𝔄𝔯𝔫𝔞𝔲𝔡 𝔍. 𝔏𝔢𝔤𝔯𝔞𝔫𝔡

Our 2026 Annual Symposium brought together researchers from @imperialcollegeldn.bsky.social and @icr.ac.uk to showcase personalised diagnostics, convergence therapies and resistance monitoring.

The day showed how #Biology, #Engineering, #DataScience and clinical insight accelerate #CancerResearch

🔥It's #MetalFriday and I have a new entry in my AOTY list!

🇫🇷 Blut Aus Nord - Ethereal Horizons
🎶Avant-garde Black Metal

A clear departure from previous opuses, more melodic and atmospheric, most definitely ethereal

#MetalHeads ##MetalSky

🎤 Dr Wenjia Bai (@imperialcollegeldn.bsky.social)
🫀 Look into your heart: From image to mesh

🎤 Dr Matthew Blackledge (@icr.ac.uk)
📷 Combining Bayesian Methods and AI for Improved Heterogeneous Imaging Biomarker Estimation in Whole-Body MRI of Advanced #ProstateCancer

Accelerating Pancreatic Cancer Test Adoption: A Multi-Stakeholder Call to Action A short film highlighting the challenges of translating new pancreatic cancer tests into GP settings—featuring clinicians, scientists, and patients calling on the NHS and stakeholders for faster adoption.

💜Nov is #PancreaticCancerAwarenessMonth. #PancreaticCancer remains hard to detect & treat, with slow improvements in survival.🙏Thank you to those who supported this video, highlighting that progress relies on multistakeholder action to accelerate the adoption of early-detection tests. bit.ly/4rGiln1

#4 🇫🇷 The Great Old Ones - Kadath
🎶 Atmospheric Black Metal

#5 🇫🇮 Havukruunu - Tavastland
🎶 Black Metal

🤘

#2 🇮🇹 Messa - The Spin
🎶 Doom Metal

#3 🇨🇭 Coroner - Dissonance Theory
🎶 Technical Thrash Metal

🔥I haven't done that in a long while and missed #MetalFriday, but here is my current top 5 metal albums of 2025 as 🎄is upon us.

#1 🇺🇸 Deafheaven - Lonely People With Power
🎶 Backgaze

#MetalHeads #MetalSky

If the previous government hadn’t been so hostile to the Humanities, they might have learned about the numerous state-run welfare programmes of the Roman Empire in *checks notes* the early Christian times.

A study led by our Scientific Director Prof Axel Behrens, found that blocking protein SPP1 can boost survival & stop the spread of #PancreaticCancer in mice. A breakthrough that could pave the way for new targeted treatments.
👉 bit.ly/4gTvG6q
@icr.ac.uk @imperialsandc.bsky.social @nature.com

How does one go about electing a new Prince of Darkness? Or does what the Darkness giveth the Darkness taketh away and leaderless Metal will stay?

🚨 New cross-institutional study from researchers at @imperialcollegeldn.bsky.social, @icr.ac.uk & @cruk-mi.bsky.social use microfluidic “vessel-on-chip” technology to reveal how circulating tumour cells release “shearosomes” and promote metastasis.

👉 bit.ly/3Ib6paq

#Cancer #ConvergenceScience

Published today @natmed.nature.com www.nature.com/articles/s41...
Thank you to all patients, families and research staff. @icr.ac.uk @icrdduiit.bsky.social‬ ‪@icr-ctsu.bsky.social @royalmarsden.org @ecmc-uk.bsky.social‬
@nihr.bsky.social @crukconvergence.bsky.social @cancerresearchuk.org

‪

Microtubules in Asgard archaea Discovery of heterodimeric, microtubule-forming tubulins in Asgard archaea, the closest known relatives of eukaryotes, reveals snapshots of microtubule evolution.

Now online! Microtubules in Asgard archaea

And tusks! No tusks no Mamouse!

Metabolic engineering to facilitate anti-tumor immunity While high fructose intake has been implicated in the progression of metabolic disease and cancer, Schild et al. take advantage of the availability of fructose in the tumor microenvironment. Engineere...

Metabolic engineering to facilitate anti-tumor immunity

www.cell.com/cancer-cell/...

Intrinsic electrical activity drives small-cell lung cancer progression - Nature Electrical excitability in neuroendocrine SCLC cells promotes tumour progression through action potential firing, increasing ATP demand and oxidative phosphorylation dependency, whereas non-neuroendoc...

👀 Intrinsic electrical activity drives small-cell lung cancer progression

www.nature.com/articles/s41...

Protein codes promote selective subcellular compartmentalization Cells have evolved mechanisms to distribute ~10 billion protein molecules to subcellular compartments where diverse proteins involved in shared functions must assemble. Here, we demonstrate that prote...

Protein codes promote selective subcellular compartmentalization | Science

www.science.org/doi/10.1126/...

Engineered commensals for targeted nose-to-brain drug delivery Shen et al. investigate the use of Lactobacillus plantarum, a commensal bacterial strain, as a chassis for targeting the olfactory mucosa to facilitate precise nose-to-brain delivery of therapeutic mo...

Engineered commensals for targeted nose-to-brain drug delivery: Cell

www.cell.com/cell/fulltex...

High-resolution spatially resolved proteomics of complex tissues based on microfluidics and transfer learning PLATO, a high-resolution and high-throughput spatial mass spectrometry proteomics platform, identifies distinct tumor subtypes and key dysregulated proteins in human breast cancer.

📰High-resolution spatially resolved proteomics of complex tissues based on microfluidics and transfer learning

www.cell.com/cell/fulltex...

Immune evasion through mitochondrial transfer in the tumour microenvironment - Nature Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired antitumour immunity.

Immune evasion through mitochondrial transfer in the tumour microenvironmenthttps://

www.nature.com/articles/s41586-024-08439-0

Rapid and scalable personalized ASO screening in patient-derived organoids - Nature A scalable platform for generating patient-specific organoids for testing personalized oligonucleotide therapeutics is described.

Rapid and scalable personalized ASO screening in patient-derived organoids

www.nature.com/articles/s41...

Targeting BRCA1-deficient PARP inhibitor-resistant cells with nickases reveals nick resection as a cancer vulnerability Nature Cancer - Whalen et al. report that increased DNA end resection in BRCA-deficient, PARP inhibitor-resistant cancers leads to increased sensitivity to DNA nicks, limiting tumor formation in...

Congratulations to Jenna Whalen on her Nature Cancer paper out today-a distinct take on nicks and their toxicity! rdcu.be/d60Td

Imperial receives £15m ARIA funding for breakthrough brain research | Imperial News | Imperial College London Imperial researchers will receive almost £15m in funding to embark on cutting edge research to help overcome neurodegenerative disease.

🧠 How can we safely target structures deep inside the brain linked to disease?

Imperial researchers hope to find out, thanks to ARIA funding!

The project will develop minimally invasive brain stimulation methods to target regions and influence their activity 🔽

www.imperial.ac.uk/news/260073/...

Deciphering functional tumor-immune crosstalk through highly multiplexed imaging and deep visual proteomics Xiang Zheng et al. develop an advanced approach combining multiplexed imaging and deep visual proteomics to spatially map the tumor microenvironment. By analyzing colorectal and tonsil cancer tissues,...

Deciphering functional tumor-immune crosstalk through highly multiplexed imaging and deep visual proteomics

www.cell.com/molecular-ce...

Therapeutic ultrasound is a prime example of convergence science - using the physics behind high frequency waves and applying it to biological systems to better diagnose, monitor and even target specific tumour sites. We support research that harnesses the power of ultrasound technologies. 1/3

Other mentions go to:

🇺🇸 #ChatPile - Cool World
🇨🇭 #Paysaged'Hiver - Die Berge
🇺🇸 #Huntsmen - The Dry Land
🇳🇿 #Ulcerate - Cutting The Throat Of God
🇬🇷 #HailSpiritNoir - Fossil Gardens
🇮🇸 #Múr - M​ú​r
🇫🇷 #Seth - La France Des Maudits
🇺🇸 #BleakHeart - Silver Pulse
& 🇩🇪 #Motherwood - A Fading Elegy

Blood Incantation - Absolute Elsewhere

Hamferð - Men Gu​ð​s Hond Er Sterk

And finally my top 2 for 2024:

*2 🇺🇸 #BloodIncantation - Absolute Elsewhere (Death Metal)

And 🥁

*1 🇫🇴 #Hamferð - Men Gu​ð​s Hond Er Sterk (Doom Metal)

#MetalHeads #MetalSky

Tribulation - Sub Rosa In Æternum

Rezn - Burden

Ihsahn - Ihsahn

Iotunn - Kinship

Continuing at:

*6 🇸🇪 #Tribulation - Sub Rosa In Æternum (Gothic Metal)

*5 🇺🇸 #Rezn - Burden (Stoner Metal)

*4 🇳🇴 #Ihsahn - Ihsahn (Ext. Prog. Metal)

*3 🇩🇰 #Iotunn - Kinship (Melodic Death Metal)

#MetalHeads #MetalSky

Alcest - Les Chants De L'Aurore

Gaerea - Coma

ÁrstíðirLífsins - Aldrlok

Wintersun - Time II

🔥It's #MetalFriday! Time for my #AOTY 2024!

Great millesime for \m/ music

Starting at:

*10 🇫🇷 #Alcest - Les Chants De L'Aurore (Blackgaze)

*9 🇵🇹 #Gaerea - Coma (Black Metal)

*8 🇮🇸 #ÁrstíðirLífsins - Aldrlok (Black/Folk Metal)

*7 🇫🇮 #Wintersun - Time II (Ext. Power Metal)

#MetalHeads #MetalSky

Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells Expanding the consequences of pyroptosis, this study reveals that GSDMD pore-laden pyroptotic EVs transplant GSDMD pores on neighboring cell surfaces and propagate cell death to bystander cells.

📰Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells

www.cell.com/cell/abstrac...