Timothy Hinks

Inflammatory and clinical risk factors for asthma attacks (ORACLE2): a patient-level meta-analysis of control groups of 22 randomised trials Blood eosinophil count, FeNO, asthma attack history, disease severity, low lung function (low FEV1%), and symptoms (ACQ-5 score) are key predictors of asthma attacks. Conversely, we found that moderat...

Simon and Fleur's new paper is out in The Lancet Respiratory Medicine!
ORACLE2 pooled 6,500+ asthma patients from 22 RCTs.
🧪 Blood eosinophils + FeNO = key predictors of asthma attacks
💨 Reversibility = lower risk?
Open access: www.thelancet.com/journals/lan...
#asthma #ORACLE2

Out today - a new role for MAIT cells. We've shown MAIT cells are antibacterial; antiviral; and promote tissue repair. In this paper from our group we show MAIT cells are recruited and activated to protect tissues in sterile lung injury, and potentially in IPF - enjoy!
doi.org/10.1016/j.ce...

It’s the little things in life: Lymph node microniches drive TH2 formation in allergic asthma Lymph node IL-2 microniches guide development of TH2 cells through induction of Blimp-1 expression and an IL-10–positive feedback loop.

1st post on Bluesky! Lovely little highlight of our recent publication by Adam Williams and Kelly Butler. Thanks for the fantastic summary! www.science.org/doi/10.1126/...

The 'Dream Combo' in #EosinophilicAsthma: for those on #asthma biologics with persistent mucopurulent cough additional long term, low dose azithromycin is highly effective. Gabriel's findings from @OxfordBRC out today in thorax.bmj.com/content/earl...

Infamous paper that popularized unproven COVID-19 treatment finally retracted Study on hydroxychloroquine by Didier Raoult and colleagues gets pulled on ethical and scientific grounds

This has taken such a long time to retract - the fraudulent study on potential of hydroxychloroquine as a COVID-19 treatment has done so much harm however not sure the incoming trump administration will take any note 😔🧪 www.science.org/content/arti...

Beyond classical immunity: Mast cells as signal converters between tissues and neurons Mast cells act as “signal converters,” translating immunological and tissue signals into host-protective behaviors. They sense antigen and possibly toxins driving avoidance behavior, which can prevent inflammation and tissue damage. Beyond classical immunity, mast cells rapidly activate antigen expulsion responses and initiate nociception. These reflexes promote host-protective behavior and maintain tissue integrity.

Beyond classical immunity: Mast cells as signal converters between tissues and neurons: Immunity www.cell.com/immunity/ful...

The new NICE/BTS/SIGN #Asthma guidelines are superb. A collaborative approach. A focus on using blood eos and FeNO at initial presentation and finally the long-overdue end to salbutamol. Read it and use it now www.nice.org.uk/guidance/NG245

Wonderful to see Imran Howell announced this year's BTS Young Investigator Award winner for delivering the BOOST trial. Well deserved!

When exacerbations of severe #asthma occur despite being on type 2 biologics, what residual inflammation remains? In our latest paper from @OxfordBRC we show prednisolone caused broad down regulation of type 2 pathways in pts on mepolizumab.
Full report: doi.org/10.1016/j.ja...

1 million people joined BlueSky today. Feels like time to exit X. Thanks for finding us here!

Species‐level, metagenomic and proteomic analysis of microbe‐immune interactions in severe asthma Paired long-read metagenomic sequencing and proteomics in sputum and nasal lavage identified a single dominant respiratory pathogen (H. influenzae more than M. catarrhalis and S. pneumoniae) in 23% o...

Editors pick this month in Allergy - Our new species-level study from @OxfordBRC shows severe #asthma microbiome is dominated by H. influenzae, M. catarrhalis and S. pneumoniae, driving
neutrophilic inflammation, airway proteases and disrupting regulatory immune responses: doi.org/10.1111/all....