Alberti Lab @ TU Dresden

Chaperones in focus: FLI heads new DFG research group on protein folding The German Research Foundation (DFG) is funding seven new research groups (FOR) with a total of €33 million. One of these, DFG-FOR 5872, is dedicated to the role of molecular chaperones in the regulat...

I'm very excited to announce the funding of a new DFG research unit FOR 5872 "Chaperone-mediated regulation of the emergence of disease-causing amyloids inside biomolecular condensates" that I lead together with Simon Alberti. More information can be found here: www.leibniz-fli.de/news-events/...

How does protein folding change inside biomolecular condensates?

Our new preprint put forwards a framework for predicting this!! 🥳🥳🥳🥳 work by the talented @nathanieldhess.bsky.social

Group Leader

We are thrilled to announce that our Postdoc Nagaraja Chappidi is starting his own research group at @mpi-cbg.de !

www.mpi-cbg.de/research/res...

++++ We are hiring ++++

The DFG-funded Research Training Group RTG 3120 – Biomolecular Condensates: From Physics to biological Functions” in Dresden is currently recruiting PhD-candidates.

More Info here: dresdencondensates.org/join-us/

Please apply until October 31,2025

Patrick's paper is finally out, a label-free method to measure the composition of multicomponent biomolecular condensates!

Congratulations to Kai Simons, one of our founding directors, for receiving the Cothenius-Medal of the German National Academy of Sciences Leopoldina @leopoldina.org for his insights into the function of cell membranes. 🎉 www.mpi-cbg.de/news-outreac...

🔬 #BSc or #MSc and research? Come to @tudresden.bsky.social & the CMCB!

Meet our iGEM team, supervised by @albertilab-tud.bsky.social and the Honigmann lab, ready for the @igemhq.bsky.social competition.

Video with EN subtitles ➡️ youtu.be/MMffDJyjeGg

#StudyinGermany #LifeSciences

Great trip to Prague with (part of) the team in perfect weather conditions.

Lively poster session after a day full of talks (😅) by @drummondlab.bsky.social, Allie Obermeyer, @albertilab-tud.bsky.social, Sam Safran, and @tanjamittag.bsky.social at the #KITP biomol25 conference on biomolecular condensates. Great conversations between theorists and experimentalists!

Molecule Disarms Cellular Stress Granules Linked to ALS Discovery by researchers in Dresden and Edinburgh points to new understanding of the onset of ALS.

A team @mpi-cbg.de from @hymanlab.bsky.social & the @edinburghup.bsky.social (Richard Wheeler group) has identified the molecule lipoamide that can prevent the formation of pathological stress granules - protein-rich condensates associated with cellular stress and ALS. www.mpi-cbg.de/news-outreac...

Collaboration with the Alberti lab @albertilab-tud.bsky.social here in Dresden @biotec-tud.bsky.social and Jeetain Mittal group in Texas jeetain.wixsite.com/mittal-lab
@rnadavid.bsky.social @pombo-garcialab.bsky.social

Picture of the PIs of TUD's Clusters of Excellence and Cluster of Excellence Initiatives beeing happy.

Picture of TUD's Rector Prof. Ursula Staudinger during the announcement of the funding decision of the DFG.

Picture of cheering guests in the ballroom of the Rectorate Building.

Picture of TUD's Rector Prof. Ursula Staudinger and cheering guests in the ballroom of the Rectorate Building.

Outstanding success: 🎉 #TUDresden shines with 5 Clusters of Excellence. @dfg.de & @wissenschaftsrat.de announced that decision today. TUD has impressively proven its claim to be a top university for the 21st century.
ℹ️ tu-dresden.de/tu-dresden/n...

Trigger warning: FOMO

How often do you go to a conference where you are excited about EVERY SINGLE TALK! Well, I guess it helps if you get to make the program. 😀

"Biomolecular condensates: From fundamental principles to applications in health and biotech" kicking off at 9 AM!

Das Leben erkennen: 🔬 Wie lassen sich Begegnungen von Molekülen sichtbar machen & was bedeutet das für die Entwicklung neuer Medikamente? Prof. Ulrich Rant stellt sich & seinen Forschungsschwerpunkt am 15.5. in der Universitätsweiten Antrittsvorlesung vor.
ℹ️ tu-dresden.de/tu-dresden/n...

Zellbiologie: Lebenswichtige Molekülklumpen »Biomolekulare Kondensate« in unseren Körperzellen organisieren die dortigen Abläufe und bieten neue Ansatzpunkte, um Krankheiten zu behandeln

Check out this interesting article about
#biomolecular #condensates (in German):

Lebenswichtige Molekülklumpen www.spektrum.de/news/lebensw...

#hymanlab.bsky.social #@rohitpappu68.bsky.social

This summer in beautiful Santa Barbara we will run a 3-day conference on “Biological Physics of Biomolecular Condensates: Bridging Theory and Experiment” June 16 to 18th. Register now: www.kitp.ucsb.edu/activities/b...

Backbone-mediated weakening of pairwise interactions enables percolation in peptide-based mimics of protein condensates - Communications Chemistry Biomolecular condensates formed by intrinsically disordered protein condensates are known to be semidilute solutions, however, the molecular interactions in the dilute versus dense phases remain under...

All atom simulations of peptides were used to investigate differences in pair interactions in dilute vs. dense phase mimics of condensates. Backbone-mediated interactions were found to weaken pairwise associations in dense phases giving rise to percolated networks. doi.org/10.1038/s420...

Welcome to our new Master students Samyuktha, Louis and Georg!
We wish you great success with your projects!.
It's wonderful to have you in the lab!

photos by Magdalena Gonciarz

Applications for our international and interdisciplinary Master's Programs are now open!

The applications start on April 1 and run until May 31, 2025.

For detailed information please visit our website
tu-dresden.de/cmcb/die-ein...

logo with a shark

The @tothpetroczylab.bsky.social together with the @albertilab-tud.bsky.social developed SHARK-capture to detect recurring patterns (motifs) in intrinsically disordered protein regions (IDRs). Publication in Protein Science. www.mpi-cbg.de/news-outreac...

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes - Nature Communications Nixon-Abell et al. show that ANXA11 condensation on lysosomal membranes causes a coupled phase transition of the underlying lipids and mechanical stiffening of the overall ensemble involved in RNP gra...

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes!

Annexin A11 tethers RNP granules to membranes in a Ca2+ dependent manner.

@abelljonny.bsky.social, @michael-e-ward.bsky.social, et al.

www.nature.com/articles/s41...

Cell published a “Cell Line: 2014–2024,” which is a timeline highlighting a set of exceptional scientific works published in @cellpress.bsky.social. The timeline features a publication from the @hymanlab.bsky.social & @albertilab-tud.bsky.social from 2015. www.cell.com/cell/pdf/S00...

Molecular determinants of condensate composition Cells use membraneless compartments to organize their interiors, and recent research has begun to uncover the molecular principles underlying their as…

Just finished this review by @alexholehouse.bsky.social & @albertilab-tud.bsky.social. Balanced, careful about overstatements or ambiguities, but also bold in making proposals as to how these things called condensates work, or how me might understand them, in an approximated but useful way, to work.

We are looking forward to the workshop "Biomolecular Condensates and Polymer Phase Transitions" which we are organizing together with the IPF Dresden (dpd.ipfdd.de).

It will be held from May 25th - 28th, 2025 in Meißen, near Dresden.

The registration deadline is May 5th, 2025.

Mysterious Blobs in Cells Are Changing the Way We Understand Life Tiny specks called biomolecular condensates are leading to a new understanding of the cell

In the cover story of the February issue of @sciam.bsky.social I explain what biomolecular condensates are and why they are transforming cell biology. A short 🧵
(You'll need a subscription to read the article.)
www.scientificamerican.com/article/myst...

🎉 Our Master’s programs are accredited until 2032!

🧬 Regenerative Biology and Medicine
🔬 Molecular Bioengineering
🌌 Physics of Life

✅ The programs went through internal quality check at TU Dresden and passed with flying colors!

Applications open April 1!
More info ➡️ tud.link/ynf76g

#Masters #MSc

Molecular determinants of condensate composition Biomolecular condensates are non-stochiometric assemblies that organize cellular matter in space and time. Despite much work, many questions remain regarding what determines the recruitment and exclus...

New review / perspective with @albertilab-tud.bsky.social on our thoughts on condensate speciality and recruitment, focusing on interplay between site specific and chemically specific interactions

www.cell.com/molecular-ce...