[6/6] Full roadmap, both preprints, and stakeholder consultation docs here: onlygoodantibodies.co.uk/roadmap/
09.03.2026 09:18
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[6/6] Full roadmap, both preprints, and stakeholder consultation docs here: onlygoodantibodies.co.uk/roadmap/
[5/6] And we've built the tools: a searchable database (147 genes), free e-learning (5 modules + certification), and the Antibody Champions programme with NC3Rs. No excuses left.
[4/6] So we ran a Delphi study. 32 experts from Abcam, CST, eLife, Nature Protocols, MJFF, NC3Rs, and leading universities. 15 consensus recommendations. Every stakeholder group has a job to do.
[3/6] Global extrapolation: 4–7 million animal samples, 6–11 million human tissue samples consumed using antibodies that would fail independent testing. And those are conservative estimates.
[2/6] 97 antibodies failed all applications when tested with knockout controls. We traced them through 760 papers. 84% had zero validation evidence. 8,064 animal samples. 4,424 human tissue samples. Consumed without any evidence the antibodies worked. 📄
[1/6] Two new preprints out today from the OGA team. We've quantified the ethical costs of poor antibody validation for the first time — and developed a consensus plan to fix it. Thread 🧵
Want to drive real change in research quality and reduce unnecessary animal use?
Are you an early career researcher ready to develop leadership skills while making research more impactful for patients?
Join us as an Antibody Champion!
In Lifecycle Journal's publish-before-review model, research is published before undergoing evaluation. Published submissions are eligible for review by services including @oga-community.bsky.social, a nonprofit that evaluates research that relies on antibodies:
lifecyclejournal.org/evaluation-s...
We're very pleased to publicly announce the winners of the 2025 Dorothy Bishop Prize, which celebrates the contributions of early career researchers working to promote #OpenResearch and improve #ResearchCulture.
Congratulations to:
- Annayah Prosser
- Michael Biddle
- Lewis Jones
#AcademicSky
Congratulations Michael Biddle for winning the @ukrepro.bsky.social Dorothy Bishop award for your contributions to #Open and #Reproducible research culture. We are so proud of all of the excellent work you have been leading!
Congratulations Michael Biddle for your nomination for this award recognising contributions to #Open , #Reproducible , and generally better research!
www.ukrn.org/2025/03/04/d...
We’re pleased to join the UK Reproducibility Network (@ukrepro.bsky.social) as a stakeholder in support of a more open, transparent and reproducible research culture. Find out more:
@aledmedwards.bsky.social has been working on this problem for a long time. He is part of the @ycharos.bsky.social leadership
This rate of validation suggests that antibodies should be considered non-specific until proven otherwise:
357 validated out of 1,124 tested.
.
www.ukrn.org/2025/01/28/u...
🚨 Just over 24 hours left for PhD applications to be submitted to join our DTP
📅 Midday (GMT) TOMORROW Friday 10 Jan
The application form and all details are on our website more.bham.ac.uk/mrc-aim/phd-... as well as a helpful FAQ doc and two Zoom recordings from recently held information sessions
📣Check out "A Consensus Platform for Antibody Validation," which describes YCharOS's knockout cell-line based antibody validation platform. 📣
www.nature.com/artic...
Better antibodies, Better science, Better patient outcomes. Visit us to find out more!
onlygoodantibodies.com/projects/
Learn more about us and our collaboration with @ycharos.bsky.social in this @nature.com feature by Diana Kwon.
www.nature.com/articles/d41...
The @ycharos.bsky.social antibody characterization protocol using knock-out cells as controls is now published, and endorsed. Remember though that it’s a generic protocol - you still need to do the proper controls for your own experiments! www.nature.com/articles/s41...
