Michael Fischbach

Cool germinal center acrobatics from Juhee Pae et al, check it out!

www.nature.com/articles/s41...

This pair of papers demonstrating strong and systemic immune responses to skin commensals applied topically to unbroken skin, including induction of B cells for vaccination.
www.nature.com/articles/s41...
www.nature.com/articles/s41...

These are my favorites too! 🤯

What an amazing story that was such a blast to collaborate on with @mfgrp.bsky.social lab!!! Phenomenal work led by @djenetbousbaine.bsky.social and all co-authors!! Unroll this thread and be amazed 🤯👇🏾

Scientists turned a harmless skin bacterium into a powerful vaccine delivery tool, boosting immunity in the lungs and nose.

@mfgrp.bsky.social @djenetbousbaine.bsky.social @nature.com

t.co/xXXCJx5VYm
#ImmunoSky 🧪

A typical project for an incoming graduate student might involve 1–2 weeks of planning and 2–5 years of execution, [yet] the problem you choose will influence the impact of your work just as much as the quality of your execution. @mfgrp.bsky.social
open.spotify.com/episode/6KMh...

Stanford Scientists Transform Ubiquitous Skin Bacterium into a Topical Vaccine Against Tetanus Even better, it’s cheap, entirely pain-free, no need to stand in a line, and not followed by fever, swelling, redness, or a sore arm.

Insanely creative and original immunology and bioengineering work from the Fischbach Lab at Stanford with high translational potential

Full article in NATURE: www.nature.com/articles/s41...

Follow the scientists:

@mfgrp.bsky.social
@djenetbousbaine.bsky.social
@katebauman.bsky.social

Beautiful work with exciting implications for topical vaccination by @mfgrp.bsky.social ✨

Give this a read 👇

Vaccines, but make it skincare!🧴🧬 Congratulations to Stanford BioE Professor Michael Fischbach @mfgrp.bsky.social & @djenetbousbaine.bsky.social for engineering a skin bacterium that could lead to needle-free vaccines.

Check out our last pub. from @mfgrp.bsky.social al lab! We discovered that skin commensal microbes induce systemic and local B cell responses upon colonization and took advantage of this knowledge to create topical vaccines using engineered skin microbes. Please read the thread for details.

Your hand lotion is now also a vaccine. Hot damn

Two fascinating papers just out in Nature @natureportfolio.bsky.social:
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Illuminating thread by author ‪@mfgrp.bsky.social

bsky.app/profile/mfgr...

Brilliant work congrats to the authors!

Awesome thread from @mfgrp.bsky.social about what might be the most amazing result you'll hear about in 2024: antigens stuck on the surface of the skin bacterium S. epidermidis generate a strong immune response in mouse.

A remarkable story from @mfgrp.bsky.social and colleagues: immunization via skin S. epidermidis generates systemic and mucosal antibody responses.

And in a Nature publication double-header, @mfgrp.bsky.social @stanford-chemh.bsky.social collaborates with Yasmine Belkaid and workers in this study reporting on local immune response including antibody generation in response to skin commensals:

www.nature.com/articles/s41...

This is the most amazing thread since they did a similar thing to cure a cancer

Wonder.
Awe.
Excitement.
Very cool thread on a very cool finding.

#IDSky

Holy shit this is amazing!!! 🤯

discovery that a skin microbe can, without inflammation, induce a systemic B-cell response... and then engineering that microbe into a potent vaccine platform that can be applied as a topical cream. amazing work from @djenetbousbaine.bsky.social and @mfgrp.bsky.social! www.nature.com/articles/s41...

An amazing discovery, and a very informative and engaging thread. Could develop into a transformative new mode for efficient vaccination

one to savor over the holidays. also so cool to see how the directions of the work between @mfgrp.bsky.social and Belkaid labs diverged.

Brilliant 🧵on a fascinating study demonstrating potent systemic and mucosal antibody responses to the common skin commensal Staph. epidermidis. Engineered S. epi expressing or displaying unrelated antigens elicited protective immunity,suggesting it could serve as topical vaccines. 💉

Co-opting a skin commensal to design new vaccines! An amazingly creative and thoughtful new approach that integrates our knowledge of immune system responses. #ImmunoSky

Check out this bombshell publication by Michael Fischbach @mfgrp.bsky.social and coworkers @stanford-chemh.bsky.social @stanfordmedicine.bsky.social, imagine a cancer immune therapy/vaccine where treatment begins and ends with a painless topical skin treatment! 🤯

www.nature.com/articles/s41...

Finally, we are deeply grateful to Mark Leslie, @dpessential.bsky.social, Solina Chau, and Marc Benioff for supporting this work via the Microbiome Therapies Initiative. 55/55

We couldn't have done this without generous financial support from Open Philanthropy, @gatesfoundation.bsky.social, @helmsleytrust.bsky.social, @su2c.bsky.social, @czbiohub.bsky.social, and NIH, and incredible institutional support from @stanford-chemh.bsky.social, IMA, and Stanford BioE. 54/55

Christina Tobin Kåhrström and our referees were kind and constructive. Our paper was greatly improved by their suggestions. 🙏 53/55

Stanford scientists transform ubiquitous skin bacterium into a topical vaccine Stanford University scientists’ findings in mice could translate into a radical, needle-free vaccination approach that would also eliminate reactions including fever, swelling and pain.

A few notes of gratitude. First, many thanks to @brucegoldman for explaining this so clearly... 52/55
med.stanford.edu/news/all-new...