Really happy to have participated in this paper where we describe the role of PRKG1 as a clinical biomarker for Ipatasertib therapy in Rhabdomyosarcoma. Congratulations to everyone involved, and especially to Estela Prada, PhD for leading this great study.
www.nature.com/articles/s41...
Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances chemotherapy efficacy in Ewing sarcoma https://www.biorxiv.org/content/10.1101/2025.08.07.669049v1
The new findings of Alina Ritter showcase that this approach may be especially feasible for metastatic disease since an impirtant viral docking site is highly expressed in metastatic lesions and even contributes to metastasis in #Ewing #sarcoma.
We will not stop until there is a cure!
Based on the neomorphic DNA-binding capabilities of the Ewing sarcoma-specific EWSR1::ETS fusion oncoproteins, our expression constructs can deliver specifically produg convertases, (neo)-antigens, and cytokines to induce cell death only in Ewing cells, i.e. turn a 'cold' tumor 'hot'.
Since CXADR is a viral receptor, this study further paves the way for our novel virotherapy of #Ewing #sarcoma based on our 2022 study by @hoelting.bsky.social pioneering a suicde gene therapy induced by a Ewing sarcoma-specifc synthetic GGAA-enhancer
tinyurl.com/2sckk89m
Very proud on our stellar Alina Ritter for her frist first-author paper:
Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances #chemotherapy efficacy in #Ewing #sarcoma
tinyurl.com/3kcs3bc9
@dkfz.bsky.social
@uniheidelberg.bsky.social
@nct-heidelberg.bsky.social
So proud on our stellar medical student Florian H. Geyer for his first first-authorship paper!
Comprehensive #DSRCT multi-omics analyses unveil CACNA2D2 as a diagnostic hallmark and super-enhancer-driven EWSR1::WT1 signature gene
tinyurl.com/42fxmmud
@dkfz.bsky.social
@uniheidelberg.bsky.social
