Joe Sabatino

🚨Job alert - please share🚨

Senior Research Fellow (Programme Manager, Neuroimmunology), Trinity College Dublin (TCD), Ireland.
my.corehr.com/pls/trrecrui...
Are you an experienced researcher keen for a unique challenge? Want to help set up and lead a new neuroimmunology research team/lab in TCD...

Stand Up For Science
National Day of Action
San Francisco, California
Saturday, March 7

Stand up for Science Stand up for Science

For those in the SF Bay area, please consider attending the SUFS rally this Saturday, March 7 at SF City Hall from 1-3 pm #standupforscience @standupforscience.bsky.social

fight2win.standupforscience.net/SF-March/

The Mettelman Lab at the University of Pittsburgh Center for Vaccine Research has officially opened its doors, and I’m looking to hire a Lab Manager!

If interested, please apply using the link below

Come join our team of 1!

cfopitt.taleo.net/careersectio...

Epstein‐Barr Virus Infection at Single‐Cell Resolution Epstein-Barr virus (EBV) infection has been studied at single-cell resolution for six decades and counting. Such investigations can reveal virus-host interactions and their dependence on viral strain...

Epstein-Barr Virus Infection at Single-Cell Resolution

onlinelibrary.wiley.com/doi/10.1002/...

STANFORD STAND UP FOR SCIENCE NATIONAL DAY OF ACTION RALLY LOCATION WHITE MEMORIAL PLAZA, STANFORD UNIVERSITY CAMPUS

STANFORD!!! Visit this link:
fight2win.standupforscience.net/Stanford-Mar...
to learn more about your local SATURDAY MARCH 7TH RALLY
to TAKE BACK OUR SCIENCE!

See map for location! Rally starts at 11am!!

#March7Stanford
#standupforscience
#science
#savescience

@biorxivpreprint.bsky.social Epigenomic profiling of cerebrospinal fluid cells identifies immune regulatory alterations and implicates protocadherins in multiple sclerosis
www.biorxiv.org/content/10.6... @ki.se

FlowCLOc, a New Tool for Selecting the Most Appropriate Antibodies in Flow Cytometry
www.mdpi.com/1422-0067/27...

Latent, Lytic, and Linked to Multiple Sclerosis—How EBV Drives Autoimmunity EBV latent and lytic genes uniquely contribute to Multiple Sclerosis development by various immunopathogenic mechanisms in susceptible hosts. Briefly, EBV infection shapes the B-cell repertoire and p...

Latent, Lytic, and Linked to Multiple Sclerosis—How EBV Drives Autoimmunity

onlinelibrary.wiley.com/doi/10.1002/...

Excited to announce the 1st International Conference on T cells in Health and Disease, a new conference series aiming to bring together T cell biologists across diverse areas, from fundamental biology through to clinical translation, and spanning infection, autoimmunity and cancer.

Interested in understanding how epitope recognition specificity is encoded in your TCR sequences? Try our new interactive page for building TCR specificity profiles on the TCR Motif Atlas: tcrmotifatlas.unil.ch/Building_mot....

Antibody-mediated feedback modulates interclonal competition in the germinal center Antibodies generated by prior immune responses regulate B cell responses upon recall immunization. Barbulescu et al. examine whether antibodies produced by an ongoing immune response influence the out...

One more trick pulled off by antibody-mediated feedback

www.cell.com/immunity/ful...

Metabolic quiescence of naive-like memory T cells precedes and maintains antigen-specific T cell memory - Nature Immunology Schober and colleagues show that effector CD8+ T cells undergo metabolic shutdown, CD8+ central memory T cells are the most metabolically active, and naive-like memory T cells are quiescent during the...

New work from our lab, hot off the press in Nature Immunology (@natureportfolio.nature.com)!

How do human T cell responses diversify — and how does this lead to durable protection after vaccination?

Paper: www.nature.com/articles/s41...

Press release: www.fau.eu/2026/02/news...

1/6

Great work from @hollenbachlab.bsky.social and Michael Wilson's lab at UCSF!

Histidine scanning identifies TCR hotspots capable of forming additional catch bonds, facilitating screens for low-affinity, higher-potency variants lacking off- & on-target toxicity @cellcellpress.bsky.social #Xu #Zhao #Gascoigne
www.cell.com/cell/fulltex...

Anti-CD20 Therapy Induces a Persistent Suppression of EBV–Host Interactions in Multiple Sclerosis Despite B-Cell Repopulation

papers.ssrn.com/sol3/papers....

🖨️ Hot off the press 🍾 :
I am super excited to share that our article on the host control of persistent EBV infection has just been published in Nature Magazine, in an accelerated article preview version:

rdcu.be/e4Lg8

Host control of persistent Epstein–Barr virus infection

www.nature.com/articles/s41...

N.I.H. Director Will Temporarily Run C.D.C. in Leadership Shake-Up

BREAKING: NIH director Jay Bhattacharya will take on the additional role of acting director of the Centers for Disease Control and Prevention, two administration officials told @sherylnyt.bsky.social on Wednesday.

Bhattacharya will also continue to run the NIH, she reports for @nytimes.com.

FDA reverses course, agrees to review Moderna’s flu vaccine The FDA reversed course and told Moderna it would review its application for a new flu vaccine, the company announced Wednesday.

#FDA backs down on #Moderna: The agency had refused to review the company's licensure application for an mRNA flu vaccine, but after significant pushback has relented. www.statnews.com/2026/02/18/f...

The Da Mesquita lab at Mayo Clinic (www.mayo.edu/research/lab...) is looking for a postdoctoral researcher to work on projects investigating the role(s) of the meningeal lymphatic vasculature in models of neurodegenerative diseases. Please spread the word and contact me in case you are interested! 😃

Choroid plexus enlargement associates with serum neurofilament and predicts relapse-free progression in multiple sclerosis The choroid plexus (CP), a key regulator of cerebrospinal fluid production and immune cell trafficking, is increasingly recognized as a potential magn…

Choroid plexus enlargement associates with serum neurofilament and predicts relapse-free progression in multiple sclerosis

www.sciencedirect.com/science/arti...

I am looking for an Illustrator to help with making schematics and diagrams.

Might anyone guide me on who to contact?

Thanks

#science #Illustration #Academia

Autoimmune neuroinflammation leads to neuronal death via MIF nuclease-mediated parthanatos Nature Neuroscience - Neuroinflammation triggers DNA damage and subsequent parthanatos-mediated neuron death. Inhibiting parthanatos in a mouse model of autoimmune inflammation is neuroprotective...

How does inflammation kill neurons, and what can we do about it? Check out our latest paper where we consider this question: rdcu.be/e4nfP.

Paper alert 📢: What drives variation in humoral responses to viruses? collab with @etienne-patin.bsky.social @darraghduffy.bsky.social @lquintanamurci.bsky.social we show that for ~98k viral epitopes immunodominance vary by genetics, sex and origin: www.nature.com/articles/s41...

Thanks so much!

@biorxivpreprint.bsky.social EBV reprograms autoreactive anti-CNS B cells as antigen presenting cells in multiple sclerosis
www.biorxiv.org/content/10.6... @stanforduniversity.bsky.social @shady-myounis.bsky.social

Congrats Todd & team @bruskolab.bsky.social
Large-scale TCR repertoire profiling from peripheral blood reveals type 1 diabetes signatures linked to high-risk HLA alleles
www.science.org/doi/10.1126/...

A high-throughput screening system enabled identification of the antigen targets of T cell receptors found in many individuals
www.science.org/doi/10.1126/...

Myelin sheaths in the central nervous system can withstand damage and dynamically remodel Myelin damage is a hallmark of several neurological disorders, but how it occurs remains to be fully understood. In this study, we found that early damage in zebrafish and rodent demyelination models ...

Myelin sheaths in the central nervous system can withstand damage and dynamically remodel | Science www.science.org/doi/10.1126/...