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Ye Lab

@liye-tsri

Ye lab at Scripps Research and HHMI. Neuroscience, Metabolism, and Chemical Biology. Opinions are my own and do not reflect those of my employer.

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19.02.2025
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Latest posts by Ye Lab @liye-tsri

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Single-cell and isoform-specific translational profiling of the mouse brain - Nature Post-transcriptional regulation of mRNA translation was explored using Ribo-STAMP and single-cell RNA sequencing to reveal cell-type-specific and isoform-specific translation patterns across hipp...

Chuffed to see our paper with @geneyeo.bsky.social finally published in @nature.com.
www.nature.com/articles/s41...
Very grateful to Fede, Susie, and Dave from my lab, and Sammi, Eric, and Pratibha from Gene's lab. What did we find? ⬇️ ⬇️ ⬇️

24.02.2026 18:03 👍 37 🔁 21 💬 1 📌 2

congrats!

12.02.2026 21:01 👍 2 🔁 0 💬 0 📌 0
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What if we could see 3D #biodistribution of cancer drugs at the cellular level... throughout an entire model animal? 🧐 A new paper from Li Ye's lab @scripps.edu, Zhengyuan Pang & Verina Leung et al. introduce a technique for doing just that. (1/3) 🧵

10.02.2026 16:05 👍 3 🔁 2 💬 1 📌 0

Thank you! @carolynbertozzi.bskyverified.social

22.12.2025 20:46 👍 0 🔁 0 💬 0 📌 0

Thrilled to share our latest work--combining CATCH with whole-body HYBRiD imaging, leveraging click chemistry to visualize and identify drug-targeted cells across organ systems. Led by a brilliant team: former PhD student Ben Pang and former undergrad Verina Leung.

22.12.2025 20:46 👍 15 🔁 4 💬 1 📌 0
quote from Chen Ran: “I feel very lucky to have the support of the Simons Foundation and to have access to this outstanding community.”

quote from Chen Ran: “I feel very lucky to have the support of the Simons Foundation and to have access to this outstanding community.”

Fellows-to-Faculty awardee Chen Ran maps the senses of internal organs. Receiving this award — which is currently open for apps — has been crucial in enabling his work: https://www.simonsfoundation.org/autism-and-neuroscience-innovators-awardees-share-their-research-at-the-annual-retreat/ #science

21.12.2025 19:17 👍 9 🔁 4 💬 0 📌 0

I’m sorry to say sd is not very sunny this week haha

13.11.2025 23:52 👍 1 🔁 0 💬 0 📌 0

RIP Jim Watson. You inspired many of us to pursue a life in research. I wish you had made it easier for us to celebrate your legacy.

07.11.2025 23:11 👍 64 🔁 7 💬 2 📌 0

Nothing beats the ceremony of dragging a grant from my pending folder to dead grant folder hahaha (sometimes it did give a big relief though)

09.11.2025 06:17 👍 2 🔁 1 💬 0 📌 0

Nothing beats the ceremony of dragging a grant from my pending folder to dead grant folder hahaha (sometimes it did give a big relief though)

09.11.2025 06:17 👍 2 🔁 1 💬 0 📌 0

Did aha approve the chips?

09.11.2025 06:14 👍 0 🔁 0 💬 0 📌 0

Deeply honored to receive this year's Tianqiao and Chrissy Chen Young Investigator Award from @sfn.org Grateful to all lab members and my mentors.

03.11.2025 20:55 👍 16 🔁 1 💬 2 📌 1

Come be my newest colleague! Scripps neuro is an energetic and supportive department, and uniquely benefits from proximity to our intimidatingly awesome chem and drug discovery programs. Happy to chat about my experiences here so far!

14.10.2025 18:33 👍 10 🔁 3 💬 0 📌 0
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Scripps Research-led team receives $14.2M NIH award to map the body’s “hidden sixth sense”

The NIH has awarded a $14.2M Director’s Transformative Research Award to a team led by Nobel Prize-winning neuroscientist @ardemp.bskyverified.social, Prof. @liye-tsri.bsky.social and Assoc. Prof. @xinjin.bsky.social to map interoception and build the first atlas of this hidden sixth sense.

10.10.2025 00:06 👍 124 🔁 25 💬 0 📌 0
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A parabrachial hub for need-state control of enduring pain - Nature Activity in a set of parabranchial neurons in the mouse brain is increased during chronic pain, predicts coping behaviour, and can be modulated by circuits activated by survival threats.

Finally out: our recent work with Nick Betley is a view into how the brain reshapes its behavior in the face of competing survival needs- and also a potential angle on treatment targets for enduring pain.

A brief rundown...

www.nature.com/articles/s41...

09.10.2025 13:15 👍 128 🔁 41 💬 9 📌 1

Coming to #SfN2025 in San Diego? Come join our Neuroscience Symposium a day before on Nov 13! Hear from a fantastic speaker lineup and interact with vibrant audience in our community and beyond.

Free registration link: www.eventbrite.com/e/dorris-neu...

08.10.2025 14:56 👍 6 🔁 2 💬 0 📌 1

What a small world!!! We left the island the next morning.

02.07.2025 23:15 👍 1 🔁 0 💬 0 📌 0

We were likely both at this place last night!

02.07.2025 05:20 👍 1 🔁 0 💬 1 📌 0

Congrats to @xinjin.bsky.social @tinakim-neuro.bsky.social and many others!

20.06.2025 02:05 👍 11 🔁 3 💬 1 📌 0

Welcome back!

04.06.2025 14:57 👍 1 🔁 0 💬 0 📌 0
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The U.S. Lit a Beacon for Science. Under Trump, Scientists Fear It’s Dimming

Talked to @KateZernike at @nytimes about my journey and the current moment for scientists in the U.S.

“Ardem Patapoutian’s story is not just the American dream, it is the dream of American science.”

Read the article here. No subscription required:

www.nytimes.com/2025/06/03/u...

03.06.2025 10:57 👍 229 🔁 94 💬 7 📌 7
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Congrats to Assist. Prof. Chen Ran (@chenran.bsky.social), one of just 15 selected as a 2025 Searle Scholar! 🌟

His work on how visceral signals are encoded in the brain was recognized for its potential to elucidate disease mechanisms & inform new therapeutics. More: ow.ly/HtLM50VN8sN

06.05.2025 23:00 👍 45 🔁 6 💬 6 📌 2
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SEARLE SCHOLARS PROGRAM NAMES 15 SCIENTISTS AS SEARLE SCHOLARS FOR 2025 Members of the new class of Searle Scholars pursue ground-breaking research in chemistry and the biomedical sciences. Each receives an award of $300,000 in flexible funding to support his, her, or …

Congratulations to @chenran.bsky.social on being named a Searle Scholar!

searlescholars.org/2025/04/14/s...

19.04.2025 23:56 👍 24 🔁 2 💬 2 📌 0
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Interoceptive processing in the nucleus of the solitary tract The interoceptive nervous system continuously monitors the status of visceral organs to synthesize internal perceptions and regulate behavioral and ph…

Lots of recent papers discuss the nucleus of the solitary tract in interoception. In this review, we take a sensory processing perspective on how interoceptive signals are encoded in the NTS:
www.sciencedirect.com/science/arti...

16.04.2025 04:02 👍 55 🔁 19 💬 0 📌 3

Great collaboration with @liye-tsri.bsky.social @dlipomi.bsky.social, and Jonathan Long labs and led by Yu Wang and Yunxiao Zhang 2/2

06.03.2025 19:12 👍 4 🔁 1 💬 0 📌 0