @dweinkove.bsky.social, Chair of BSRA & Professor at @durhamuniversity.bsky.social with a seminar on 'Meeting the challenges of ageing: a biological approach'.

BSRA Member? Instructions on your email. Non-member? Join our mailing list!

Having taken part a couple of years ago, I could not recommend this course enough!
Apply to get daily talks about proper ageing research, work/play in the lab alongside great scientists, and go on a boat tour to collect some exotic species (or keep your eyes closed the whole time not to vomit) 🧑‍🔬⛵️

Introducing Human Domainome v1, the largest and most comprehensive library of human protein variants to date, which maps the effects of +500K mutations across 522 domains. The study by @benlehner.bsky.social and Toni Beltran is out now in @nature.com. Illustration by @queralttolosa.bsky.social.

Blocking the cell cycle inhibitor p21 prevents regrowth in lung cancer cells Blocking the activity of a protein called p21 stops lung cancer cells entering a ‘sleep-like’ state that allows them to survive chemotherapy. Blocking p21 causes more cancer cells to die and reduces t...

New research from Steve Cutty and @alexisbarr.bsky.social published in the British Journal of Cancer shows the protein p21 promotes survival in lung cancer cells strengthening the rationale for targeting p21 as a cancer treatment. This work was also funded by @cancerresearchuk.org

New PI positions @mrc-lms.bsky.social 👀 It's truly a great place to start a lab, definitely worth a look if you're on the job market. Please share with your networks!

Image of a PhD student next to a quote by him - “I immediately felt at home at the LMS thanks to my highly supportive research group and friendly research environment. The state-of-the-art building with its wonderful facilities makes it a true joy for me to come to work every day and contribute to the growing body of science in the field of human infertility”

The deadline to apply for our PhD studentships is fast approaching!

If you’d like to study a PhD at the LMS make sure to get your applications in by the 6th of December!

If our world class science isn't convincing enough, then hear what our students have to say

lms.mrc.ac.uk/work-and-stu...

PhD Studentship in Unravelling chromatin composition and interactome in ESKAPE pathogens at University of Cambridge on FindAPhD.com PhD Project - PhD Studentship in Unravelling chromatin composition and interactome in ESKAPE pathogens at University of Cambridge, listed on FindAPhD.com

Excited about prokaryotic chromatin and its role in pathogenic bacteria? Ambitious project to systematically characterize chromatin across ESKAPE pathogens! Wet & dry lab – Fully funded PhD available in our lab. Please share! www.findaphd.com/phds/project... #PhDPosition #Microbiology #Chromatin