Ailith Ewing

New insights into high grade serous ovarian cancer tumour evolution | Institute of Genetics and Cancer | Institute of Genetics and Cancer A study led by researchers at the Institute of Genetics and Cancer has gained new insights into how high grade serous ovarian cancer tumours emerge and grow, opening new avenues to develop better trea...

A study led by @ailithewing.bsky.social has gained new insights into how high grade serous ovarian cancer tumours emerge and grow, opening new avenues to develop better treatments: edin.ac/40vjn9a
@natcomms.nature.com @cmvm-edinburghuni.bsky.social

Impact of BRCA mutations, age, surgical indication, and hormone status on the molecular phenotype of the human Fallopian tube - Nature Communications The human Fallopian tube (FT) is implicated as a site of origin for pelvic serous cancers. Here the authors conduct multi-omics analysis on over 100 FTs. The results challenge the assumption that BRCA...

Surprising findings of BRCA mutations on the Fallopian tubes. Result of a tremendous team effort with @shenhui1986.bsky.social @vainstitute.bsky.social, Chuck Drescher @fredhutch.bsky.social, and Jarrod Marto @danafarber.bsky.social.
@pennmedcso.bsky.social
www.nature.com/articles/s41...

Low-coverage whole genome sequencing of low-grade dysplasia strongly predicts advanced neoplasia risk in ulcerative colitis Background The risk of developing advanced neoplasia (AN; colorectal cancer and/or high-grade dysplasia) in ulcerative colitis (UC) patients with a low-grade dysplasia (LGD) lesion is variable and dif...

Delighted our work using aneuploidy as a biomarker of colorectal cancer risk in inflammatory bowel disease is out: gut.bmj.com/content/earl...

The initial reaction from patients&families has been overwhelming

Led by Ibrahim AlBakir @yosoykit.bsky.social @cancerresearchuk.org @icrlondon.bsky.social

Genetic background sets the trajectory of cancer evolution Human cancers are heterogeneous. Their genomes evolve from genetically diverse germlines in complex and dynamic environments, including exposure to potential carcinogens. This heterogeneity of humans,...

🌟NEW PREPRINT ALERT!🌟

We are very pleased to introduce #StrainDifferences: “Genetic background sets the trajectory of cancer evolution”

www.biorxiv.org/content/10.1...

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We have an open #PhD #studentship as part of our "Black Leaders in Cancer" programme at @crukconvergence.bsky.social & @icrlondon.bsky.social. About computational modelling of T-cell evolution in cancer. www.findaphd.com/phds/project... I'm looking forward to meeting prospective students #CRUKfunded

Well done Dr Jan! A PhD student with @mstaylor.bsky.social who passed his viva yesterday. We’ll miss having the indel expert in the building!
📷 artistic credit to Martin

Normal breast tissues harbour rare populations of aneuploid epithelial cells - Nature Using single-cell DNA sequencing we show that most healthy women harbour rare populations of aneuploid epithelial cells with copy number alteration events in their breast tissue that expand and accumu...

new out in Nature www.nature.com/articles/s41...

Chromothripsis in cancer - Nature Reviews Cancer Chromothripsis is an extreme form of chromosome instability that causes the acquisition of multiple genomic aberrations. Simovic-Lorenz and Ernst discuss mechanistic models of chromothripsis and outli...

www.nature.com/articles/s41... #instability #evolution #cancer

People working on the causes or consequences of #aneuploidy or #CIN.
Reply if I missed you and you want adding to the list

go.bsky.app/G8wHoXx

Coordinated inheritance of extrachromosomal DNAs in cancer cells - Nature Cooperative species of extrachromosomal DNAs are coordinately inherited through mitotic co-segregation.

Cancer cells often harbor oncogenes outside chromosomes on extrachromosomal DNA (ecDNA), which is unevenly inherited by dividing cells. We reported in Nature last week that collectives of ecDNAs are inherited together by dividing cancer cells. 1/
www.nature.com/articles/s41...

Automated real-world data integration improves cancer outcome prediction - Nature A study generates a clinicogenomics dataset resource, MSK-CHORD, that combines natural language processing-derived clinical annotations with patient medical data from various sources to improve m...

Huge resource of MSK-IMPACT "genomes", what a treasure trove! Automated real-world data integration improves cancer outcome prediction www.nature.com/articles/s41...

We are happy to announce the release of a new #nf-core workflow -- #oncoanalyser performs an exhaustive analysis of single-patient cancer sequencing data using methods developed by the Hartwig Medical Foundation Australia. (1/5)

Tune in today at 2pm UK time for an online seminar explaining why our lab cares about Chromosomal Instability in cancer - as part of a wonderful lecture series on CIN