Rudra Channappanavar

🗨️ Just published in Nature Biotechnology: Our CellWhisperer AI enables chat-based analysis of single-cell sequencing data. You can talk to your cells & figure out the biology without writing any computer code. Paper here: www.nature.com/articles/s41.... Annotated walkthrough in a thread below (1/11)

A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics - Nature Microbiology The authors developed a screen to find compounds that modulate intracellular Staphylococcus aureus metabolism and discovered KL1, which sensitizes persisters to antibiotics by reversing host-induced tolerance.

Delighted to share our latest paper - A host-directed adjuvant sensitizes intracellular bacterial persisters to antibiotics. Excellently led by Dr. Kuan-Yi Lu. We think it's a great proof-of-concept that altering immune cell behavior can make antibiotics work better www.nature.com/articles/s41...

Driven by the pain of endometriosis, this scientist is uncovering clues to its causes Katie Burns is helping reveal the immune system’s role in the long-neglected disease

www.science.org/content/arti...

Lei Yuan, Chen Dong et al. reveal that ciliated cells play an immunoregulatory role in allergic #asthma by constitutively expressing IL-17D, which limits #monocyte recruitment to inflamed lungs rupress.org/jem/article/...

In #Macrophages and #DendriticCells collection 👉 rupress.org/jem/collecti...

Jokichi Takamine The Japanese chemist helped isolate the hormone epinephrine and developed new methods of fermentation.

p.s. here's a brief biography of Jokichi Takamine
www.sciencehistory.org/education/sc...

Multi-layered deep immune profiling, SARS-CoV-2 RNAemia and inflammation in unvaccinated COVID-19 individuals with persistent symptoms - Communications Medicine Rovito et al. conduct deep immune profiling of hospitalized and unvaccinated individuals with persistent symptoms three months post COVID-19. They explore the role of SARS-CoV-2 RNAemia and peripheral...

Multi-layered deep immune profiling, SARS-CoV-2 RNAemia and inflammation in unvaccinated COVID-19 individuals with persistent symptoms

www.nature.com/articles/s43...

A proud mentor moment: Our lab wins all awards in grad student oral presentation category during a local Phi- Zeta Symposium at OSU College of Veterinary Medicine.

Roshan Ghimire- Honorary Mention
Cody Whitley- 1st Place
Debarati Chanda-2nd Place
Rakshya Shrestha- 3rd Place

a cartoon says hey everybody an old man 's talking while bart simpson looks on ALT: a cartoon says hey everybody an old man 's talking while bart simpson looks on

Bluetorial: Women, courage, and leadership

What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.

Influenza A virus rapidly adapts particle shape to environmental pressures - Nature Microbiology Quantitative flow virometry assay to measure the shape of viral particles under various conditions reveals that influenza virus infections dynamically tune shape distribution of progeny particles depending on viral efficiency.

A study in Nature Microbiology demonstrates that phenotypic flexibility allows influenza A virus to rapidly respond to environmental pressures in a way that provides dynamic adaptation potential in changing surroundings. 🧪

Cytokines in cancer Kureshi and Dougan discuss the roles of cytokines in the tumor microenvironment. Although there is a sophisticated understanding of cytokine networks, therapeutically targeting cytokine pathways in ca...

'Why we have evolved so many cytokines for so few transcriptional regulators is not entirely known, but it suggests that the diversity in cell types that can send a signal and cell types that can receive them is more important than diversity in transcriptional programs.'