Sarah Borrie

A systems immunology analysis of Alzheimer's disease reveals an age‐ and environmental exposure‐independent disturbance in B cell maturation INTRODUCTION Alzheimer's disease is a severe neurodegenerative disorder, with multifactorial mechanisms of disease development and progression. Evidence from genetic association studies, animal mode...

Our new study on #systemsimmunology analysis of #Alzheimers patients is out now at @alzdemjournals.bsky.social!

This is the culmination of a collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8

alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

‼️Lymphatic Education&Research Network-GRC Scholarships‼️

LE&RN is awarding 10 × $1,000 scholarships to early investigators to attend 2026 Lymphatics GRC March 1 – March 6, 2026, Lucca (Barga), Italy.

🗓 Apply by Dec 8, 2025!

form.jotform.com/LERN/2026-gr...

Cool neurogenesis meeting in the Swiss Alps!!

'Neurogenesis from development to adulthood in health and disease'

To submit an application: asconameeting@unige.ch

Taking fusion cuisine to the next level....they should leave the spätzle alone😉

UK Glia 2026 UK Glia 2026 meeting will highlight the pivotal role of glia in brain physiology, offering invaluable insights for those investigating glia function in both health and disease. Find out more about the...

📢 June 8th-9th 2026 Bristol University 📢

We have partnered with @physoc.bsky.social to organise the 2nd meeting Bristol. It is a privilege to announce Professor Baljit Khakh, FRS will join us in the UK.

Check out the exciting programme here:
www.physoc.org/events/uk-gl...

#neuroskyence #glia

Share this funding opportunity! We offer the Fellows-to-Faculty program to nurture new talent in the basic sciences and to broaden the community of scientists contributing to Simons Foundation Autism Research Initiative (SFARI) and Simons Collaboration on Plasticity and the Aging Brain (SCPAB).

Stained axons

@andreaserio.bsky.social and I are recruiting a postdoc to lead an exciting MNDA-funded project using multi-omics to study long axons in motor neurons and how they shape susceptibility to #ALS.

Get in touch for any questions and apply by 2 December:
my.corehr.com/pls/kclrecru...

Screenshot of the top of the article, including the title, authors, and abstract.

What’s better than a one-channel #Miniscope? 🥁 A TWO-CHANNEL Miniscope!

Our new Miniscope2C is a dual-channel, open-source Miniscope that lets you record 2 fluorescent signals simultaneously in freely moving animals.

Read the paper here: www.science.org/doi/10.1126/...

(1/10)

Delighted to speak at the @microgliaseries.bsky.social on Monday. Everyone welcome to join us online 🧬✨

Neuroimmune mechanisms of neurodevelopmental disorders Neurodevelopmental disorders (NDDs) are characterized by alterations in typical brain development. The immune system is increasingly implicated in NDDs and may contribute to both susceptibility and pa...

Anderson and colleagues review studies demonstrating that neuroimmune mechanisms play a critical role in both healthy neurodevelopment and the pathology of neurodevelopmental disorders.

Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures Lish et al. present a co-culture system of iPSC-derived human microglia, astrocytes, and neurons to investigate intercellular communication across different environmental and genetic contexts. Transcr...

New TYP lab publication led by PhD student @alexlish.bsky.social out today in @cp-cellreports.bsky.social! We present a reproducible neuron-astrocyte-microglia tri-culture model to better reproduce intercellular interactions in Alzheimer's disease. Read more here: www.cell.com/cell-reports...

CSF1R ligands promote microglial proliferation but are not the sole regulators of developmental microglial proliferation Summary: In vitro and in vivo investigations indicate that CSF1 and IL34 may partially regulate the developmental proliferation of microglia in the mouse hippocampus and cortex, but an additional laye...

Just out, recent work from the Plemel lab by the talented Brady Hammond. We sought to understand the factors that regulate microglial proliferation during development.
journals.biologists.com/dev/article/...

Research Fellow: Immunity in Alzheimer’s Disease Postdoc role at UK DRI–UCL exploring how Alzheimer’s risk genes affect microglial function and antigen presentation using cutting-edge models and techniques.

Postdoc role in the De Strooper / Arancibia Lab in the UK DRI–UCL exploring how Alzheimer’s risk genes affect microglial function and antigen presentation using cutting-edge models and techniques. Closing date: 27th July. @ukdri.ac.uk

www.dementiaresearcher.nihr.ac.uk/job/research...

URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯

Any lab using @flybase.bsky.social please donate using the link in post below.

This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice CAR T cell therapy can cause cognitive impairment in mouse models with central nervous system (CNS) and non-CNS cancers by inducing persistent neuroinflammation, thereby disrupting oligodendroglial homeostasis and hippocampal neurogenesis, which can be rescued by microglial depletion or CCR3 blockade.

Now online! Immunotherapy-related cognitive impairment after CAR T cell therapy in mice

Hey @jacksonlab.bsky.social
& neurotwitter, Have you had issues with this amyloidosis mouse line: B6.Cg-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax,
Stock No: 005864. Only 30% of 11 month old Heterozygous Tg mice show plaques???

⬇️This is happening today⬇️
See you all there!

Science Media SAVVY Our flagship media training increases confidence and skills to help researchers to engage more effectively with the wider public through broadcast, print and social media. Apply below. We create a uni...

Attention South Island-based experts looking for media training!

There are still a handful of spots in our 5-6 June Chch workshop (including at least one fees-free space).

We've extended the deadline to apply, and applications this week are likely to be accepted.

smc.nz/science-media-savvy/#apply

Redefining CNS immune privilege - Nature Reviews Immunology In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...

Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems.

@jonykipnis.bsky.social
www.nature.com/articles/s41...

CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density Lish et al. reveal that AD-protective CLU alleles enhance CLU upregulation in response to accumulated neuropathology, thereby dampening inflammatory signaling between microglia and astrocytes. Using s...

New TYP lab paper out today in @cp-neuron.bsky.social led by PhD student @alexlish.bsky.social! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read!
www.cell.com/neuron/abstr...

Excited for this meeting ! Please share and pass the word

OK here it is, the moment you have all been waiting for! Our advert for 5 posts here at Glasgow: Cognitive neuroscience/psychology. Closing date May 12 - please spread the word
www.nature.com/naturecareer...

As much as I’ve loved so many of the #StandUpForScience signs, this one is my favourite (but what else would you expect from Ms Macrophage).

Epigenetics

Exciting new role for a Computational Genomics Research Associate in the lab of @sj-marzi.bsky.social at the UK DRI at King's!

Lead projects exploring the epigenome and transcriptome of brain cells in neurodegenerative diseases 🧠

🗓️ Deadline: 08 March 2025
Full info & to apply 👉 shorturl.at/fk7jS

There is no ‘amyloid cabal’ in Alzheimer’s research “There exists no ‘amyloid cabal’” in Alzheimer’s research, neurologist Dennis Selkoe writes in response to Charles Piller’s “Doctored.”

Many Alzheimer’s researchers are also unhappy with Piller’s recent book and its negative characterization of the field, in which he inflates the significance of isolated fraud cases to argue that the entire field is corrupt. Here’s a rebuttal from my colleague Dennis Selkoe, published in STAT News:

If you want to learn about Charlie Piller's journalistic integrity, read this (long) thread.

bsky.app/profile/jere...

It is pretty telling...sensationalism without regard to getting the facts right.

We Are Recruiting Group Leaders - IBDM | Institut de Biologie du Développement de Marseille The Institut de Biologie du Développement de Marseille (IBDM) is inviting applications for group leader positions. We are seeking innovative researchers who aim to address fundamental questions in bio...

Multiple group leader positions in developmental biology in @ibdm.bsky.social Marseille, at an institute that produces some great work.

The importance of delivering Recherche d'Avenir – research for the future In recent years, several European countries, including France, have reduced their investment in scientific research, with biomedical research taking a significant hit. The primary casualty is basic re...

In her Essay, Renata Basto highlights the huge budget cuts facing the scientific community in France. In response to the cuts, a group of researchers has formed the ‘Pour une Recherche d'Avenir’ initiative to secure the future of French research.
journals.biologists.com/jcs/article/...

Eugenics, statistical hubris, and unknowable unknowns in human genetics A new paper just out in Nature , by Peter Visscher and colleagues (including bio-ethicist Julian Salvulescu) explores the idea of polygenic...

Eugenics, statistical hubris, and unknowable unknowns in human genetics www.wiringthebrain.com/2025/01/euge... - my response to a paper proposing editing the genomes of human embryos

PM Luxon "hoped universities would focus on building commercial revenue streams by selling intellectual property". Great, so now things are only valued if they are patentable. FFS. There is no vision or understanding for how science actually contributes to society