Jon Lim, FRCP PhD's Avatar

Jon Lim, FRCP PhD

@drjonlim

Senior Lecturer & Consultant Medical Oncologist in Advanced #Immunotherapy + #CellTherapy at @manchester.ac.uk & The Christie โ€ข RISE Lead & MANIFEST Deputy Lead โ€ข ESMO #TranslationalResearch Faculty ๐Ÿ”— Bio: bit.ly/Christie_JLim (tennis enthusiast ๐ŸŽพ)

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Latest posts by Jon Lim, FRCP PhD @drjonlim

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Do you have an impactful research idea?
One that could improve care or advance science?

Apply for the ESMO Leadership & Career Development Award, offering protected research time, leadership & communication training by 3 May 26 .

๐Ÿ”—https://ow.ly/Gicm50YqcbZ

#Oncology #ESMOYOC

06.03.2026 17:01 ๐Ÿ‘ 3 ๐Ÿ” 4 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

The Crick Postdoctoral Clinical Fellowship has been one of the most pivotal steps in my development as a clinical academic.

The environment, mentorship, infrastructure, and scientific ambition at @crick.ac.uk are truly unparalleled.

Strongly recommended! Deadline: 30th April ๐Ÿ‘‡

04.03.2026 01:48 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
Emerging Leaders | Emerging Leaders - British Journal of Cancer BJCโ€™s Emerging Leaders collection recognises stand-out early-to-mid career researchers, clinicians, and educators within the field of oncology.

Grateful to ๐˜‰๐˜ณ ๐˜‘ ๐˜Š๐˜ข๐˜ฏ๐˜ค๐˜ฆ๐˜ณ for the kind feature in their ๐—˜๐—บ๐—ฒ๐—ฟ๐—ด๐—ถ๐—ป๐—ด ๐—Ÿ๐—ฒ๐—ฎ๐—ฑ๐—ฒ๐—ฟ๐˜€ collection. Thank you to the editors for the nomination ๐Ÿ™.

Like many things, this really reflects teamwork & collaboration with many generous colleagues. Our perspective on TIL therapy in melanoma is now out #OpenAccess ๐Ÿ‘‡

25.02.2026 07:06 ๐Ÿ‘ 4 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
Man in a dark blue patterned shirt leaning on a window ledge inside a bright, modern corridor with large windows.

Man in a dark blue patterned shirt leaning on a window ledge inside a bright, modern corridor with large windows.

Professor Ludwig Dubois joins the MCRC & @manchester.ac.uk @fbmh-uom.bsky.social
as Chair in Experimental & Translational Radiobiology.

Heโ€™ll spearhead research into proton beam therapy & FLASH treatments to improve patient outcomes.

Read more: https://ow.ly/1k5g50YkUEn

25.02.2026 07:00 ๐Ÿ‘ 2 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Tumour-infiltrating lymphocyte therapy in melanoma: ready for prime time? - British Journal of Cancer British Journal of Cancer - Tumour-infiltrating lymphocyte therapy in melanoma: ready for prime time?

Our new perspective just out in ๐˜‰๐˜ณ๐˜ช ๐˜‘ ๐˜Š๐˜ข๐˜ฏ๐˜ค๐˜ฆ๐˜ณ on TIL therapy in melanoma.

As TIL move closer to real-world use, the ๐˜ฉ๐˜ฐ๐˜ธ matters as much as the ๐˜ธ๐˜ฉ๐˜ฆ๐˜ต๐˜ฉ๐˜ฆ๐˜ณ. We reflect on the near future & the practical challenges of moving from trials to routine care.

Keen to hear thoughts/experiences from others๐Ÿ‘‡

19.02.2026 09:18 ๐Ÿ‘ 2 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Come and join us at the ESMO Preceptorship on CUP! @worldcupalliance.bsky.social spread the word!

17.02.2026 18:47 ๐Ÿ‘ 7 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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๐ŸŽ“ New PhD Opportunity

An exciting PhD opportunity at the Cancer Research UK Manchester Centre, supporting the next generation of leaders in cancer research.

๐Ÿ“… Deadline: Friday 3 April
๐Ÿ”— For further information & to apply: ow.ly/ZWYs50Y7vHR

@uom-dcs.bsky.social
@manchester.ac.uk

07.02.2026 15:49 ๐Ÿ‘ 2 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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๐Ÿ‘‰...cutting-edge science, clinical insights & discussions re: real-world implementation of TIL therapy.

Featuring keynote speakers:
Inge Marie Svane ๐Ÿ‡ฉ๐Ÿ‡ฐ & Sebastian Klobuch ๐Ÿ‡ณ๐Ÿ‡ฑ.

@sklobuch.bsky.social
@debrajosephs.bsky.social
@turajliclab.bsky.social
@beckilee.bsky.social

03.02.2026 14:49 ๐Ÿ‘ 3 ๐Ÿ” 3 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Unlocking TIL Therapy: A New Era for Melanoma Care in the UK TIL (Tumour-Infiltrating Lymphocyte) therapy is a transformative, cell-based immunotherapy approach now entering clinical practice for melanoma. This national summit brings together UK and internation...

๐Ÿ“ฃ Final agenda confirmed - only 5 weeks to go!

Join us on ๐Ÿญ๐Ÿญ ๐— ๐—ฎ๐—ฟ๐—ฐ๐—ต ๐Ÿฎ๐Ÿฌ๐Ÿฎ๐Ÿฒ in Manchester ๐Ÿ for our inaugural TIL Summit: Unlocking TIL Therapy โ€“ A New Era for Melanoma Care in the UK.

Kindly sponsored by The Christie Charity.

Space limited - so don't miss out! For further information & to register:

03.02.2026 14:49 ๐Ÿ‘ 5 ๐Ÿ” 4 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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The beginning of an international partnership between The Christie and the National Cancer Institute of Ukraine The Christie Institute for Cancer Education has welcomed international colleagues from the National Cancer Institute of Ukraine (UNCI) as part of a new education partnership focused on bilateral shari...

One of the projects Iโ€™m most proud of since returning to Manchester.

In awe of the resilience of our Ukrainian colleagues delivering cancer care under extraordinary circumstances, and grateful for the generosity of #TeamManchester colleagues in sharing best practice.

๐Ÿ‡ฌ๐Ÿ‡ง ๐Ÿค ๐Ÿ‡บ๐Ÿ‡ฆ

Find out more ๐Ÿ‘‡

02.02.2026 14:51 ๐Ÿ‘ 2 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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New Journal for ImmunoTherapy of Cancer review: Steroid-sparing strategies for managing immune-related adverse events jitc.bmj.com/content/14/1...

26.01.2026 14:41 ๐Ÿ‘ 2 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
lab to life

lab to life

Exciting conference alert!

sites.manchester.ac.uk/from-lab-to-...

Fantastic speakers includingย Chris Marine, Christian Blank

Melanoma evolution
Local microenvironment of melanoma
Melanoma-host interactions
Precision immunotherapy
Emerging therapeutics
Clinical trials and real-world data

22.01.2026 23:28 ๐Ÿ‘ 5 ๐Ÿ” 5 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

๐Ÿ”— For further details (deadline 3 June 2026):
www.esmo.org/meeting-cale...

22.01.2026 17:14 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 1
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๐Ÿ†• New on the ESMO events calendar for 2026!

Mark your calendar for the ๐—˜๐—ฆ๐— ๐—ข ๐—ฃ๐—ฟ๐—ฒ๐—ฐ๐—ฒ๐—ฝ๐˜๐—ผ๐—ฟ๐˜€๐—ต๐—ถ๐—ฝ ๐—ผ๐—ป ๐—ง๐˜‚๐—บ๐—ผ๐˜‚๐—ฟ-๐—”๐—ด๐—ป๐—ผ๐˜€๐˜๐—ถ๐—ฐ ๐—–๐—ฎ๐—ป๐—ฐ๐—ฒ๐—ฟ๐˜€ ๐—ฎ๐—ป๐—ฑ ๐—–๐—ฎ๐—ป๐—ฐ๐—ฒ๐—ฟ ๐—ผ๐—ณ ๐—จ๐—ป๐—ธ๐—ป๐—ผ๐˜„๐—ป ๐—ฃ๐—ฟ๐—ถ๐—บ๐—ฎ๐—ฟ๐˜† (๐—–๐—จ๐—ฃ) in Zurich: 18-19 September 2026.

Chaired by the fantastic @oncocook.bsky.social & @benwestphalen.bsky.social.

@myesmo.bsky.social

22.01.2026 17:14 ๐Ÿ‘ 3 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 1

This is one of the projects Iโ€™m most proud of since coming back to (re-)join #TeamManchester faculty. Delighted to welcome and host our Medical Oncology colleagues from UNCI, Kyiv at The Christie.

๐Ÿ‡บ๐Ÿ‡ฆ ๐Ÿค ๐Ÿ‡ฌ๐Ÿ‡ง

18.01.2026 17:39 ๐Ÿ‘ 5 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Youโ€™re such an inspiration, Adam! Keep going ๐Ÿ™Œ.

17.01.2026 13:30 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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๐Ÿš€ Kicking off the new year with our next #ChristieFellowship session!

How do we communicate science well - to patients, the public, and on social media?

Join us for an interactive session on ๐—ฃ๐˜‚๐—ฏ๐—น๐—ถ๐—ฐ ๐—–๐—ผ๐—บ๐—บ๐˜‚๐—ป๐—ถ๐—ฐ๐—ฎ๐˜๐—ถ๐—ผ๐—ป with Prof @achoud72.bsky.social.

@christieinstitute.bsky.social
@mcrcnews.bsky.social

15.01.2026 21:12 ๐Ÿ‘ 5 ๐Ÿ” 3 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Thanks to @acir-org.bsky.social for highlighting our article!

14.01.2026 17:43 ๐Ÿ‘ 9 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

Really grateful to you, Evangelos! Your mentorship, guidance and friendship in the lab made a huge difference, especially early on as a new PhD fellow ๐Ÿค“.

Looking forward to continuing to work closely together in Manchester! ๐Ÿ™Œ

@uom-dcs.bsky.social
@mcrcnews.bsky.social
@cruk-mi.bsky.social

15.01.2026 09:14 ๐Ÿ‘ 4 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

โ—Cross-presentation shapes neoantigen visibility and cancer immunogenicity in #NatureImmunology๐Ÿคฏ
www.nature.com/articles/s41...
Huge congratulations @drjonlim.bsky.social ๐Ÿฅ‚
Inspired and so lucky to have you in #Manchester ๐Ÿ
Congratulations to #OliverSchulz, @reisesousalab.bsky.social , @crick.ac.uk

14.01.2026 22:27 ๐Ÿ‘ 9 ๐Ÿ” 2 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
Client Challenge

NB 'An important function of the immune system is to eradicate pre-malignant and malignant cells in the early phase of tumor development. For this reason, the use of carcinogens rather than transplantable tumor cell lines in mice can offer a more refined experimental approach (...)'

14.01.2026 08:40 ๐Ÿ‘ 3 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

...and follow this thread ๐Ÿงต for how the story evolved:

14.01.2026 16:40 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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DC cross-presentation of dead cell F-actin antigens sculpts tumor evolution Lim, Schulz, et al. studied the functioning of the F-actin receptor DNGR-1 on cDC1s, and the impact of cross-presentation on immunoediting of tumors using chemical carcinogenesis models. Dead cell-ass...

How does the immune system decide which tumour antigens remain visible over timeโ“

Our study on dendritic cell cross-presentation of dead-cell, F-actinโ€“associated antigens, and its impact on tumour immunogenicity and cancer evolution, was featured in @acir-org.bsky.social.

Read further here ๐Ÿ‘‡

14.01.2026 14:53 ๐Ÿ‘ 9 ๐Ÿ” 1 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
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๐Ÿค” Do patients with cancer and clinicians see disease status the same way?

Our study highlights where understanding aligns - and where it doesnโ€™t - underscoring the importance of clear communication in palliative care.

Presented first at #ESMOGI24, now published in full:
doi.org/10.1007/s003...

13.01.2026 17:46 ๐Ÿ‘ 3 ๐Ÿ” 0 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0
Translational Research Programme Manager :Paterson Building As an equal opportunities employer we welcome applicants from all sections of the community regardless of age, sex, gender (or gender identity), ethnicity, disability, sexual orientation and transgender status. All appointments are made on merit.

๐Ÿšจ NEW opportunity! ๐Ÿšจ

Weโ€™re recruiting a Translational Research Programme Manager to support delivery of the recently launched MRC-funded ๐—ฅ๐—œ๐—ฆ๐—˜ programme at @uom-dcs.bsky.social @manchester.ac.uk - based in the Withington campus.

๐Ÿ—“๏ธ Deadline: 30th January 2026.

๐Ÿ”— To find out more and to apply:

12.01.2026 17:49 ๐Ÿ‘ 1 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0

We cover:
โ€ข TCR-T, CAR-T, TIL & NK-cell approaches
โ€ข Lessons from early clinical studies
โ€ข Key biological & practical challenges
โ€ข Where the field may be heading next

Will cell therapy work in sarcomaโ“

#Sarcoma #CellTherapy #CancerImmunotherapy #TranslationalResearch

12.01.2026 17:28 ๐Ÿ‘ 0 ๐Ÿ” 0 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Cell therapy in sarcoma: current landscape and future directions Sarcomas are rare malignancies of mesenchymal origin, characterized by significant biological and clinical heterogeneity. Many subtypes demonstrate limited sensitivity to standard systemic treatments,...

๐Ÿงฌ Cell therapy in sarcoma: what do we know so far?

Our new #OpenAccess review in the ๐˜‘ ๐˜๐˜ฎ๐˜ฎ๐˜ถ๐˜ฏ๐˜ฐ๐˜ต๐˜ฉ๐˜ฆ๐˜ณ ๐˜Š๐˜ข๐˜ฏ๐˜ค๐˜ฆ๐˜ณ @sitcancer.bsky.social summarises the current landscape of cell therapy in sarcoma.

@tkoraysahin.bsky.social @lizconnolly.bsky.social

12.01.2026 17:28 ๐Ÿ‘ 4 ๐Ÿ” 3 ๐Ÿ’ฌ 1 ๐Ÿ“Œ 0

A big welcome to our #MedicalOncology colleagues from National Cancer Institute of Ukraine ๐Ÿ‡บ๐Ÿ‡ฆ. Looking forward to working with you all this week and beyond!

@mcrcnews.bsky.social
@christieinstitute.bsky.social

12.01.2026 09:11 ๐Ÿ‘ 5 ๐Ÿ” 4 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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How Dying Tumor Cells Alert the Immune System To Fight Cancer New research shows how dendritic cells sound the alarm in response to dead cancer cells.

As featured in Technology Networks ๐Ÿ‘‡

www.technologynetworks.com/tn/news/how-...

06.01.2026 17:33 ๐Ÿ‘ 5 ๐Ÿ” 1 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0
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Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity - Nature Immunology Here the authors show DNGR-1 expressed by cDC1s promotes CD8โบ T cell priming to cytoskeletal neoantigens from dying tumor cells, thereby shaping cancer immune visibility and tumor evolution through im...

Congrats to the team of @reisesousalab.bsky.social for this beautiful work in @natimmunol.nature.com showing that "Neoantigen cross-presentation by cDC1 can determine the immune visibility of the tumor mutational landscape and sculpt cancer evolution by immunoediting"

www.nature.com/articles/s41...

06.01.2026 12:51 ๐Ÿ‘ 4 ๐Ÿ” 2 ๐Ÿ’ฌ 0 ๐Ÿ“Œ 0