Andreas Milias-Argeitis

TORC1 autonomously controls its spatial partitioning via the Rag GTPase tether Tco89 The eukaryotic target of rapamycin complex 1 (TORC1) kinase is a homeostatic regulator of growth, integrating nutritional cues at the endolysosomal co…

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@cp-cellreports.bsky.social: Tco89, an understudied TORC1 subunit in yeast, keeps upstream regulators and TORC1 together. Moreover, TORC1 controls Tco89 stability -> Spatial regulation through multisite phosphorylation!
www.sciencedirect.com/science/arti...

Gradient matching accelerates mixed-effects inference for biochemical networks AbstractMotivation. Single-cell time series data often exhibit significant variability within an isogenic cell population. When modeling intracellular proc

Our new paper introduces GMGTS, a highly efficient method for inferring parameter distributions of heterogeneous cell populations from time series data. A tour de force by Yulan van Oppen: doi.org/10.1093/bioi...

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