Nazlican Yürekli

scene from Rocketman the movie showing a very glamorous Elton John on the right in a car wearing a pink feathered costume (as a simile to a glycosylated protein) vs a normally dressed guy on the left, as a simile for a protein without the glycans. The meme is originally from @benschulz.bsky.social

If you are at #Pacifichem2025 I'll be opening the symposium of Advances in Glycan Structure and Dynamics [BIO004] at 9:15 am (sadly) from Southampton (UK) and not from Honolulu 😔, but I'll try to keep the #glycotime lively and cheerful even from afar 🤩👍

Very helpful package , and it’s free.. it’s good to not pay so much money to wormtrack softwares anymore:). Amazing service.

As a woman scientist, I can’t separate Crick’s genius from his harm. Nancy Hopkins, now at MIT, spoke in Picture a Scientist about his harassment. True progress in science demands empathy, accountability, gender equality and respect.

Professor Jochen Guck, Director at the Max Planck Institute for the Science of Light (MPL), He headed the division “Cell Physics” at MPL and the Max-Planck-Zentrum für Physik und Medizin (MPZPM).

With deep sadness, we share that Prof. Jochen Guck, Director at the Max Planck Institute for the Science of Light passed away on October 3. His visionary work bridged physics and medicine. We have lost a brilliant scientist and dear friend.

mpl.mpg.de/news/article...
@fau.de

📸 Stephan Spangenberg

Really enjoyed reading the preprint! One thing I’m curious about is since CRISPR targets phage (not bacterial) DNA, how does its benefit link to bacterial mutation supply?
Could that be indirect such as via bottlenecks or phage dynamics rather than mutation rate itself?

Lead by postdoc in the lab Ruiqi Ge and in collaboration with Bob Coffey’s lab, we are happy to share rPAL-seq for rapid and sensitive sequencing based profiling of glycoRNAs @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...

🍬🔬Proteins are so sweet under the microscope .. 🍬🔬

As Möckl RG, for the first time, we image the single-protein glycosylation in native cell state with super-resolution microscopy, map cell-surface glycoproteins, and uncover their spatial organization.

#MöckIRG
#glycotime
#glycoprotein
#dnapaint

So proud of my colleague & friend @dijo-mj.bsky.social for winning Best Poster Award at the 14th SMLM Symposium in Bonn 🎉👏 His creativity, dedication & hard work truly deserve this recognition. Grateful to be part of the work and Möckl RG!

#SMLMS2025 #superresolutionmicroscopy #glycotime

A fair semantic point. The term signifies breaking the 1-nm barrier, a symbolic milestone in bioimaging. While true atomic resolution is the goal, achieving ~9Ả allows us to measure critical inter-glycan distances for the first time, which is the core of @karimalmahayni.bsky.social 's advance.

Cell's sugar coating mapped at below-nanometre resolution Nature - Super-resolution technique works with off-the-shelf optical microscopes.

Scientists have mapped individual sugar molecules on the surface of cells at a resolution once thought to be impossible for light microscopes

go.nature.com/40I9Ewv

🚨 2 × PhD positions @EPFL! 🚨
Help us push the boundaries of fluorescence microscopy - DNA nanotech, custom optics & spatial omics in Lausanne 🇨🇭. Start Jan 2026. Send CV + motivation + 2 refs → fschueder@ethz.ch
#PhD #Hiring #microscopy #SuperResolution #SpatialOmics #DNAPAINT #FLASHPAINT

Ångström-resolution imaging of cell-surface glycans

Now published in Nature Nanotechnology! 🤩
@natnano.nature.com

www.nature.com/articles/s41...

Ever wondered what happens when therapeutic antibodies bind to cancer cells? In our latest study, we used multiplexed 3D-RESI to directly visualize how anti-CD20 antibodies interact with their receptors, revealing their precise arrangement at single-protein resolution. (1/6)

Very happy to see this one out - the first molecular-resolution imaging of glycocalyx components in their native environment! Great collaboration with @jungmannlab.bsky.social - congrats to first authors @karimalmahayni.bsky.social and @lumasullo.bsky.social and to the whole team!

Ångström-resolution imaging of cell-surface glycans - Nature Nanotechnology By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the native glycocalyx has been ...

New paper online:

Ångström-resolution imaging of cell-surface glycans.

The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.

#Glycotime

www.nature.com/articles/s41...

Nazlican is illuminating the complex landscape of the glycocalyx. Together with her colleague Dijo M. Joseph, she co-led their latest publication: Glycan Atlassing: Nanoscale analysis of glycocalyx architecture enables functional tracing of cell state.

👉 www.biorxiv.org/content/10.1...

Glycan Atlassing enables to track cell state by glycocalyx organization 🍬🍬

Our latest paper is available
👉🏼https://www.biorxiv.org/content/10.1101/2025.04.29.651200v1

#möcklrg #glycotime #glycocalyx #superresolution

Research Group Leonhard Möckl ›Physical Glycosciences‹ Natural killer cells (NK cells) are one of the essential components of the innate immune system. They recognize and eliminate diseased cells. NK cells do not have to be activated by other cells to kill a target, unlike their adaptive immune counterparts. This fast response requires their activity to be tightly regulated in the body. One mode of regulation might be glycan-protein interactions happening on the membranes of NK cells. Research in the Möckl group ›Physical Glycosciences‹ uses advanced optics to reveal the functional role of glycosylation in immune cell regulation.

Natural killer cells are key to the immune system, eliminating diseased cells. Their activity must be tightly controlled, possibly through glycan-protein interactions. Researchers use advanced optics to study how glycosylation regulates immune cells.

👉 mpl.mpg.de/research-at-...

📸 Nazlican Yürekli

Glycan Atlassing: Nanoscale analysis of glycocalyx architecture enables functional tracing of cell state The glycocalyx is a complex layer of glycosylated biomolecules surrounding all cells in the human body. It is involved in the regulation of critical cellular processes such as immune response modulation, cell adhesion, and host-pathogen interactions. Despite these insights, the functional relationship between glycocalyx architecture and cellular state has remained elusive so far, mainly attributable to the structural diversity of glycocalyx constituents and their nanoscale organization. Here, we show that DNA-tagged lectin labeling and metabolic oligosaccharide engineering enables multiplexed super-resolution microscopy of glycocalyx constituents, yielding an atlas of glycocalyx architecture with nanometer resolution. Quantitative analysis of the obtained nanoscale map of glycocalyx constituents facilitates the extraction of characteristic spatial relationships that accurately report on cellular state. We demonstrate the capacity of our approach, which we term Glycan Atlassing, across cell and tissue types, ranging from cultured cell lines to primary immune cells, neurons, and primary patient tissue. Glycan Atlassing establishes a powerful strategy for investigating glycocalyx remodeling in development and disease, potentially enabling the development of new glycocalyx-centered targets in diagnosis and therapy. ### Competing Interest Statement The authors have declared no competing interest. Else Kröner-Fresenius-StiftungElse Kröner-Fresenius-Stiftung, https://ror.org/03zcxha54, 2020_EKEA.91 Deutsche ForschungsgemeinschaftDeutsche Forschungsgemeinschaft, https://ror.org/018mejw64, 529257351, 460333672, 270949263 Wilhelm Sander StiftungWilhelm Sander Stiftung, https://ror.org/02q83sc19, 2023.025.1 European Research CouncilEuropean Research Council, , 101118729 Alexander von Humboldt FoundationAlexander von Humboldt Foundation, https://ror.org/012kf4317,

Check out this latest
#glycotime achievement from Leonhard Moeckl’s lab: single sugar superresolution imaging to create a high res glycan atlas of cell surfaces!

www.biorxiv.org/content/10.1...

Huge shoutout to @dijo-mj.bsky.social and @nazlicanyurekli.bsky.social who spearheaded this study! Also, thanks to our amazing collaborators Sarah Fritsche, Reem Hashem, Oana-Maria Thoma, Imen Larafa, Tina Boric, Chloe Bielawski, @karimalmahayni.bsky.social, Kristian Franze, and Maximilan Waldner!

“ 🍭🧫🔬Alice in sugar land 🔬🧫🍭”

So happy to be part of this amazing work. Let’s dive into the amazing organization and dynamics of glycocalyx in various of samples and be amazed how cell states can be traced by glycocalyx states🔬, of course, in super resolution level 😉.

#möcklgroup #glycotime

Our latest paper made the cover! 🎉

We developed a library of light-activated molecules designed for precise, localized induction of cell death in biological systems, characterized both in vitro and in vivo.

Great collaboration with @wehnerlab.bsky.social

Read more: pubs.acs.org/doi/full/10....

ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS🍬🍬🍬

For the first time, we are able to image the molecular architecture of the glycocalyx at Ångström resolution. A dream come true!

Read the preprint: biorxiv.org/content/10.110…

And find our tweetorial below!
#glycotime

Angstrom-resolution imaging of cell-surface glycans Glycobiology is rooted in the study of monosaccharides, Angstrom-sized molecules that are the building blocks of intricate glycosylation patterns. Glycosylated biomolecules form the glycocalyx, a dens...

This is an amazing achievement - angstrom scale imagine of glycan molecules, what a great time for #glycotime. Congrats Leonhard Möckl!

www.biorxiv.org/content/10.1...

ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🍬🍭🔬

For the first time, we’re able to study the molecular architecture of the glycocalyx at single-sugar resolution—a longstanding challenge in glycobiology! #glycotime

Preprint and #bluetorial below!!