Busquets-Garcia Lab's Avatar

Busquets-Garcia Lab

@bgarcialab

We are located in the Barcelona Biomedical Research Park. We want to better understand cell-type specific mechanisms underlying brain physiology and pathology.

195
Followers
264
Following
40
Posts
02.01.2025
Joined
Posts Following

Latest posts by Busquets-Garcia Lab @bgarcialab

Preview
Mitochondrial Ca2+ efflux controls neuronal metabolism and long-term memory across species - Nature Metabolism Boosting mitochondrial metabolism in neurons in central memory circuits by enhancing Ca2+ retention in the mitochondrial matrix is shown to improve long-term memory formation in flies and mice.

You invite somebody to give a talk at @researchmar.bsky.social. You had an amazing conversation during lunch. You start a collaboration. A postdoc @carlarduaso.bsky.social got nice results. You end up in an amazing paper. Congrats @jdejuan-sanz.bsky.social et al.!!

www.nature.com/articles/s42...

11.02.2026 11:42 πŸ‘ 8 πŸ” 1 πŸ’¬ 0 πŸ“Œ 1

Wishing you all a great and happy 2026! πŸ₯³

31.12.2025 17:27 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Post image Post image

We did our Christmas lunch remembering the good and bad achievements of 2025. Celebrating one's and learning from the others. 2026 will be another exciting year for us. Very happy of the Christmas present I have received from my lab!! Proud PI :)

18.12.2025 15:46 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

It was a pleasure to present some of our Lab projects on social cognition in the @neuroalc.bsky.social . I am very happy for the nice discussion at the end of the talk and also for the opportunity to learn from really exciting projects that are being developed in this neuroscience institute.

12.12.2025 19:53 πŸ‘ 3 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

We would also like to thank @remi-pr.bsky.social for his great support along this project helping us in our first steps analyzing behavioral and photometry data with computational tools.

04.12.2025 21:05 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Preview
Dorsal hippocampus mediates light–tone associations in male mice A light–tone sensory preconditioning task in male mice is developed revealing sex differences and demonstrating that dorsal, but not ventral, hippocampal CaMKII-positive neurons encode innocuous stimu...

After a constructive and extensive revision, happy to share our manuscript published in @elife.bsky.social entitled "Dorsal hippocampus mediates light–tone associations in male mice" (doi.org/10.7554/eLif...). Congrats to Julia Pinho, @carlarduaso.bsky.social and @imanzanaressierra.bsky.social.

04.12.2025 21:05 πŸ‘ 10 πŸ” 5 πŸ’¬ 3 πŸ“Œ 0

This year we will be presenting two oral talks on Friday 28th November:
@imanzanaressierra.bsky.social
with the talk "MODELING CANNABIS-INDUCED PSYCHOTIC-LIKE STATES IN MICE" and
@carlarduaso.bsky.social
with "ASTROGLIAL LIPID METABOLISM: A LINK BETWEEN CANNABINOID DRUGS AND ALZHEIMER DISEASE?".

27.11.2025 09:37 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Heading to another #SEIC2025 meeting in Madrid to celebrate the 25 years of this great, inspiring and constructive meeting on the cannabinoid-related research in Spain. Some of my best scientific memories come from this meeting.

27.11.2025 09:32 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Today, during the first meeting of the psychoneuroimmunology society held in Granada, our PhD student Irene Ferreres will be presenting our latest findings on the impact of adolescent stress on kynurenine metabolism in microglia and astrocytes.

πŸ“ Poster 20 | πŸ•š 11:00–13:00

14.11.2025 07:39 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Preview
Obesogenic diet impairs memory consolidation via the hippocampal endocannabinoid system Although obesogenic high-fat/high-sugar diets impair memory function in humans and rodents, the underlying mechanisms remain elusive. Given that the b…

πŸŽ‰ Happy to share the latest work published in @CurrentBiology from the Guillaume Ferreira lab where I collaborated! A big congrats to Guillaume and all people involved πŸ‘

Check it out here: www.sciencedirect.com/science/arti...

13.11.2025 17:30 πŸ‘ 3 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0
Post image

When you start your lab, nobody has taught you how to supervise or overcome multiple difficulties of a PhD. I am happy that today the first PhD from my lab was well defended. Congrats Laura! Many thanks to @carlessaura.bsky.social , Ester Aso and @miriammelis.bsky.social for an inspiring discussion.

15.10.2025 13:46 πŸ‘ 7 πŸ” 0 πŸ’¬ 0 πŸ“Œ 1

Tomorrow, I will be in Zaragoza participating to a new edition of the Research Career Course organized by the @academiajoven.bsky.social . During this course we will discuss about research funding, evaluation, dissemination, ethics, emotional management, among other important topics.

.

25.09.2025 21:05 πŸ‘ 2 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

In addition, I will be giving a talk in an interesting symposium organized by @carmensandi10.bsky.social explaining some ongoing projects of the lab regarding the behavioral effects of cannabinoid drugs.

17.09.2025 15:23 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

We are at @eurbehavpharm.bsky.social meeting ⛡️ Tomorrow @imanzanaressierra.bsky.social (Post. #1.7) and @carlarduaso.bsky.social (Post. #1.34) are presenting posters regarding the link between Cannabinoid drugs and Psychosis and Cannabinoid drugs and Alzheimer Disease, respectively.

17.09.2025 14:45 πŸ‘ 3 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0

Together with Giovanni Marsicano, @bolanosjuanp.bsky.social and @imanzanaressierra.bsky.social, we took profit of the #SENC2025 to have an exciting meeting with interesting findings from our @caixaresearch.bsky.social project, in which we are investigating the psychotic effects of cannabis.

06.09.2025 10:51 πŸ‘ 3 πŸ” 2 πŸ’¬ 0 πŸ“Œ 0

Tomorrow, our PhD student
Irene Ferreres
will be presenting the poster "Impact of adolescent stress on behaviour
and neuroimmune function" (num. 116). Come to see our posters and discuss our research.

03.09.2025 08:29 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

oday, our PhD student
@imanzanaressierra.bsky.social
will be presenting the poster entitled "Studying the psychotic-like states induced
by Delta-9-Tetrahidrocannabinol (THC):
new behavioral strategies to tackle the
complexity of psychosis in mouse models" (num. 305)

03.09.2025 08:29 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

Our group is in the #senc2025 meeting in Gran Canaria where we will show two different stories from the lab through the presentation of two posters.

03.09.2025 08:29 πŸ‘ 3 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

This study suggest that data-driven analysis reveals nuances missed by traditional measures to measure mouse behavior representing a step toward richer, data-driven profiling of mouse behavior.

28.08.2025 21:06 πŸ‘ 0 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

The main findings are briefly summarized here:

➑️ Indirect associated cues through second-order conditioning triggers distinct behavioral responses compared to cues directly associated with reinforcer.

➑️ Older mice struggle with second-order conditioning

28.08.2025 21:06 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0

We developed a pipeline combining DeepLabCut, Keypoint-MoSeq & DeepOF to study age- and sex-dependent differences in light-tone second-order conditioning in mice.

28.08.2025 21:06 πŸ‘ 0 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Preview
Profiling mouse behavior with computational tools to assess age-dependent differences in associative learning Canela et al. introduce a data-driven pipeline to dissect second-order conditioning (SOC) behavioral responses in mice. Their work reveals that SOC elicits unique behavioral signatures depending on th...

🚨 New paper from our lab published in @cp-cellrepmethods.bsky.social and performed in the @researchmar.bsky.social led by our PhD student
Marc Canela.

πŸ“„More info below:
www.cell.com/cell-reports...

28.08.2025 21:06 πŸ‘ 4 πŸ” 2 πŸ’¬ 1 πŸ“Œ 0

Our contribution, led by our postdoc @carlarduaso.bsky.social, has been to infuse MitoDREADD in the hippocampus of APP/PS1 mice, a mouse model of amyloidosis accompanied by cognitive decline, and show how the enhancement of mitochondrial activity reverse memory deficits in this mouse model.

12.08.2025 06:11 πŸ‘ 1 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
Preview
Potentiation of mitochondrial function by mitoDREADD-Gs reverses pharmacological and neurodegenerative cognitive impairment in mice - Nature Neuroscience Activation of Gs signaling at mitochondria by mitoDREADD-Gs increases mitochondrial metabolism, leading to better memory in mouse models of dementia, directly linking brain mitochondrial deficits to c...

Our group is proud to have contributed to a new paper published in @nature.com
led by @marsicano.bsky.social, in which MitoDREADD, a new tool to enhance mitochondrial activity, show promising effects against the cognitive decline in neurodegenerative disorders.

www.nature.com/articles/s41...

12.08.2025 06:11 πŸ‘ 4 πŸ” 1 πŸ’¬ 1 πŸ“Œ 1

Very happy and honored that our ERASE project has been proposed to be funded by the @ageinves.bsky.social . 3 exciting years ahead to further investigate the brain substrates of emotion recognition in normal and pathological aging. #PID2024

29.07.2025 19:43 πŸ‘ 8 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

The wildfire touching Marseille prevented me to be in the symposium, to share our project linking astrocytes, cannabinoid drugs and Alzheimer disease and to attend to the interesting @gliameeting.bsky.social ! I am sure the symposium conducted by @murphyroyallab.org has been a success!

08.07.2025 15:22 πŸ‘ 1 πŸ” 0 πŸ’¬ 0 πŸ“Œ 0

Together with Ciaran @murphyroyallab.org, from the UniversitΓ© de Montreal, we are co-chairing today the Symposium "Understanding the roles of astrocytes in cognition and behaviour across the lifespan" in the @gliameeting.bsky.social in Marseille.

08.07.2025 09:33 πŸ‘ 4 πŸ” 0 πŸ’¬ 0 πŸ“Œ 2
Post image

Recycle your poster, share your research! New #Neuroscience event at @researchmar.bsky.social

πŸ—“οΈ July 24 ⏰15:15h πŸ“Marie Curie Room
πŸ‘©β€πŸ”¬ Keynote by Dr. Sara Mederos (@sainsburywellcome.bsky.social)

πŸ”— Register: forms.office.com/Pages/Respon...

πŸ‘‰ researchmar.net/agenda/968

@bgarcialab.bsky.social

07.07.2025 09:18 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
Post image

🧠 How does the brain make decisions based on indirect associations between stimuli?

πŸ”¬ A new @pnas.org study led by Dr. Busquets @bgarcialab.bsky.social (@researchmar.bsky.social)
sheds light on the role of the amygdala and cortical circuits

πŸ‘‰ researchmar.net/news/732/

@hospitaldelmar.bsky.social

27.06.2025 08:27 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Our postdoc @carlarduaso.bsky.social will show her postdoctoral results during the Poster session during the morning of Sunday 29th. (P1.7): Astrocytes in action: sex-, genotype-, and cannabinoid-dependent mechanisms in Alzheimer’s Disease.

28.06.2025 05:04 πŸ‘ 4 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0