Margherita Zamboni

First paper from the lab is now online
@natneuro.nature.com !
We mapped injury induced enhancers in the mouse CNS and decoded their sequence architecture. Little 🧵 rdcu.be/eSQi1

We show that we can use this for precise targeting of reactive states, laying the groundwork for the next generation of specialized gene therapies!

We mapped thousands of injury-responsive enhancers in the mouse spinal cord.
By combining #multiomics with #DeepLearning and in-vivo validation, we reveal a regulatory code that glial cells use to respond to injury.

Thrilled to share our new publication on the regulatory code of injury responsive enhancers in the CNS!

www.nature.com/articles/s41...

@ellorens.bsky.social
@ki.se
@natneuro.nature.com

The regulatory code of injury-responsive enhancers enables precision cell-state targeting in the CNS - Nature Neuroscience Zamboni et al. reveal how enhancers encode cell-type-specific responses to CNS injury. By combining multiomic profiling, deep learning and in vivo screening, they uncover injury-responsive enhancer lo...

AMAZING PAPER ALERT!
www.nature.com/articles/s41...

congratulations to @margheritazamboni.bsky.social, @ellorens.bsky.social, and the rest of the team.
This one is important and opens up lots of opportunityes.