Pagès lab's Avatar

Pagès lab

@pageslab

DNA damage and genome instability group Cancer Research Center of Marseille. #DNAdamage, #TranslesionSynthesis, #HomologousRecombination, in bacteria & yeast

532
Followers 191
Following 9
Posts 04.10.2023
Joined
Posts Following

Latest posts by Pagès lab @pageslab

Post image

Exciting opportunity: we are hiring a postdoctoral fellow for a fully funded 2-year position!

14.11.2025 16:03 👍 4 🔁 7 💬 0 📌 0
Post image

Amazing view from the 24th floor of the Sorbonne tower at the 7th German-French DNA Repair Meeting! Excited to give my talk tomorrow!

05.11.2025 20:58 👍 5 🔁 1 💬 0 📌 0
The RecBC complex protects single-stranded DNA gaps during lesion bypass Following encounter with an unrepaired DNA lesion, replication is halted and can restart downstream of the lesion leading to the formation of a single-stranded DNA (ssDNA) gap. To complete replication...

open access version here: hal.science/hal-05250217

12.09.2025 07:26 👍 4 🔁 1 💬 0 📌 0
PNAS Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

New paper out! We show that RecBC remodels single-stranded DNA gaps to protect them from ExoI (sbcB) 3′-5′ exonuclease degradation during replication of damaged DNA.

doi.org/10.1073/pnas...

12.09.2025 07:26 👍 4 🔁 3 💬 1 📌 0
Post image

#RésultatScientifique 🔎 Découvrez la dernière publication de Vincent Pagès et de ses collaborateurs !

🤝 @cnrs-dr12.bsky.social @insermpacacorse.bsky.social @univ-amu.fr @paoli-calmettes.bsky.social @pageslab.bsky.social @crcm.bsky.social

👉 @narjournal.bsky.social
buff.ly/rVeGV9B

11.04.2025 15:04 👍 4 🔁 4 💬 0 📌 0

Thanks Annabel!

25.03.2025 05:53 👍 0 🔁 0 💬 0 📌 0

Our key findings:
-DNA polymerase η swiftly bypasses UV-induced lesions at the replication fork.
-Post-replicative gaps allow Translesion Synthesis (TLS) to compete with Damage Avoidance (DA), reducing mutagenicity.
-Gap extension by Exo1 nuclease favors DA and reduces TLS

24.03.2025 10:42 👍 3 🔁 0 💬 0 📌 0
Post image

Our latest article, in collaboration with Helle Ulrich, explores how the timing of lesion bypass and gap processing impacts genome stability.
doi.org/10.1093/nar/...

24.03.2025 10:42 👍 12 🔁 6 💬 4 📌 0
Post image

How does Pol IV overcome strong replication blocks in E. coli? Our latest study with @joeloparo.bsky.social uncovers a bipartite clamp interaction that helps Pol IV compete with Pol III, enabling efficient TLS at stalled forks and reducing mutagenesis.
https://buff.ly/3Xbgjxd

25.02.2025 10:17 👍 3 🔁 1 💬 0 📌 0
Post image

Recruiting a postdoc to work on our yeast project

17.12.2024 12:41 👍 3 🔁 1 💬 0 📌 0