Harsh Ranawat

Today the very first PhD student of Dodonova Lab has successfully defended his PhD Thesis!!🥳🥳🥳 And that with Honours, so well deserved!! Huge congratulation, dear @harshranawat.bsky.social !!!👏 Awesome PhD and awesome Defense!! Very happy and proud! And brilliant future ahead!👨‍🎓🎓🥳

Cryo-EM reveals open and closed Asgard chromatin assemblies Ranawat et al. show the cryo-EM structures of Asgard archaeal chromatin assemblies, revealing that the histone HHoB assembles into both compact closed and extended open hypernucleosomes. The closed co...

Let’s wrap things up: my commentary on the Asgard hypernucleosomes.

Congratulations to all the authors of the paper 🍾!

kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F...

Cryo-EM reveals open and closed Asgard chromatin assemblies: Molecular Cell www.cell.com/molecular-ce...

We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.

An Asgard archaeon with internal membrane compartments

Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!

www.biorxiv.org/content/10.1...

Congratulations ✨

Modulation of archaeal hypernucleosome structure and stability by Mg2+ DNA-wrapping histone proteins play a central role in chromatin organization, gene expression and regulation in most eukaryotes and archaea. While the …

New article online: Modulation of archaeal hypernucleosome structure and stability by Mg2+

In this work, we dissect the effects of Mg2+ on hypernucleosomes formed by the canonical histones from M. fervidus (HMfA and HMfB) and T. kodakarensis (HTkA and HTkB).

www.sciencedirect.com/science/arti...

Lab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️
Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...

Cryo-EM reveals open and closed Asgard chromatin assemblies Ranawat et al. show the cryo-EM structures of Asgard archaeal chromatin assemblies, revealing that the histone HHoB assembles into both compact closed and extended open hypernucleosomes. The closed conformation is conserved across archaea, while the open conformation represents an Asgard-specific innovation.

Online Now: Cryo-EM reveals open and closed Asgard chromatin assemblies Online now:

We’ve uncovered Asgard chromatin structures formed by a Hodarchaeal histone : closed hypernucleosome conserved in archaea and an open form resembling the H3-H4 eukaryotic octasome. Fantastic work by @harshranawat.bsky.social!
www.biorxiv.org/content/10.1...
#Chromatin #Asgard #Archaea #cryoEM