Antimicrobial Resistance, Omics & Microbiota (AROM) @ NTU

Lots of microbiology-related activities organised by @arom-ntu.bsky.social members at the Festival of Science and Curiosity in Nottingham.

Congratulations to former MRes students Mia Horton and Yashwani Malik on their new publication with @davidnegus.bsky.social, characterizing novel phages infecting Serratia spp.

academic.oup.com/jambio/advan...

#microsky

@mohamedeladawy.bsky.social @bugsinyourguts.bsky.social

A new preprint from my group, representing the PhD work of Rachael Duodu. Thanks to @bugsinyourguts.bsky.social for transcriptomics analysis!

Congratulations to Rachael Duodu on the first preprint from her PhD work, under the supervision of @jackcleo.bsky.social!

📢 We offer a fully funded 4-year #PhD position to work on tick #microbiota 🦠 dynamics using #genomics 🧬 at @irec-csic-uclm.bsky.social, supervised by @sdiazsanchez.bsky.social. For requisites and contact info, please check 👇

www.irec.es/noticias/pro...

This new review by Anne L McCartney and Lesley Hoyles examines the often overlooked role of Klebsiella bioactives in host-microbiota dynamics.

🔗 Access the full article here: doi.org/10.1530/MAH-24-0011

On our way to @mgeworkshop.bsky.social for @lotox.bsky.social to present later. Looking forward to some amazing talks! @arom-ntu.bsky.social #mgeworkshop

I am Honoured to have received the 2nd Prize at NTU's ⭐️ STAR (Science & Tech Annual Research) Conference!
Special thanks to my supervisors @conmeehan.bsky.social @blackpassiflora.bsky.social and collaborators @danwhiley.bsky.social @Kate Cox for the incredible support.
@arom-ntu.bsky.social

Host interactions of bioactive molecules produced by Klebsiella spp Abstract Klebsiella spp. are early colonisers and commensals of human skin, oral, nasal, throat and gut microbiotas, but are also opportunistic pathogens. Much of our information on these bacteria is ...

Great to see the typeset version of this invited review out.

Covers pretty much everything we know about metabolites/peptides produced by Klebsiella spp. and how they interact with the host. #microsky #microbiomesky @microbiotaandhost.bsky.social

doi.org/10.1530/MAH-...

Formation of the β-sheet at the extracellular opening of the intimin β-barrel domain is necessary for stability and efficient passenger secretion Attaching and effacing pathogens, such as enteropathogenic and enterohaemorrhagic E. coli, rely on an adhesin, intimin, for attachment to enterocytes and downstream effects leading to actin pedestal f...

New preprint out from Jack C. Leo and colleagues! #microsky

Pitfalls of bacterial pan-genome analysis approaches: a case study of M. tuberculosis and two less clonal bacterial species Abstract . Pan-genome analysis is a fundamental tool for studying bacterial genome evolution; however, the variety of methods used to define and measure th

Congratulations to @conmeehan.bsky.social and colleagues on the publication of their new manuscript. #microsky

🚨New publication🚨
We show that K. Pneumoniae bacteriophages can be incorporated into alginate to create an antibiofilm matrix effective against clinical K. pneumoniae strains
academic.oup.com/jambio/artic...

First from the @arom-ntu.bsky.social group is @jodywinter.bsky.social who was awarded the 2024 Microbiology in Society Award. Jody is talking about education outreach and research as an invited talk.

Genomic and phenotypic characterization of staphylococci isolated from the skin of non-human primates The growth of wildlife tourism coupled with continued deforestation has resulted in increased contact between non-human primates (NHPs) and humans. Such events may promote the transmission of potentia...

Congratulations to Caitlin Wildsmith on the second paper from her PhD with @davidnegus.bsky.social! #microsky

Genetic and phenotypic analysis of the virulence plasmid of a non-Shigatoxigenic enteroaggregative Escherichia coli O104:H4 outbreak strain Enteroaggregative Escherichia coli O104:H4 is best known for causing a worldwide outbreak in 2011 due to the acquisition of a Shiga-like toxin alongside traditional enteroaggregative virulence traits;...

Congratulations to PhD students Rachel and Lottie, and MRes student Martyna on their publication with @mcvickermicro.bsky.social! #microsky

www.microbiologyresearch.org/content/jour...

Genetic and phenotypic analysis of the virulence plasmid of a non-Shigatoxigenic enteroaggregative Escherichia coli O104:H4 outbreak strain Enteroaggregative Escherichia coli O104:H4 is best known for causing a worldwide outbreak in 2011 due to the acquisition of a Shiga-like toxin alongside traditional enteroaggregative virulence traits;...

Incredibly happy to see this paper come out! And first research paper for @lotox.bsky.social! Thanks also to all the collabs at @arom-ntu.bsky.social

www.microbiologyresearch.org/content/jour...

Congratulations to @conmeehan.bsky.social and colleagues on their new publication!

Menadione reduces the expression of virulence- and colonization-associated genes in Helicobacter pylori Novel treatment options are needed for the gastric pathogen Helicobacter pylori due to its increasing antibiotic resistance. The vitamin K analogue menadione has been extensively studied due to intere...

New paper from @jodywinter.bsky.social's team on how menadione affects transcriptional responses of Helicobacter pylori. Well done to PhD students Stephen and Rebecca! #microsky #Helicobacter

www.microbiologyresearch.org/content/jour...

We're running our introductory/launch event for LEAP tonight, unfortunately I can't attend as I'm full of a cold (not great look to start a super spreader event). Though LEAP we hope to bring in more public participation into our research, to find out more and keep up to date follow our BlueSky...

Deadline to apply for this PhD is 14 February.

Deadline to apply for this PhD is 14 February.

Deadline to apply for this PhD is 14 February.

Four novel nontuberculous mycobacteria species: Mycobacterium wendilense sp. nov., Mycobacterium burgundiense sp. nov., Mycobacterium kokjensenii sp. nov. and Mycobacterium holstebronense sp. nov. rev... Four novel nontuberculous mycobacteria were discovered from a historical strain collection at the International Reference Laboratory of Mycobacteriology at Statens Serum Institut in Copenhagen, Denmar...

New year, new publication! From @conmeehan.bsky.social and colleagues @tlillebaek.bsky.social ek.bsky.social and @micronorman.bsky.social describing four new species of Mycobacterium.

Surface-Functionalised Copper Oxide Nanoparticles: A Pathway to Multidrug-Resistant Pathogen Control in Medical Devices Copper oxide nanoparticles (CuONPs) offer promising antimicrobial properties against a range of pathogens, addressing the urgent issue of antibiotic resistance. This study details the synthesis of glu...

3. Surface-functionalised copper oxide nanoparticles: a pathway to multidrug-resistant pathogen control in medical devices - Dr James Hall, Dr Adam Varney, Dr Samantha McLean

Sage Journals: Discover world-class research Subscription and open access journals from Sage, the world's leading independent academic publisher.

2. Assessment of a light-curable hydrogel to be used for root canal obturation - Dr Sarah Kuehne

Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system | mBio Our work addresses two processes, the maintenance of plasmids and antibiotic tolerance; both contribute to the development of antimicrobial resistance in bacteria that cause human disease. Here, we fo...

Great end to the year for @arom-ntu.bsky.social, with three new publications out.

1. Shared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system - @mcvickermicro.bsky.social, Dr Jonathan Thomas

A blue and white poster with details of the launch event for the NTU LEAP initiative to listen, engage and analyse with the public for bioscience research.

At Nottingham Trent University (NTU), we’re tackling some of the biggest health challenges in society; dementia, cancer, diabetes, obesity, and infections. But we can’t do it alone.
Through our LEAP (Learn, Engage and Analyse with the Public) initiative, we want to hear your thoughts and (1/3)

Applied Microbiology International is here! Give them a follow @amiposts.bsky.social

#microsky #microbiomesky

Frameshift mutations in the mmpR5 gene can have a bedaquiline-susceptible phenotype by retaining a protein structure and function similar to wild-type Mycobacterium tuberculosis | Antimicrobial Agents... Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains the deadliest infectious disease and is particularly challenging to treat when it becomes drug-resistant. Bedaquiline (BDQ) is a recent...

Congratulations to @conmeehan.bsky.social and colleagues on their recent publication!

#microsky

New translational study from @bugsinyourguts.bsky.social and @drsimonmcarthur.bsky.social (at QMUL) showing how a microbiome-associated metabolite implicated in chronic kidney disease affects the blood–brain barrier. #microbiomesky