Biopsy-derived colonoid air-liquid interface monolayers reveal persistent mucosal defects in ulcerative colitis patients AbstractBackground. The inflammatory bowel disease (IBD) ulcerative colitis (UC) is characterized by colonic mucosal inflammation and barrier dysfunction.

🚨NEW FINDINGS! In the age of personalized medicine, we find that biopsy-derived organoids from ulcerative colitis patients show impaired mucus and epithelial barriers, mimicking patient pathologies and providing a platform to test new drugs to repair these barriers. academic.oup.com/ibdjournal/a...

Congratulations to all including two projects co-led by @bcchresearch.bsky.social’s @mklevings.bsky.social and @brucevallance.bsky.social

🎉🎉🎉🎉🎉

Fab work led by @brucevallance.bsky.social and @ctropini.bsky.social

@bcchresearch.bsky.social

How much does your gut health impact your overall health? A lot, doctors say | CBC News Doctors are tapping into to the emerging field of the gut microbiome to try to treat some diseases differently.

🚨 We’re featured in @CBCNews!
Our team is using organoids to study how microbes interact with the gut mucus layer, and how this relationship impacts diseases like IBD 💩🔬
📰 Read the full story: www.cbc.ca/news/health/...
#Microbiome #GutHealth #Organoids #IBD

Frontiers | Crosstalk with infant-derived Th17 cells, as well as exposure to IL-22 promotes maturation of intestinal epithelial cells in an enteroid model

Very grateful to be a part in this project now finally published. www.frontiersin.org/journals/imm...

@yanchen.bsky.social

Defining enteric bacterial pathogenesis using organoids: Citrobacter rodentium uses EspC, an atypical mucinolytic protease, to penetrate mouse colonic mucus Enteric bacterial pathogens pose significant threats to human health; however, the mechanisms by which they infect the mammalian gut in the face of daunting host defenses remain to be fully defined. F...

New paper from our lab! We developed an organoid-based air-liquid interface (ALI) model that produces physiologically relevant intestinal mucus and discovered that EspC has a mucinolytic superpower which enables C. rodentium to degrade mucus. 🧫🦠https://pmc.ncbi.nlm.nih.gov/articles/PMC12054374/