Ragothaman Yennamalli's Avatar

Ragothaman Yennamalli

@structbioinfo

Sr. Asst Prof SASTRA Univ | Computational Biologist | YIM2024 organizer | Editor: CSBJ, BMC Bioinfo | Spl issue Ed: Biophys J | He/Him.

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08.08.2023
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Latest posts by Ragothaman Yennamalli @structbioinfo

Wow!!!! This is HUGE!!!

05.03.2026 14:01 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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🚨🚨🚨Happy to share that our Tutorial proposals got accepted for #ISMB2026 and #ECCB2026!!! Flagship events of @iscb.bsky.social πŸŽ‰πŸŽ‰πŸŽ‰ Looking forward working with Farzana, Shashank, Meg, and JC.
eccb2026.org/tutorials-wo... www.iscb.org/ismb2026/wha...

05.03.2026 12:47 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Today, I am excited to listen to Best of Biophysical Journal symposium!

24.02.2026 17:58 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Met Prof. Bob Jernigan, after 15 years! Also met our bioinformatics alumni Jaya Vasavi. Yesterday's posters were super good! Had a good time. Also, it was nice reconnecting with Harpreet Singh from THE Ohio State Univ. We met first in 2012.

24.02.2026 17:56 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 1

The day ended with conference swag collection and topped with collecting the certificate for curating the special issue of
@biophysj.bsky.social @biophysicalsoc.bsky.social
from EiC @frettinglab.bsky.social and John Long! This was a surprise...πŸ’—πŸ’• Super proud of how the issue turned out!

23.02.2026 13:09 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 1

Today was a great day with a dedicated session on science communication with Jeremy Berg, Holden Thorpe, and Daniel Cohen talking about why scicomm is a must in today's time. Also, my favorite Darwin quote. Met a few friends and other ambassadors as well!!!

23.02.2026 13:08 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 1

An amazing set of talks in the theory and computation subgroup. Met a couple of friends. And ended with dinner with my postdoc supervisor with lots of things catching up over delicious turkish food!!!

22.02.2026 05:51 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 1
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Today we start the Biophysical society meeting!!! And I met my PhD co-supervisor Bostjan Kobe from The University of Queensland, Australia after 20 years!!!! Exciting day ahead...

22.02.2026 05:51 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 1

vibe coding != blind coding #vibecoding

12.02.2026 18:09 πŸ‘ 6 πŸ” 1 πŸ’¬ 4 πŸ“Œ 0

At the fringes of the BlueSky user galaxy, but in good company!

09.02.2026 11:35 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
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I am SO incredibly excited to announce the launch of a global list of Inspiring Black Scientists. You can use this list to nominate and connect with researchers. Please share and join us in highlighting these outstanding scientists for #BlackHistoryMonth and beyond!

www.wiley.com/en-us/resear...

05.02.2026 17:36 πŸ‘ 135 πŸ” 79 πŸ’¬ 3 πŸ“Œ 8

Wishing you the best in the next endeavors!!!

30.01.2026 06:29 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 1

For many years, we never had institutional email ids. As a postdoc I had an .edu address, until then I had used my .com address. There are so many institutions on this side of the world where .com addresses are still used for official academic communications by students.

27.01.2026 07:25 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Also, the variant data is available in European Variant Archive. ebi.ac.uk/eva/?eva-stu...

Read our preprint here: bsky.app/profile/bior...

23.01.2026 00:14 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

🌱 Why this matters
These results provide a curated set of innate immune gene candidates for:
β€’ Disease-resilient breeding
β€’ Climate-adapted livestock
β€’ Future functional validation
7/8

23.01.2026 00:14 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

πŸ”— Genotype meets function
By integrating PBMC gene-expression data, we show that several immune genes with genomic variants also show distinct basal expression in healthy indicine cattle.

Genomic variation means functional immune readiness.
6/8

23.01.2026 00:14 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

🧬 Population genomics tells the story
PCA, FST, dXY, and selective sweep analyses reveal:
β€’ Clear indicine–taurine separation
β€’ Strong immune-gene divergence
β€’ Breed-specific selection signals
Pathogen pressure leaves a genomic signature.
5/8

23.01.2026 00:14 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

🧠 Key finding #2
Two innate immune genes stand out:
πŸ‘‰ CARD9
πŸ‘‰ NLRP8

High-impact, indicine-specific variants were found in all four indicine breeds, but were absent in taurine and crossbred cattle.
4/8

23.01.2026 00:14 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

This is a genome-wide view of innate immunity. Key Finding #1:
Indicine breeds carry more immune-related variants than taurine and crossbred cattleβ€”
across structural variants, copy-number changes, and high-impact SNVs.

This isn’t just diversityβ€”it’s adaptation.
3/8

23.01.2026 00:14 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

We tackle this using integrative whole-genome analysis across indicine, taurine, and crossbred cattle.
πŸ“Š Study design at a glance
β€’ >100 animal samples
β€’ 6 breeds (4 indicine, 1 taurine, 1 crossbreed)
β€’ Whole-genome seq
β€’ SNVs, InDels, CNVs, SVs + population genomics
2/8

23.01.2026 00:14 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Fantastic way to start the year πŸŽ‰ with a preprint from Yennamalli Lab! This is a ICAR-NASF funded project in collaboration with NDRI, Karnal!
What makes indicine cattle naturally resilient to infections and harsh environments? A πŸ§΅πŸ‘‡πŸ§¬ 1/8

23.01.2026 00:14 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
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Prime numbers 2-4999, animated with ggplot2+gganimate.

#Rstats code: gist.github.com/stephenturne...

20.01.2026 10:13 πŸ‘ 67 πŸ” 21 πŸ’¬ 6 πŸ“Œ 2

I would love to be a student in this course!

12.01.2026 03:27 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

They smell like heaven!!!

11.01.2026 13:11 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
What is there in an Indian Thali? The Centre for Visual Information Technology (CVIT) is a research centre at the International Institute of Information Technology, Hyderabad.

Also @vikasnavaratna.bsky.social there is this: cvit.iiit.ac.in/research/pro...

09.01.2026 23:34 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

LOL!!! I will read the paper now more throughly.

09.01.2026 23:26 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Preview
How Does India Cook Biryani? A large-scale dataset and VLM-based pipeline for analyzing procedural differences across 12 regional Indian biryani variants using 120 cooking videos.

@vikasnavaratna.bsky.social This is right up your alley! farzanashaju.github.io/how-does-ind...
Haven't read it fully, yet! Sounds interesting...

09.01.2026 16:04 πŸ‘ 2 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

Thanks and congratulations to you as well for selected as an BPS Ambassdor, Canada! And being in the same cohort!!! πŸ₯³πŸŽ‰

09.01.2026 14:42 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

It is perhaps not hungry enough!πŸ˜‚

09.01.2026 14:41 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

I don't see your posts these days. Some algorithm. Missed seeing all these food pics for a long time.

09.01.2026 08:11 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0