๐”„๐”ฏ๐”ซ๐”ž๐”ฒ๐”ก ๐”. ๐”๐”ข๐”ค๐”ฏ๐”ž๐”ซ๐”ก's Avatar

๐”„๐”ฏ๐”ซ๐”ž๐”ฒ๐”ก ๐”. ๐”๐”ข๐”ค๐”ฏ๐”ž๐”ซ๐”ก

@arnaudjlegrand

๐Ÿ‘จโ€๐Ÿ”ฌ Interdisciplinary #CancerResearch | CRUK Convergence Science Centre, The ICR & Imperial College London | #Metalhead ๐Ÿค˜| Views my own.

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Latest posts by ๐”„๐”ฏ๐”ซ๐”ž๐”ฒ๐”ก ๐”. ๐”๐”ข๐”ค๐”ฏ๐”ž๐”ซ๐”ก @arnaudjlegrand

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Our 2026 Annual Symposium brought together researchers from @imperialcollegeldn.bsky.social and @icr.ac.uk to showcase personalised diagnostics, convergence therapies and resistance monitoring.

The day showed how #Biology, #Engineering, #DataScience and clinical insight accelerate #CancerResearch

20.02.2026 12:15 ๐Ÿ‘ 2 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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๐Ÿ”ฅIt's #MetalFriday and I have a new entry in my AOTY list!

๐Ÿ‡ซ๐Ÿ‡ท Blut Aus Nord - Ethereal Horizons
๐ŸŽถAvant-garde Black Metal

A clear departure from previous opuses, more melodic and atmospheric, most definitely ethereal

#MetalHeads ##MetalSky

05.12.2025 12:01 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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๐ŸŽค Dr Wenjia Bai (@imperialcollegeldn.bsky.social)
๐Ÿซ€ Look into your heart: From image to mesh

๐ŸŽค Dr Matthew Blackledge (@icr.ac.uk)
๐Ÿ“ท Combining Bayesian Methods and AI for Improved Heterogeneous Imaging Biomarker Estimation in Whole-Body MRI of Advanced #ProstateCancer

24.11.2025 12:39 ๐Ÿ‘ 1 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Accelerating Pancreatic Cancer Test Adoption: A Multi-Stakeholder Call to Action A short film highlighting the challenges of translating new pancreatic cancer tests into GP settingsโ€”featuring clinicians, scientists, and patients calling on the NHS and stakeholders for faster adoption.

๐Ÿ’œNov is #PancreaticCancerAwarenessMonth. #PancreaticCancer remains hard to detect & treat, with slow improvements in survival.๐Ÿ™Thank you to those who supported this video, highlighting that progress relies on multistakeholder action to accelerate the adoption of early-detection tests. bit.ly/4rGiln1

28.11.2025 09:57 ๐Ÿ‘ 1 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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#4 ๐Ÿ‡ซ๐Ÿ‡ท The Great Old Ones - Kadath
๐ŸŽถ Atmospheric Black Metal

#5 ๐Ÿ‡ซ๐Ÿ‡ฎ Havukruunu - Tavastland
๐ŸŽถ Black Metal

๐Ÿค˜

29.11.2025 12:09 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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#2 ๐Ÿ‡ฎ๐Ÿ‡น Messa - The Spin
๐ŸŽถ Doom Metal

#3 ๐Ÿ‡จ๐Ÿ‡ญ Coroner - Dissonance Theory
๐ŸŽถ Technical Thrash Metal

29.11.2025 12:09 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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๐Ÿ”ฅI haven't done that in a long while and missed #MetalFriday, but here is my current top 5 metal albums of 2025 as ๐ŸŽ„is upon us.

#1 ๐Ÿ‡บ๐Ÿ‡ธ Deafheaven - Lonely People With Power
๐ŸŽถ Backgaze

#MetalHeads #MetalSky

29.11.2025 12:09 ๐Ÿ‘ 3 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

If the previous government hadnโ€™t been so hostile to the Humanities, they might have learned about the numerous state-run welfare programmes of the Roman Empire in *checks notes* the early Christian times.

29.11.2025 11:37 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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A study led by our Scientific Director Prof Axel Behrens, found that blocking protein SPP1 can boost survival & stop the spread of #PancreaticCancer in mice. A breakthrough that could pave the way for new targeted treatments.
๐Ÿ‘‰ bit.ly/4gTvG6q
@icr.ac.uk @imperialsandc.bsky.social @nature.com

30.09.2025 13:53 ๐Ÿ‘ 2 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

How does one go about electing a new Prince of Darkness? Or does what the Darkness giveth the Darkness taketh away and leaderless Metal will stay?

22.07.2025 18:41 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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๐Ÿšจ New cross-institutional study from researchers at @imperialcollegeldn.bsky.social, @icr.ac.uk & @cruk-mi.bsky.social use microfluidic โ€œvessel-on-chipโ€ technology to reveal how circulating tumour cells release โ€œshearosomesโ€ and promote metastasis.

๐Ÿ‘‰ bit.ly/3Ib6paq

#Cancer #ConvergenceScience

04.07.2025 12:35 ๐Ÿ‘ 2 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Published today @natmed.nature.com www.nature.com/articles/s41...
Thank you to all patients, families and research staff. @icr.ac.uk @icrdduiit.bsky.socialโ€ฌ โ€ช@icr-ctsu.bsky.social @royalmarsden.org @ecmc-uk.bsky.socialโ€ฌ
@nihr.bsky.social @crukconvergence.bsky.social @cancerresearchuk.org

โ€ช

27.06.2025 10:48 ๐Ÿ‘ 4 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Microtubules in Asgard archaea Discovery of heterodimeric, microtubule-forming tubulins in Asgard archaea, the closest known relatives of eukaryotes, reveals snapshots of microtubule evolution.

Now online! Microtubules in Asgard archaea

21.03.2025 18:51 ๐Ÿ‘ 53 ๐Ÿ” 24 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 5

And tusks! No tusks no Mamouse!

05.03.2025 08:20 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Metabolic engineering to facilitate anti-tumor immunity While high fructose intake has been implicated in the progression of metabolic disease and cancer, Schild etย al. take advantage of the availability of fructose in the tumor microenvironment. Engineere...

Metabolic engineering to facilitate anti-tumor immunity

www.cell.com/cancer-cell/...

28.02.2025 08:10 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Intrinsic electrical activity drives small-cell lung cancer progression - Nature Electrical excitability in neuroendocrine SCLC cells promotes tumour progression through action potential firing, increasing ATP demand and oxidative phosphorylation dependency, whereas non-neuroendoc...

๐Ÿ‘€ Intrinsic electrical activity drives small-cell lung cancer progression

www.nature.com/articles/s41...

12.02.2025 19:45 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Protein codes promote selective subcellular compartmentalization Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...

Protein codes promote selective subcellular compartmentalization | Science

www.science.org/doi/10.1126/...

09.02.2025 08:50 ๐Ÿ‘ 3 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Engineered commensals for targeted nose-to-brain drug delivery Shen etย al. investigate the use of Lactobacillus plantarum, a commensal bacterial strain, as a chassis for targeting the olfactory mucosa to facilitate precise nose-to-brain delivery of therapeutic mo...

Engineered commensals for targeted nose-to-brain drug delivery: Cell

www.cell.com/cell/fulltex...

06.02.2025 19:38 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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High-resolution spatially resolved proteomics of complex tissues based on microfluidics and transfer learning PLATO, a high-resolution and high-throughput spatial mass spectrometry proteomics platform, identifies distinct tumor subtypes and key dysregulated proteins in human breast cancer.

๐Ÿ“ฐHigh-resolution spatially resolved proteomics of complex tissues based on microfluidics and transfer learning

www.cell.com/cell/fulltex...

24.01.2025 08:19 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature Mitochondria with mutations in their DNA from cancer cells can be transferred to Tโ€‰cells in the tumour microenvironment, which leads to Tโ€‰cell dysfunction and impaired antitumour immunity.

Immune evasion through mitochondrial transfer in the tumour microenvironmenthttps://

www.nature.com/articles/s41586-024-08439-0

22.01.2025 18:54 ๐Ÿ‘ 16 ๐Ÿ” 8 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Rapid and scalable personalized ASO screening in patient-derived organoids - Nature A scalable platform for generating patient-specific organoids for testing personalized oligonucleotide therapeutics is described.

Rapid and scalable personalized ASO screening in patient-derived organoids

www.nature.com/articles/s41...

22.01.2025 19:37 ๐Ÿ‘ 3 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Targeting BRCA1-deficient PARP inhibitor-resistant cells with nickases reveals nick resection as a cancer vulnerability Nature Cancer - Whalen et al. report that increased DNA end resection in BRCA-deficient, PARP inhibitor-resistant cancers leads to increased sensitivity to DNA nicks, limiting tumor formation in...

Congratulations to Jenna Whalen on her Nature Cancer paper out today-a distinct take on nicks and their toxicity! rdcu.be/d60Td

21.01.2025 17:26 ๐Ÿ‘ 56 ๐Ÿ” 27 ๐Ÿ’ฌ 3 ๐Ÿ“Œ 1
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Imperial receives ยฃ15m ARIA funding for breakthrough brain research | Imperial News | Imperial College London Imperial researchers will receive almost ยฃ15m in funding to embark on cutting edge research to help overcome neurodegenerative disease.

๐Ÿง  How can we safely target structures deep inside the brain linked to disease?

Imperial researchers hope to find out, thanks to ARIA funding!

The project will develop minimally invasive brain stimulation methods to target regions and influence their activity ๐Ÿ”ฝ

www.imperial.ac.uk/news/260073/...

20.01.2025 10:16 ๐Ÿ‘ 10 ๐Ÿ” 3 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Deciphering functional tumor-immune crosstalk through highly multiplexed imaging and deep visual proteomics Xiang Zheng etย al. develop an advanced approach combining multiplexed imaging and deep visual proteomics to spatially map the tumor microenvironment. By analyzing colorectal and tonsil cancer tissues,...

Deciphering functional tumor-immune crosstalk through highly multiplexed imaging and deep visual proteomics

www.cell.com/molecular-ce...

15.01.2025 08:27 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Therapeutic ultrasound is a prime example of convergence science - using the physics behind high frequency waves and applying it to biological systems to better diagnose, monitor and even target specific tumour sites. We support research that harnesses the power of ultrasound technologies. 1/3

14.01.2025 16:37 ๐Ÿ‘ 3 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

Other mentions go to:

๐Ÿ‡บ๐Ÿ‡ธ #ChatPile - Cool World
๐Ÿ‡จ๐Ÿ‡ญ #Paysaged'Hiver - Die Berge
๐Ÿ‡บ๐Ÿ‡ธ #Huntsmen - The Dry Land
๐Ÿ‡ณ๐Ÿ‡ฟ #Ulcerate - Cutting The Throat Of God
๐Ÿ‡ฌ๐Ÿ‡ท #HailSpiritNoir - Fossil Gardens
๐Ÿ‡ฎ๐Ÿ‡ธ #Mรบr - Mโ€‹รบโ€‹r
๐Ÿ‡ซ๐Ÿ‡ท #Seth - La France Des Maudits
๐Ÿ‡บ๐Ÿ‡ธ #BleakHeart - Silver Pulse
& ๐Ÿ‡ฉ๐Ÿ‡ช #Motherwood - A Fading Elegy

10.01.2025 18:42 ๐Ÿ‘ 2 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Blood Incantation - Absolute Elsewhere

Blood Incantation - Absolute Elsewhere

Hamferรฐ - Men Guโ€‹รฐโ€‹s Hond Er Sterk

Hamferรฐ - Men Guโ€‹รฐโ€‹s Hond Er Sterk

And finally my top 2 for 2024:

*2 ๐Ÿ‡บ๐Ÿ‡ธ #BloodIncantation - Absolute Elsewhere (Death Metal)

And ๐Ÿฅ

*1 ๐Ÿ‡ซ๐Ÿ‡ด #Hamferรฐ - Men Guโ€‹รฐโ€‹s Hond Er Sterk (Doom Metal)

#MetalHeads #MetalSky

10.01.2025 18:42 ๐Ÿ‘ 3 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
Tribulation - Sub Rosa In ร†ternum

Tribulation - Sub Rosa In ร†ternum

Rezn - Burden

Rezn - Burden

Ihsahn - Ihsahn

Ihsahn - Ihsahn

Iotunn - Kinship

Iotunn - Kinship

Continuing at:

*6 ๐Ÿ‡ธ๐Ÿ‡ช #Tribulation - Sub Rosa In ร†ternum (Gothic Metal)

*5 ๐Ÿ‡บ๐Ÿ‡ธ #Rezn - Burden (Stoner Metal)

*4 ๐Ÿ‡ณ๐Ÿ‡ด #Ihsahn - Ihsahn (Ext. Prog. Metal)

*3 ๐Ÿ‡ฉ๐Ÿ‡ฐ #Iotunn - Kinship (Melodic Death Metal)

#MetalHeads #MetalSky

10.01.2025 18:42 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
Alcest - Les Chants De L'Aurore

Alcest - Les Chants De L'Aurore

Gaerea - Coma

Gaerea - Coma

รrstรญรฐirLรญfsins - Aldrlok

รrstรญรฐirLรญfsins - Aldrlok

Wintersun - Time II

Wintersun - Time II

๐Ÿ”ฅIt's #MetalFriday! Time for my #AOTY 2024!

Great millesime for \m/ music

Starting at:

*10 ๐Ÿ‡ซ๐Ÿ‡ท #Alcest - Les Chants De L'Aurore (Blackgaze)

*9 ๐Ÿ‡ต๐Ÿ‡น #Gaerea - Coma (Black Metal)

*8 ๐Ÿ‡ฎ๐Ÿ‡ธ #รrstรญรฐirLรญfsins - Aldrlok (Black/Folk Metal)

*7 ๐Ÿ‡ซ๐Ÿ‡ฎ #Wintersun - Time II (Ext. Power Metal)

#MetalHeads #MetalSky

10.01.2025 18:42 ๐Ÿ‘ 4 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells Expanding the consequences of pyroptosis, this study reveals that GSDMD pore-laden pyroptotic EVs transplant GSDMD pores on neighboring cell surfaces and propagate cell death to bystander cells.

๐Ÿ“ฐTransplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells

www.cell.com/cell/abstrac...

01.01.2025 09:33 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0