Welcome Danny to our campus! Looking forward to interacting more and having you around!
02.03.2026 18:52
👍 10
🔁 1
💬 0
📌 0
One more week to finalize your applications for the 2026 MBL zebrafish course at Woods Hole!
Application deadline extended to March 9.
Please repost and forward to anyone interested in learning 'everything zebrafish'!
www.mbl.edu/education/ad...
01.03.2026 12:06
👍 8
🔁 6
💬 0
📌 1
Just published: chemotactic sperm cells become phototactic 💡- by loading photo-activatable second messengers. This allows to "reverse-engineer" chemotactic signaling dynamics and expose cells to signals they would never see in the wild. Honoured to be part of this collaboration with the Kaupp lab.
26.02.2026 09:18
👍 69
🔁 18
💬 2
📌 3
Interested in expanding your zebrafish skills or completely new to zebrafish as model system for your research question? Then this course is for YOU!
Deadline for applying is on March 2nd, so get your applications in.
PS: It's a fantastic course - changed my own career!
www.mbl.edu/education/ad...
25.02.2026 19:00
👍 4
🔁 1
💬 0
📌 2
Keynote speakers:
- Elly Tanaka (@imbavienna.bsky.social)
- Pavel Tomancak (@mpi-cbg.de)
All other speakers will be selected based on submitted abstracts.
We are looking forward to welcoming you for exciting science in the heart of Vienna, with a special dinner at the Vienna City Hall!
23.02.2026 20:06
👍 1
🔁 0
💬 0
📌 0
Join us in Vienna for the biggest international 'FISH' meeting in 2026! No matter which fish is your favorite model - zebrafish, medaka, killifish, cavefish, Danionella, cichlids, stickleback, you name them...- this meeting is for you!
www.ezm2026.org
Abstract submission deadline is March 15th.
23.02.2026 20:06
👍 27
🔁 16
💬 3
📌 3
How does the piRNA pathway solve the self vs. non-self problem? 🧬
Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)
13.02.2026 15:11
👍 90
🔁 51
💬 2
📌 4
Registration is OPEN for the 2026 Santa Cruz Meeting on Developmental Biology!!! #scdb26
@flybase.bsky.social @zfinmod.bsky.social @alliancegenome.bsky.social @insdb.bsky.social @isdb.bsky.social @geneticssociety.bsky.social @bsdb.bsky.social @ascbiology.bsky.social
scdb2026.sites.ucsc.edu
19.02.2026 17:47
👍 15
🔁 10
💬 0
📌 2
Switching fields or wanting to become an expert in #zebrafish research?
The @mblscience.bsky.social 2026 Zebrafish Development & Genetics course offers a fantastic opportunity to learn from leaders in the field!
Application deadline: March 2
Please spread the word!
www.mbl.edu/education/ad...
11.02.2026 20:22
👍 28
🔁 30
💬 0
📌 4
Thinking about EZM2026 in Vienna? 🐟
Travel grants are now open for students & ECRs.
7–11 July 2026 | Deadline: March 15
Hope to see many of you there! @ezsociety.bsky.social #zebrafish
06.02.2026 10:19
👍 11
🔁 10
💬 0
📌 0
Mark your calendars for 2027! The best GRC is coming to Europe 🇳🇱
💥 Fertilization and Activation of Development
📍 Noordwijk, Netherlands
🗓️ July 31 - August 6, 2027
www.grc.org/fertilizatio...
Can’t wait!
25.01.2026 19:56
👍 12
🔁 3
💬 0
📌 1
In vivo kinetics of protein degradation by individual proteasomes
Protein degradation by the proteasome is central to cellular homeostasis and has been studied extensively using biochemical and structural studies. Despite an in-depth understanding of core proteolytic activity, it has remained largely unresolved how individual proteasomes process substrates inside living cells where many substrate types and co-factors exist. Here, we establish a live-cell single-molecule imaging approach that enables direct visualization and quantification of protein degradation by individual proteasomes. Using this approach, we find that substrate identity, folding and protein-protein interaction have a surprisingly modest impact on processing efficiency, whereas the mode of substrate engagement greatly impacts substrate processing; degradation initiated from protein termini typically proceeds rapidly and with high processivity, whereas internal engagement constitutes a distinct processing mode that exhibits poor processivity and a specific requirement for the AAA+ family ATPase p97/VCP. Furthermore, degradation initiated from opposite termini proceeds with asymmetric rates in a sequence-dependent manner, demonstrating that directionality is an important feature of proteasomal processing in vivo. Notably, poly-glutamine substrates associated with neurodegenerative disease are efficiently degraded from one terminus but resist degradation when engaged from the opposite terminus, highlighting the importance of substrate engagement mode. Together, our results show that different modes of substrate engagement lead to different proteasomal processing outcomes in vivo and revise the prevailing view of the proteasome as a uniform degradation machine. ### Competing Interest Statement The authors have declared no competing interest.
New lab paper!! We develop a technology for real-time, single-molecule visualization of proteasomal substrate degradation in cells. We find that the site of substrate engagement by the proteasome determines decay kinetics, efficiency and co-factor requirement.
www.biorxiv.org/content/10.6...
20.01.2026 08:32
👍 47
🔁 15
💬 1
📌 2
🧪Scientists from our Haselbach lab captured how proteins begin to fold as they’re being made.
Using cryo-EM, they visualised chaperones guiding nascent proteins on the ribosome: https://www.nature.com/articles/s41467-025-67685-6
19.01.2026 09:40
👍 51
🔁 16
💬 1
📌 1
If you are interested in #ubiquitin related topics (Who isn’t???) & looking for a friendly and collegial meeting where you can talk to anyone & everyone, this is your meeting!
10.01.2026 11:54
👍 19
🔁 4
💬 0
📌 0
If you want to become an expert in #zebrafish research, apply for the 2026 Zebrafish Development & Genetics course! You will be working in small groups taught by leaders in the field, which can be a transformative experience!
Application deadline: March 2
www.mbl.edu/education/ad...
03.01.2026 09:01
👍 8
🔁 7
💬 0
📌 1
Course Offerings | Marine Biological Laboratory
Are you planning your summer ahead and are interested in immersing yourself in some intense weeks of research, science and fun?
Then this might be for you: Check out the amazing summer course offerings @mblscience.bsky.social, including the #Zebrafish course!
www.mbl.edu/education/ad...
03.01.2026 09:01
👍 9
🔁 3
💬 1
📌 0
Applications for the 2026 Vienna BioCenter Summer School Program are now open!
Please share this opportunity with talented undergrads or Masters students interested in broadening their research experience in molecular biology in the heart of Europe 🧬
17.11.2025 16:48
👍 10
🔁 8
💬 0
📌 0
Very happy to share my postdoc work (on preprint), where we try to understand a long-standing transcription-silencing paradox, and uncovered a hidden RNA decay arm of nuclear piRNA pathway, see detailed threads quoted from @juliusbrennecke.bsky.social
22.12.2025 19:38
👍 33
🔁 12
💬 1
📌 0
We probably shouldn’t have favourites amongst projects in the lab, but this one was mine. I’m so pleased we can finally share it:
Our work is now out in Nature Communications:
🔗 nature.com/articles/s41467-025-67692-7
22.12.2025 14:38
👍 25
🔁 10
💬 2
📌 1
I feel like a parent seeing your first kid leave home ;-).
While the entire Pauli lab family will greatly miss @lorenzoorts.bsky.social as Laura has become a real role model, it makes me incredibly happy & proud to have her establish the Lorenzo-Orts lab at the @imbmainz.bsky.social! All the best!
14.12.2025 20:26
👍 41
🔁 3
💬 1
📌 0
Systematic analysis of noncanonical ribosomal protein paralogs does not provide evidence for specialized functions in Drosophila
So excited to finally be able to share my first paper and the culmination of my PhD work with @felipekteixeira.bsky.social 🪰🔬
www.pnas.org/doi/10.1073/...
04.12.2025 21:41
👍 15
🔁 12
💬 3
📌 2
All the best for becoming the 'Schierleader' yourself for your team! Rooting for you, and am looking forward to seeing what the Reimao Pinto-lab will be up to in the future!
03.12.2025 07:03
👍 2
🔁 0
💬 1
📌 0
Big congrats to the entire team from the @beckmannlab.bsky.social and @greenlab.bsky.social, in particular first author Vienna!
23.11.2025 20:52
👍 2
🔁 1
💬 0
📌 0
How does the kinase ZAK sense ribosome collisions? Find out in our latest collaboration with the @greenlab.bsky.social @doubleshuang.bsky.social @Vienna Huso: 1/4
rdcu.be/eRmJl
#ribosome #cryoEM #LMU #JHMI
23.11.2025 15:46
👍 49
🔁 20
💬 2
📌 2
SAVE THE DATE! Stoked to organize the 2026 Santa Cruz Developmental Biology Meeting with @rashmi-priya.bsky.social, @lowelab.bsky.social, and Shelbi Russell. Come learn about Biomedicine, Biomechanics, and the Biosphere, August 24-28, 2026. Registration dates, etc., coming soon! Please RT
19.11.2025 20:23
👍 119
🔁 75
💬 1
📌 3
How does messenger RNA (mRNA) get out of the nucleus to become a protein? Eukaryotic mRNA is packaged, exported, and then translated in the cytoplasm. But how do these steps work? And what are open questions? Check out our new review for our take: www.annualreviews.org/content/jour... (1/3)
21.11.2025 17:36
👍 122
🔁 52
💬 1
📌 3
