Patrick Lennard πŸ¦ πŸ”¬'s Avatar

Patrick Lennard πŸ¦ πŸ”¬

@prlennard

PhD | New πŸ’Š for #AMR | Tasmanian πŸ‡¦πŸ‡Ί |

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29.09.2023
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Latest posts by Patrick Lennard πŸ¦ πŸ”¬ @prlennard

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All private member's bills are equal, but some are more equal than others | Region Canberra While everyone was having a listen to and a laugh at Barnaby Joyce over his push to repeal net-zero laws,…

Mr Wilkie’s bill proposes changes to the social security law relating to oversight of automated decision-making, requiring manual oversight of such decisions at Services Australia. region.com.au/all-private-...

28.08.2025 03:24 πŸ‘ 79 πŸ” 29 πŸ’¬ 1 πŸ“Œ 2
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12.08.2025 11:59 πŸ‘ 6 πŸ” 3 πŸ’¬ 0 πŸ“Œ 0
Colonel Chestbridge holding a sword, jonesing for a drink
"And of course as always, Kill Hitler"

Colonel Chestbridge holding a sword, jonesing for a drink "And of course as always, Kill Hitler"

Viewers of this title recommended

04.02.2025 20:34 πŸ‘ 242 πŸ” 31 πŸ’¬ 4 πŸ“Œ 3
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They'll just let anyone into the ivory tower these days... #graduation #phd #newdoctor

09.07.2025 23:07 πŸ‘ 4 πŸ” 0 πŸ’¬ 1 πŸ“Œ 0
List of the names of the 231 Palestinian, 3 Lebanese and 2 Israeli journalists killed covering Israel's genocide of Gaza since 7 Oct 2023

List of the names of the 231 Palestinian, 3 Lebanese and 2 Israeli journalists killed covering Israel's genocide of Gaza since 7 Oct 2023

Of course, journalists in LA should not be targeted by police with rubber bullets. But let's not ignore the real issue of journalist safety

11.06.2025 05:21 πŸ‘ 414 πŸ” 221 πŸ’¬ 10 πŸ“Œ 6

Immediately after Israel comes 2nd in Eurovision, BBC News comes on, and the first story is footage of Israel bombing Gaza and killing children

Someone please tell me how this is real life?

πŸ˜” free Palestine πŸ‡΅πŸ‡Έ

#Eurovision #Politics #Palestine #Israhell

17.05.2025 23:22 πŸ‘ 760 πŸ” 153 πŸ’¬ 16 πŸ“Œ 9
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Donate to Support Belinda to study her Masters in One Health, organized by Belinda Omino Support Belinda to study a Masters in Infectious disease and One Heal… Belinda Omino needs your support for Support Belinda to study her Masters in One Health

www.gofundme.com/f/support-be...

16.05.2025 10:54 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Unfortunately due to grant funding, full scholarships aren't available for her intake. She's been an absolute star and was so determined to get into this, but is now left without a scholarship. Every contribution helps her get closer to a programme that changed my life 🌎

16.05.2025 10:54 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
Infectious Diseases and One Health (IDOH) is a 2-year full time ERASMUS Mundus Joint Master Degree. Mobility includes France (Tours), Spain (Barcelona) and Germany (Hannover).

My friend Belinda has been graciously accepted into the Erasmus Mundus Infectious Disease and One Health Master's programme (www.infectious-diseases-one-health.eu) that I had the luck to be a part of 😊

16.05.2025 10:54 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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Donate to Support Belinda to study her Masters in One Health, organized by Belinda Omino Support Belinda to study a Masters in Infectious disease and One Heal… Belinda Omino needs your support for Support Belinda to study her Masters in One Health

www.gofundme.com/f/support-be...

16.05.2025 10:54 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

Unfortunately due to grant funding, full scholarships aren't available for her intake. She's been an absolute star and was so determined to get into this, but is now left without a scholarship. Every contribution helps her get closer to a programme that changed my life 🌎

16.05.2025 10:54 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
Infectious Diseases and One Health (IDOH) is a 2-year full time ERASMUS Mundus Joint Master Degree. Mobility includes France (Tours), Spain (Barcelona) and Germany (Hannover).

My friend Belinda has been graciously accepted into the Erasmus Mundus Infectious Disease and One Health Master's programme (www.infectious-diseases-one-health.eu) that I had the luck to be a part of 😊

16.05.2025 10:54 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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SAAP-148 and halicin exhibit synergistic antimicrobial activity against antimicrobial-resistant bacteria in skin but not airway epithelial culture models AbstractBackground. The escalating global threat of antimicrobial resistance (AMR) necessitates the development of novel antimicrobial agents, innovative s

SAAP-148 is protective against colonisation by #AMR bacteria in skin and lung tissue models and synergises with the repurposed antibiotic halicin
doi.org/10.1093/jaca...
@prlennard.bsky.social #JACAMRNews #IDSky

07.05.2025 10:02 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0
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SAAP-148 and halicin exhibit synergistic antimicrobial activity against antimicrobial-resistant bacteria in skin but not airway epithelial culture models AbstractBackground. The escalating global threat of antimicrobial resistance (AMR) necessitates the development of novel antimicrobial agents, innovative s

πŸ”— TL;DR: New paper, new antibiotic combinations, new doctor πŸŽ“ For all the juicy details, check out the full study here: doi.org/10.1093/jaca... #OpenAccess #ScienceTwitter #MedicalResearch #InfectiousDiseases #OneHealth #Microbiology @bsacandjac.bsky.social

16.04.2025 21:49 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

πŸ‘ This work doesn’t happen in a vacuum: thanks to my principal supervisor Julia Dorin, and all my friends and colleagues at the LUMC, both in the Infectious Diseases department and the Leiden PulmoScience Lab

16.04.2025 21:49 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

🀝 Together, this work adds to the growing evidence base for advancing SAAP-148, other HDPs, and halicin for antibacterial therapy against AMR strains, both in combination and sequential therapy #AntibioticAlternatives

16.04.2025 21:49 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

πŸ’‘ When assessing the combination of preventative SAAP-148 and post-infection halicin treatment in these cultures, I also found that SAAP-148 and halicin only acted synergistically in skin but not in lung tissue (still beneficial though!) #CombinationTherapy #SequentialTreatment

16.04.2025 21:49 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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πŸ”¬ I expanded on this: instead using SAAP-148 as a preventative against AMR bacteria, applied in both HSEs and lung tissue cultures (PBECs). SAAP-148's activity was limited in PBECs against AMR bacteria, while active in HSEs due to the peptide being retained in cells

16.04.2025 21:49 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

☝ However, our team showed that SAAP-148 was effective against AMR bacteria in the dish, and also when infecting skin cultures (HSEs). Also, combining SAAP-148 with halicin (a repurposed antibacterial) was synergistic against AMR bacteria. Read it: www.mdpi.com/2079-6382/11... #SynergisticTherapy

16.04.2025 21:49 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

πŸ” Few studies specifically investigate synergy between host defence peptides (HDPs), like SAAP-148, and conventional antibiotics. Even then, many don’t clarify this effects between agents, or assess them in more dimensional models. Reviewed here: www.mdpi.com/2079-6382/12...

16.04.2025 21:49 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
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Happy to announce another published thesis chapter, now available in JAC-Antimicrobial Resistance! πŸŽ‰It features work from 3D cultures of skin and lung tissue as models of infection with #AMR bacteria, and therapy with the antimicrobial peptide SAAP-148 #AntimicrobialResistance @jac-amr.bsky.social

16.04.2025 21:49 πŸ‘ 6 πŸ” 2 πŸ’¬ 2 πŸ“Œ 0
Preview
SAAP-148 and halicin exhibit synergistic antimicrobial activity against antimicrobial-resistant bacteria in skin but not airway epithelial culture models AbstractBackground. The escalating global threat of antimicrobial resistance (AMR) necessitates the development of novel antimicrobial agents, innovative s

πŸ”— TL;DR: New paper, new antibiotic combinations, new doctor πŸŽ“ For all the juicy details, check out the full study here: doi.org/10.1093/jaca... #OpenAccess #ScienceTwitter #MedicalResearch #InfectiousDiseases #OneHealth #Microbiology @bsacandjac.bsky.social

16.04.2025 21:49 πŸ‘ 2 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0

πŸ‘ This work doesn’t happen in a vacuum: thanks to my principal supervisor Julia Dorin, and all my friends and colleagues at the LUMC, both in the Infectious Diseases department and the Leiden PulmoScience Lab

16.04.2025 21:49 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

🀝 Together, this work adds to the growing evidence base for advancing SAAP-148, other HDPs, and halicin for antibacterial therapy against AMR strains, both in combination and sequential therapy #AntibioticAlternatives

16.04.2025 21:49 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

πŸ’‘ When assessing the combination of preventative SAAP-148 and post-infection halicin treatment in these cultures, I also found that SAAP-148 and halicin only acted synergistically in skin but not in lung tissue (still beneficial though!) #CombinationTherapy #SequentialTreatment

16.04.2025 21:49 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
Post image

πŸ”¬ I expanded on this: instead using SAAP-148 as a preventative against AMR bacteria, applied in both HSEs and lung tissue cultures (PBECs). SAAP-148's activity was limited in PBECs against AMR bacteria, while active in HSEs due to the peptide being retained in cells

16.04.2025 21:49 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

☝ However, our team showed that SAAP-148 was effective against AMR bacteria in the dish, and also when infecting skin cultures (HSEs). Also, combining SAAP-148 with halicin (a repurposed antibacterial) was synergistic against AMR bacteria. Read it: www.mdpi.com/2079-6382/11... #SynergisticTherapy

16.04.2025 21:49 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0

πŸ” Few studies specifically investigate synergy between host defence peptides (HDPs), like SAAP-148, and conventional antibiotics. Even then, many don’t clarify this effects between agents, or assess them in more dimensional models. Reviewed here: www.mdpi.com/2079-6382/12...

16.04.2025 21:49 πŸ‘ 1 πŸ” 1 πŸ’¬ 1 πŸ“Œ 0
Post image

Happy to announce another published thesis chapter, now available in JAC-Antimicrobial Resistance! πŸŽ‰It features work from 3D cultures of skin and lung tissue as models of infection with #AMR bacteria, and therapy with the antimicrobial peptide SAAP-148 #AntimicrobialResistance @jac-amr.bsky.social

16.04.2025 21:49 πŸ‘ 6 πŸ” 2 πŸ’¬ 2 πŸ“Œ 0
SAAP-148 and halicin exhibit synergistic antimicrobial activity against antimicrobial-resistant bacteria in skin but not airway epithelial culture models The escalating global threat of antimicrobial resistance (AMR) necessitates the development of novel antimicrobial agents, innovative strategies, and representative infection models to combat AMR bacterial infections. Host defence peptides (HDPs) and their derivatives have been proposed as complements to conventional antibiotics due to their antibacterial activity and modulation of the immune response.ObjectivesThis study investigated the novel use of the HDP-derived synthetic antibacterial and anti-biofilm peptide (SAAP)-148 as a pretreatment in epithelial tissue models to prevent colonization by AMR bacteria. The combined activities of SAAP-148 pretreatment with post-infection halicin to treat infections were also explored.MethodsEmploying cultured human skin equivalents (HSEs) and primary bronchial epithelial cells (PBECs) as models of tissue infection, we examined the prophylactic and therapeutic effects of SAAP-148, both singularly and in combination with the repurposed antibiotic halicin, against AMR bacteria. We additionally interrogated the response of HSE and PBEC cultures to SAAP-148 treatment via confocal microscopy and quantitative PCR of native HDPs and inflammatory cytokine genes.ResultsOur findings demonstrated that pretreatment with SAAP-148 significantly reduces colonization of HSEs and PBECs by AMR Staphylococcus aureus and Pseudomonas aeruginosa. Confocal microscopy revealed differential uptake and localization of SAAP-148 in these tissues, correlating with its distinct activity in these tissues. SAAP-148 exposure temporarily increased expression of the HDPs cathelicidin (CAMP) and Ξ²-defensin 1 (DEFB1), and the cytokine IL-8 (CXCL8), which did not correlate with the transient antibacterial activity observed. Sequential treatment with SAAP-148 prior to infection with AMR S. aureus and post-infection halicin treatment demonstrated synergistic activity in HSEs, whereas this combined activity was indifferent in PBEC cultures.ConclusionsThese results support SAAP-148 as a candidate for pre-infection prophylaxis and synergistic antibiotic therapy with halicin in skin, broadening the potential of both agents to address AMR bacterial infection.

🦠 AMR poses a global threat. SAAP-148 reduced colonization of AMR bacteria in skin models. It boosted HDPs & IL-8. Synergistic effects with halicin were seen in skin, not in bronchial cells.

#idsky

11.04.2025 18:30 πŸ‘ 1 πŸ” 1 πŸ’¬ 0 πŸ“Œ 0