Georgios Petrellis, DVM, M.Sc.

Brief 🧵 on current job opportunities at the Center for Cancer #Immunotherapy & Immunobiology at Kyoto University.
#Immunology #Immunosky

We are #hiring! Please help share!

Postdoc in #Immunology; B-cell biology

We are recruiting a postdoc to lead projects on human B cells and plasma cells funded by the Gates Foundation and the NIH (The position is fully funded and not dependent on future grants).

ghosnlab.science/join-us

CD209d/e are required for macrophage-mediated phagocytosis and activation during methicillin-resistant Staphylococcus aureus pulmonary host defense Abstract. Staphylococcus aureus is a commensal and opportunist pathogen of the upper respiratory tract. The recognition of pathogen-associated molecular pa

Methicillin-resistant S. aureus (#MRSA) causes difficult-to-treat infections in humans. #ICYMI: Data suggest that CD209d/e are essential receptors to control inflammation by activating macrophages leading to MRSA uptake and killing. Learn more: ow.ly/ba8250VU8c7.

A list of confirmed speakers, plus a photo of the hotel and logos of our sponsors.

📢 Only one week to go!

We are very thrilled about our upcoming first CiViA #symposium 'Defense against #viral infections 🦠 ', which will take place on 21 & 22 May 2025 at Hotel Vejlefjord, #Denmark 🇩🇰.

Stay tuned for further updates!

Supported by @dg.dk & @carlsbergfondet.dk

Hookworms: Can parasites improve your health? Normal Curves: Sexy Science, Serious Statistics · Episode

So happy to see hookworms being discussed here!
#immunosky #hooworms #parasitosky

open.spotify.com/episode/1U8U...

Blood of man who’s had 200 snake bites helps make a potent antivenom Treatment combines existing drug with antibodies from hyper-immune reptile collector, raising both hopes and ethical concerns.

🩸🐍 Hyper-immune antivenom from 200+ snake bites

A new antivenom made with antibodies from Tim Friede – a man bitten by snakes 200 times – protects mice from 19 deadly species.

🔗 doi.org/10.1038/d415...

#SciComm #Snakes #Immunology 🧪

Really sad I can't make it this year, as its at the same time as IFPA (placenta conference) - but would recommend for any macrophage fans #macrophage #bestcell #sorryi'llmissit

Screenshot of deadly complications of measles.

Almost 600 cases of measles in Ontario.

Welcome back to the dark ages, where dead kids is just the cost of doing business.

There is a Postdoc job available in my lab to study fundamental mechanisms of antiviral immunity, specifically in the context of viral nucleic acid sensing. Please take a look here and contact me if interested:
#immunosky #virology 🧪
www.jobs.cam.ac.uk/job/50254/

First post on Bluesky, let’s share some websites offering many free illustrations for scientific figures 🖼️ 🧪 🌍 :

scidraw.io

bioart.niaid.nih.gov

www.phylopic.org

More well known but very nice though: www.freepik.com

#immunosky Check out this fantastic postdoc position available in Seth’s group working on gdT cells in breast cancer metastasis at University of Glasgow and please share with potential applicants👇🏻

IL-4 induces CD22 expression to restrain the effector program of virtual memory T cells CD22 regulates IL-4–induced expansion and responsiveness of virtual memory T cells during helminth infection.

Super happy to share our new study now published in #Science #Immunology - www.science.org/doi/10.1126/.... Congrats to first author Bin Yang✨. #IL-4 expand Virtual Memory T cells (TVM) which 'borrow' the normally B-cell restricted CD22 for regulating their activation during #helminth infection.

Our February issue is now live! This week: CD22 restrains #IL4 -driven #TVMcell expansion during #helminth infection; molecular determinants of #TCR x-reactivity against #influenza variants; & #MultipleMyeloma breakout lesions are tumor–immune interaction hotspots!

science.org/toc/sciimmunol/10/104

@bendewals.bsky.social

Excellent review summarizing the current status of alarmins as therapeutic targets in asthma:
www.jacionline.org/article/S009...
#immunosky
#medsky
#immunology
#🧪

Mgl2+ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation in mice Nature Communications - Fungal spores can promote immune responses of both type 2 (IL-4 / IL-5 / IL-13) and type 17 (IL-17). Here the authors characterise the subsets of cDC2 associated with type 2...

Delighted to see our study on #DendriticCell control of #fungal #allergic airway #inflammation finally out in the wild! Spearheaded by @drpetercook.bsky.social, with so many fantastic collaborators - thanks to all! #ImmunoSky 🧪
rdcu.be/d68MU @lydiabeckeriii.bsky.social @edinburgh-uni.bsky.social

The science behind how sickness shapes your mood | Keely Muscatell TED Health · Episode

Interesting episode on the connection between immunology and stress. For the lay person 🫡✌🏻
#immunology #stress #mentalhealth
open.spotify.com/episode/5Jrw...

RELMβ sets the threshold for microbiome-dependent oral tolerance - Nature RELMβ mediates a gut immune–epithelial circuit regulating tolerance to food antigens, offering targetable candidates for the prevention and treatment of food allergies.

Excess intestinal protein RELMβ linked to food allergies in children through effects on the microbiome. Blocking RELMβ could prevent allergies by restoring gut microbiome balance. Potential for targeted therapies and time for more human studies.
www.nature.com/articles/s41...

Interleukin-6 is significantly increased in severe pneumonia after allo-HSCT and might induce lung injury via IL-6/sIL-6R/JAK1/STAT3 pathway Interleukin-6 elevated in severe pneumonia after allo-HSCT and plays a role in lung injury via the IL-6/sIL-6R/JAK1/STAT3 pathway.

Not that we need it per se, but a little bit more evidence that IL-6 can drive pathological inflammation in lungs...
(here in mouse model of post allo-HSCT)
@jidjournal.bsky.social
#immunosky #medsky

📢 Abstract submissions for the #EARA2025 Conference, 'Shaping the future of animal research communication,' are now open!

✍️ Find out more about how to submit your abstract: eara.eu/post/eara-co...

#AnimalResearch #EARA #SciComm

Heart has its own ‘brain’ – zebrafish study The heart has its own nervous system to control the heartbeat, according to a study in zebrafish, which may provide new insights into treating cardiovascular diseases.Researchers at the Karolinska Ins...

🫀 The heart has its own nervous system to control the heartbeat, according to a study in zebrafish at
@karolinskainst.bsky.social @columbiauniversity.bsky.social, which may provide new insights into treating #CardiovascularDiseases.
#AnimalResearch
www.eara.eu/post/heart-h...

First mouse strain that can naturally get severe Covid-19 US researchers are hopeful that research on Covid-19 can be greatly improved, using an existing strain of lab mouse that is highly susceptible to the disease.Laboratory mice used in Covid-19 studies m...

🐁 Researchers at EARA member @jacksonlab.bsky.social have identified a strain of lab mouse that is naturally susceptible to severe #Covid19.

🦠 The CAST/EiJ mouse holds the potential to improve study & treatment of future variants. #AnimalResearch
www.eara.eu/post/first-m...

German researchers raise concerns on latest animal use statistics Newly published statistics on the use of animals in research for 2023 in Germany show both a significant short and long-term decline in animal numbers.The total number of animals used was 1,456,562, a drop of 16% from 2022 (1,725,855), and in comparison to pre-Covid (2019) figures the total number has fallen by more than a quarter (27%).In its press release TVV, the German animal research advocacy organisation, noted that the efforts to reduce animal testing are clearly bearing fruit, but the ra

🇩🇪 The 2023 #AnimalResearch statistics in Germany show both a significant short & long-term decline in numbers.

📉 Tierversuche verstehen noted in its report that the rate of decline partly reflects the increasingly difficult conditions for research in Germany.
www.eara.eu/post/german-...

Detecting brain tumours in mice with 'molecular flashlight' An ultra-thin light probe that reaches deep into the brain could provide a non-invasive way to detect chemical changes caused by tumours or brain injuries, following research in mice.The study, by the Spanish National Cancer Research Centre (CNIO) and the Spanish National Research Council (CSIC), and also involving EARA member the University of Padua, Italy, developed a probe, less than one-millimetre wide, that projects a thin beam of light.This ‘molecular flashlight’, was successfully inserted

🔦 An ultra-thin light probe that reaches deep into the brain could provide a non-invasive way to detect chemical changes caused by #BrainTumours or brain injuries, in a
@cniostopcancer.bsky.social @csic.es study in #mice.
#AnimalResearch
www.eara.eu/post/detecti...

EARA news round-up: December 2024 YouTube video by The European Animal Research Association (EARA)

📹 For the last #EARA news round-up of 2024, check out December's highlights in #AnimalResearch!
youtu.be/2cAc5Q_tl7s

🎉 We are pleased to announce that the Karolinska Institute
@karolinskainst.bsky.social has joined #EARA!

The KI is one of the world’s foremost medical universities & marks our second member institution in Sweden.

Check out our full list of members: eara.eu/our-members

We are pleased to announce that the European Animal Research Association has become a member of AAALAC International!

This is an important partner for EARA as AAALAC seeks to promote openness and transparency in the use of animals in research to a global audience. #EARA

Sensors for improved bone injury recovery in rats Tiny implantable sensors that can transmit real-time data about how bone injuries are healing could improve recovery, according to a US study in rats.After injury, resistance training with exercise is an effective form of rehabilitation to aid healing, however it can be difficult to identify the exact type and intensity of exercise that is best suited to each individual.A team led by the University of Oregon (UO), which developed the sensors, implanted the devices into rats with thigh bone injur

🦴 Tiny implantable sensors that can transmit real-time data about how #BoneInjuries are healing could improve recovery, according to a @uoregon.bsky.social study in #rats.

🐀 The sensors showed that injured rats had improved bone healing from resistance training.
www.eara.eu/post/sensors...

✍️ A reminder that abstract submissions for the first-ever #EARA Conference (6-7 Nov in Berlin) are OPEN!

🗣️ This is a key opportunity to present research/projects/initiatives related to #AnimalResearch comms & transparency!

👉 wheldonevents.co.uk/online-regis...

#EARA2025

Let's Talk SciComm - Roman Stilling & Johannes Beckers YouTube video by The European Animal Research Association (EARA)

🗣️ The latest episode of our #LetsTalkSciComm series features the Tierversuche verstehen podcast, Fabeln, Fell & Fakten (Fables, Fur & Facts).

👥 Check out what co-hosts @neuromancing.bsky.social
& Johannes Beckers had to say about communicating #AnimalResearch!
www.youtube.com/watch?v=THjV...