@imailab
Neuroscientist. Studying neuronal circuit development, chemical senses, and light microscopy-based connectomics. Professor at Kyushu University. Website: https://www.lab.med.kyushu-u.ac.jp/dn-en/ X: @TakeshiImaiLab
Our research on magneto-sensitive fluorescent proteins and some of their applications has now been published!
Huge thank you to the many many people involved in making this happen. π§ͺ
www.nature.com/articles/s41...
#ELMI2026 will take place in Coimbra, Portugal π΅πΉfrom June 16-19 hosted by @ppbioimaging.bsky.social colleagues. Submit your abstracts for oral presentations by January 18!
More information & registrationπ½
ppbi.pt/wordpress/in...
This is the result of the long-term efforts by Ryo Egashira and Meng-Tsen Ke, as well as our fruitful collaboration with @tsuyomiyakawa.bsky.social and Nao Nakagawa-Tamagawa. Congrats to the authors! (6/6)
L5 neurons are known to integrate sensory inputs to basal dendrites and top-down inputs to the apical tufts. The newly formed spines in the apical shaft may be critical for regulating dendritic integration. Also, dendritic integration in L5 may be affected by schizophrenia. (5/6)
We also found that mutations in schizophrenia-related genes impair adolescent spine formation, suggesting that spine formation in this specific dendritic compartment during adolescence is critical for the maturation of normal cognitive functions. (4/6)
It is well known that the βaverageβ spine density in the cortex decreases during adolescence. However, we found that spine density in the middle part of apical dendrites greatly increases during adolescence. This contrasts with basal dendrites, where spine density reduces. (3/6)
Using tissue clearing and super-resolution imaging, we found that spine density is highly skewed in apical dendrites of cortical L5 neurons in mice. The middle part had the highest spine density. In contrast, spine density was almost uniform in basal and oblique dendrites. (2/6)
Our new paper is out in Science Advances! We found that dendritic compartment-specific spine βformationβ during adolescence is critical for cortical development. We also found that schizophrenia-related genes are important in this process. (1/6)
www.science.org/doi/10.1126/...
In June 2001, I arrived in SFO with a suitcase, a student visa, and disproportionate dreams.
My life since has been nothing but a dream.
My heart is with the international students in the US today.
Our new paper is out in Science.
What is the synaptic plasticity rule in the brain, we asked. It turns out there are multiple, even within individual neurons.
Congrats Jake!
www.science.org/doi/10.1126/...
β¨New paper from my lab out now in @cp-cell.bsky.social!
We identified pathways for airway protective reflexesβswallowing and coughingβin mice, driven by rare throat chemosensory cells that signal vagal nerves via channel synapses.
cell.com/cell/fulltex...
If you are interested in what happens deep in the brain during puberty, please check our new paper in Neuron. We visualize how nutritional status shapes sexual maturation in female mice: A flagship study by an excellent postdoc Teppei Goto. (1/N
How does neural activity control developmental synapse elimination? Here is a new review paper from the lab: Activity-dependent synaptic competition and dendrite pruning in developing mitral cells.
www.frontiersin.org/journals/neu...
Feel free to use one from here if you like it: sites.google.com/site/seedbre...
A background in physics, and his own curiosity, have helped Dmitry Rinberg tackle the complexities of the neuroscience of smell. More on Rinberg sniffing out the mysteries of olfaction.
By Lina Zeldovich
www.thetransmitter.org/olfaction/sn...
The sympathetic nervous system may control selective organs, but how this specificity is achieved is unknown. Our new study
@NatureComms www.nature.com/articles/s41...γuncovers a parallel labeled-line organization within the lower thoracic spinal cord. 1/
We also made a linear unmixing plugin for ImageJ/Fiji. You can use a conventional confocal for 7-color imaging: github.com/daichimori/L...
Paper: www.nature.com/articles/s41...
Additional codes at Github: github.com/TakeshiImaiLab
Addgene: www.addgene.org/Takeshi_Imai/
From our recent paper: 7-color Tetbow image of the neocortexπ We can distinguish hundreds of neurons based on the combinatorial expression of 7 FPs.
Here is the list of plasmids for Tetbow experiments if you are interested (all available from Addgene): sites.google.com/site/seedbre...
Hello, this is my first Bluesky post! We love neuroimaging㪠Attached are covers from our lab featuring our favorite neurons, mitral cells in the olfactory bulb and L5 neurons in the neocortex. What's your #FavoriteNeuron?
